Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-20T01:01:06.114Z Has data issue: false hasContentIssue false

Scientific methods used to measure the efficacy of alternative therapies in animals

Published online by Cambridge University Press:  27 February 2018

A. D. Ellis
Affiliation:
Nottingham Trent University, School of Animal, Rural and Environmental Science, Brackenhurst, Southwell, Nottinghamshire NG25 0QF, UK
L. Hopegood
Affiliation:
Nottingham Trent University, School of Animal, Rural and Environmental Science, Brackenhurst, Southwell, Nottinghamshire NG25 0QF, UK
K. Hunter
Affiliation:
Nottingham Trent University, School of Animal, Rural and Environmental Science, Brackenhurst, Southwell, Nottinghamshire NG25 0QF, UK
Get access

Abstract

The aim of this report was to evaluate the methods used to test the efficacy of complementary and alternative veterinary medicine. A general review of available literature in this area was carried out and experimental design of 26 reported trials was analysed in detail. Quantitative evidence must form the basis of medicinal treatments, whether they fall under the traditional western medicine genre or whether they are seen as complementary or alternative therapies. Results from the quantitative characterisation of publications showed that within the ‘animal’ sector, the majority of work published is nonexperimental. Medline PubMed, for the years 1975 to 2005 returned a total of 400 review papers incorporating work from the human sector in alternative animal therapy in comparison to only 75 papers on experimental work. Of the 26 alternative veterinary medicine papers reviewed in detail 19 trials used a control group to assess the efficacy of the therapy tested. The experimental designs applied in clinical trials within this area are acceptable, using high levels of control and quantitative measurements. Improvements could be made through increased use of blind and double blind designs. Although there is lack of scientific evidence for alternative therapies, the application of these is continuously growing. This imbalance should be acknowledged and rectified.

