Political scientists know surprisingly little about the political behavior of inventors, or those who produce new technologies. I therefore merged US patent and campaign contribution (DIME) data to reveal the donation behavior of 30,603 American inventors from 1980 through 2014. Analysis of the data produces three major findings. First, the Democratic Party has made significant inroads among American inventors, but these gains increasingly come from only a few regions and flow to a relatively small number of candidates. Second, deeper geographic trends explain most of the change in aggregate donation patterns. Third, inventors do not strategically donate to candidates outside their own district and, since 2006, inventors increasingly contribute to relatively centrist employer PACs with weak ties to the Democratic Party. These findings suggest that the interaction between market-oriented policy and American electoral institutions may inhibit the formation of broad cross-regional coalitions to support the knowledge economy.