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A comparison of two intrauterine antibiotic treatments for endometritis in dairy cows by means of survival analysis

Published online by Cambridge University Press:  27 February 2018

S.H. Loeffler  and
A.C. de Zeeuw
S.H. Loeffler
Affiliation:
Animal Health Service, P.O. Box 9, 7400 AA Deventer, Holland
A.C. de Zeeuw
Affiliation:
Veterinary Practice Crimpenerwaert, Bergambacht, Holland
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Abstract

A prospective cohort study was designed to compare the effects of two different intrauterine antibiotic treatments for endometritis on fertility in a multi-farm trial during a 4 year-period. Product A contained 1.5 million I.E. of Procaine Penicilline-G and 500 mg of Neomycine sulfate in 20 ml of an oil in water suspension with a gas-driven applicator (Ubrocelan®, Boehringer-Ingelheim, Germany) and product B (positive control) contained 2g of Oxytetracycline and 500.000 I.E. Colistine in a 20 ml oil in water suspension (Colicycline® , A. U. V., Cuyk, The Netherlands). Diagnosis was by field veterinarians during routine monthly visits. Pyometra, vaginitis, toxic endometritis and post-insemination uterine treatments were excluded from the study. Only cases of non-toxic endometritis prior to first insemination in the period from 1- 150 days after calving were included. Cows were allocated to treatment group based on ear tag number (even/uneven) at the time of diagnosis by the veterinarian. Cows received only a single treatment. Cases were coded as censored at 150 days if not yet inseminated and at 180 days if not yet pregnant. A total of 623 cases of endometritis in first or later parity cows on 13 farms were used in the analysis. The distribution of treatments among farms was unequal ( chi-square = 0.167) , but no farm had more than 70% of one treatment and farm was included as a correction factorin all models. A larger number of controls than cases also had no effect on study outcome. The effect oftreament on the interval (days) from from treatment to conception or censoring was analyzed with a Cox proportional hazards model. Other variables included in the models were season, parity, herd and time of treatment (late/early) with respect to calving. There was no effect of treatment on the number of days to breeding or days open. Early/late ( cutoff = 40 days) endometritis was a significant factor for the interval from treatment to first insemination and conception rate to first breeding. Early/late metritis, however, was not a factor for the interval from treatment to pregnancy. This study suggests that there is an equal treatment efficacy for intrauterine therapy of endometritis between the two products tested. The authors discuss the growing trend away from intrauterine treatments and the suitability of survival analysis techniques for multi-farm field studies of this type.

Type
Posters
Information
BSAP Occasional Publication , Volume 26 , Issue 2: Fertility in the High-Producing Dairy Cow , September 2001 , pp. 417 - 421
Copyright
Copyright © British Society of Animal Science 2001

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