Type
Research Article
Copyright
Copyright © British Society of Animal Production 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andersson, S. and Lundeberg, T. (1995) Acupuncture — from empiricism to science: Functional background to acupuncture effects in pain and disease. Medical Hypotheses, Volume 45, Issue 3, September 1995, Pages 271281 CrossRefGoogle ScholarPubMed
Bell, I. R., Baldwin, C. M., Schwartz, G. E. and Russek, L. G. S. (1998) Integrating belief systems and therapies in medicine: application of the eight world hypothesis to classical homeopathy, Integrative Medicine 1, 3, 95105,CrossRefGoogle Scholar
Bolt, D.M., Burba, D.J., Hubert, J.D., Strain, G.M., Hosgood, G.L., Henk, W.G. and Cho, D–Y. (2004) Determination of functional and morphologic changes in palmar digital nerves after nonfocused extracorporeal shock wave treatment in horses. AJVR, 65:12, 17141718.CrossRefGoogle ScholarPubMed
Bonnet, B. (1998) Evidence–based Medicine: Critical evaluation of new and existing therapies, In: Schoen, A. M. and Wynn, S. G. (1998) Complementary and Alternative Veterinary Medicine, Mosby, Inc.Google Scholar
Crowe, O.M., Dyson, S.J., Wright, I.M., Schramme, M.C. and Smith, R.K.W. (2004) Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse. EVJ, 36:4, 313316.Google Scholar
Da Costa Gomez, T.M., Radtke, C.L., Kalscheur, V.L., Swain, C.A., Scollay, M.C., Edwards, R.B., Santschi, E.M., Marketl, M.D. and Muir, P. (2004) Effect of focused and radial extracorporeal shock wave therapy on equine bone microdamage, Veterinary Surgery, 33, 4955.Google Scholar
de Moffarts, B., Kirschvink, N., Art, T., Pincemail, J. and Lekeux, P. (2005) Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses, The Veterinary Journal, Volume 169, 1, 6574 Google Scholar
Deaton, CM, Marlin, DJ, Roberts, CA, Smith, N, Harris, PA, Kelly, FJ, Schroter, RC. (2002) Antioxidant supplementation and pulmonary function at rest and exercise, Equine Vet J Suppl. (34):5865.Google Scholar
Elbers, A. R. W. and Schukke, Y. H. (1995) Papers and Articles: Critical features of veterinary field trials, The Veterinary Record, February 25, 1995CrossRefGoogle Scholar
Elliott, M. (2001) Cushing's Disease: a new approach to therapy in equine and canine patients, BritishHomeopathic Journal (2001) 90, 33±36 Google ScholarPubMed
Epp, T. S., McDonough, P., Padilla, D. J., Cox, J. H., Poole, D. C. and Erickson, H. H. (2005) The effect of a herbal supplementation on the severity of exercise–induced pulmonary haemorrhage, Eqine and Comparative Exercise Physiology 2 (); 1725 CrossRefGoogle Scholar
Ernst, E. (1999) Common misconceptions about alternative medicine. In: Ramey, D. (ed.) 1999 Consumer's guide to alternative therapies in the horse. Howell Book House, New York Google Scholar
Girao, V.C., Nunes–Pinheiro, D.C., Morais, S.M., Sequeira, J.L., Gioso, M.A. (2003) A clinical trial of the effect of a mouth–rinse prepared with Lippia sidoides Cham essential oil in dogs with mild gingival disease, Prev Vet Med. 30; 59 (1-2), 95102.Google Scholar
Gregory, M. A. and Mars, M. (2005) Compressed air massage causses capillary dilation in untraumatised skeletal muscle: a morphomteric and ultrastructural study, Physiotherapy, in pressGoogle Scholar
Hermann, J. R.. Honeyman, M. S Zimmerman, J. J. Thacker, B. J. Holden, P. J. and Chang, C. C. (2003) Effect of dietary Echinacea purpurea on viremia and performance in porcine reproductive and respiratory syndrome virus–infected nursery pigs, J. Anim Sci. 2003 81: 21392144.Google Scholar
Hielm–Bjorkman, A., Raekallio, M., Kuusela, E., Saarto, E., Markkola, A., Tulamo, R.M. (2001) Double–blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia, Vet Rec. 2001 Oct 13;149(15):452-6.Google Scholar
Holmes, M. A., Cockcroft, P. D., Booth, C. E. and Heath, M. F. (2005) Controlled clinical trial of the effect of a homeopathic nosode on the somatic cell counts in the milk of clinically normal diary cows, The Veterinary Record, April 30, 2005CrossRefGoogle Scholar
Huisheng, X. Ott, E.A. and Colahan, P. (2001) Influence of Acupuncture on experimental lameness in horses; AAEP PROCEEDINGS / Vol. 47 / 2001Google Scholar
Jarvis, W. (1999) Scientific versus unscientific thinking, In: Ramey, D. (ed.) (1999) Consumer's guide to alternative therapies in the horse, Howell Book House, New York Google Scholar
