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Glucocorticoids influence the development of gastric proteases in the neonatal pig

Published online by Cambridge University Press:  27 February 2018

P. T. Sangild  and
B. Foltmann
P. T. Sangild
Affiliation:
Department of Clinical Studies, Reproduction, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Denmark
B. Foltmann
Affiliation:
Department of Clinical Studies, Reproduction, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Denmark
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Extract

Adrenal glucocorticoids are known to stimulate the development of digestive enzymes in the sucking rat. In the pig, Cortisol concentrations in plasma reach peak levels at birth. We studied the effect of neonatal Cortisol levels on the development of two proteases, chymosin (rennin, EC 3.4.23.4) and pepsin A (EC 3.4.23.1) in the stomach of the pig.

Material and methods Three vaginal-delivered (VD) pigs (114 to 115 days gestation) were killed at birth. The remaining 40 newborn pigs were removed by caesarean section (SC) at 111 to 112 days gestation (i.e. 2 to 4 days before term). After birth these pigs were injected intramuscularly with either saline, metyrapone (an inhibitor of adrenal 11-deoxyhydrolase activity and Cortisol synthesis, 10 mg/kg per day) or ACTH (adrenocorticotropic hormone, 100μ/kg per day).

Type
Abstracts of posters
Information
BSAP Occasional Publication , Volume 15 , 1992 , pp. 185
Copyright
Copyright © British Society of Animal Production 1992

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