Kirschvink, N, Fievez, L, Bougnet, V, Art, T, Degand, G, Smith, N, Marlin, D, Roberts, C, Harris, P, Lekeux, P. Effect of nutritional antioxidant supplementation on systemic and pulmonary antioxidant status, airway inflammation and lung function in heaves–affected horses.Equine Vet J. 2002 Nov;34(7):705-12.Google ScholarPubMed
Klide, A.M., Martin, B.B. Jr. (1989) Methods of stimulating acupuncture points for treatment of chronic back pain in horses. J Am Vet Med Assoc, 15; 95 (10), 1375-9.Google Scholar
Kronfeld, D. S. (2005a) Strong evidence and the systematic review, Journal of Equine Veterinary Science, 24, 4, 231232 Google Scholar
Kronfeld, D. S. (2005b) Blind trials and better business, Journal of Equine Veterinary Science, 25, 4, 173174 Google Scholar
Martinson, B. C., Anderson, M. S. and de Vries, R. (2005) Scientists behaving badly, Nature, 435, 737738 Google Scholar
McBride, S. D., Hemmings, A. and Robinson, K. (2004) A preliminary study on the effect of massage to reduce stress in the horse, Journal of Veterinary Science, 24, 2, 7681 Google Scholar
McClure, S.R., VanSickle, D., Evans, R., Reinertson, E.L. and Moran, L. (2004) The effects of extracorporeal shock–wave therapy on the ultrasonographic and histologic appearance of collagenase–induced equine forelimb suspensory ligament desmitis. Ultrasound in Med. & Biol., 30, 461467.CrossRefGoogle ScholarPubMed
Medline–PubMed (2005) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi,accessed 10 August 2005, National Center for Biomedical InformationGoogle Scholar
Merritt, A. M., Xie, H., Lester, G. D., Burrow, J. A., Lorenzo–Figueras, M., Mahfoud, Z. (2002) Evaluation of a method to experimentally induce colic in horses and the effects of acupuncture applied at the Guanyuan–shu (similar to BL-21) acupoint, Am J Vet Res. 63(7):1006-11. Related Articles, LinksCrossRefGoogle ScholarPubMed
O’Neill, W., McKee, S., Clarke, A. F. (2002) Immunological and haematinic consequences of feeding a standardised Echinacea (Echinacea angustifolia) extract to healthy horses.Equine Vet J. 2002 May;34 (3):222-7.Google ScholarPubMed
Pauwels, F.E.T., McClure, S.R., Amin, V., Van Sickle, D. and Evans, R.B. (2004) Effects of extracorporeal shock wave therapy and radial pressure wave therapy on elasticity and microstructure of equine cortical bone. AJVR, 65:2, 207212.Google Scholar
Pullin, J. G., Collier, MA, Das, P., Smith, R. L., DeBault, L. E., Johnson, L. L., Walls, R. C. (1996) Effects of holmium: YAG laser energy on cartilage metabolism, healing, and biochemical properties of lesional and perilesional tissue in a weight-bearing model, Arthroscopy, 12():1525.Google Scholar
Ramey, D. W. and Rollin, B. E. (2003) Complementary and alternative veterinary medicine considered, Blackwell Publishing Ltd, Oxford, UKGoogle Scholar
Reichling, J, Schmokel, H, Fitzi, J, Bucher, S, Saller, R. (2004) Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweiz Arch Tierheilkd. Feb;146(2):71-9.Google Scholar
Science Direct (2005) http://www.sciencedirect.com, accessed 5 August 2005, Elsevier PublishersGoogle Scholar
Sellnow, L. (2005) Therapeutic Options, The Horse, August 2005 Google Scholar
Sumano, H., Bermudez, E., Obregon, K. (2000) Treatment of wobbler syndrome in dogs with electroacupuncture. Dtsch Tierarztl Wochenschrift 107(6):231-5.Google Scholar
Van den Hoven, R., Zappe, H., Zitterl–Eglseer, K., Jugl, M., Franz, C. (2003) Study of the effect of Bronchipret on the lung function of five Austrian saddle horses suffering recurrent airway obstruction (heaves), Vet Record 3;152(18):555-7Google Scholar
Varshney, J. P. and Naresh, R. (2004) Evaluation of a homeopathic complex in the clinical management of udder diseases of riverine buffaloes, Homeopathy 93, 1720 Google Scholar
Vaughn, L. (1999) How to evaluate evidence that things work, In: Ramey, D. (ed.) (1999) Consumer's guide to alternative therapies in the horse, Howell Book House, New York Google Scholar
Walach, H., Sherr, J., Schneider, R., Shabi, R., Bond, A. and Rieberer (2004) Homeopathic proving symptoms: result of a local, non–local or placebo process? A blinded, placebo–controlled pilot study, Homeopathy 93, 179185 Google Scholar
Weatherley–Jones, E., Thompson, E.A., Thomas, K.J. (2004) The placebocontrolled trial as a test of complementary and alternative medicine: observations from research experience of individualised homeopathic treatment, Homeopathy, 93, 186189 Google Scholar
Wilson, D.V., Lankenau, C., Berney, C.E., Peroni, D.L., Mullineaux, D.R. and Robinson, N.E. (2004) The effects of a single acupuncture treatment in horses with severe recurrent airway obstruction. EVJ, 36:6, 289494.Google Scholar