Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-05T21:43:26.644Z Has data issue: false hasContentIssue false
  • English
  • Français

3.2 The Role of Dose-Response Trials in Predicting Trace Element Deficiency Disorders

Published online by Cambridge University Press:  27 February 2018

M. Phillippo
M. Phillippo*
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen, AB2 9SB
Get access

Extract

The symptoms of trace element deficiency arise from the combined effects of the different lesions provoked within the animal body. Since a variety of different lesions have been described, many of which affect inter-related systems, it is not surprising that diverse symptoms may arise even from the one trace element deficiency; nor that similar symptoms may be caused by deficiencies of different trace elements. The major effects of trace element deficiencies on body functions have been outlined in Table 3.2.1 (from Underwood, 1980).

Type
3. Predicting Trace Element Disorders
Information
BSAP Occasional Publication , Volume 7: Trace Elements in Animal Production and Veterinary Practice , 1983 , pp. 51 - 59
Copyright
Copyright © British Society of Animal Production 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agricultural Research Council. 1980. The Nutrient Requirements of Ruminant Livestock. Comm. Agricultural Bureaux, Farnham Royal.Google Scholar
Arthur, J. R., Price, J. and Mills, C. F. 1979. Observations on the selenium status of cattle in the north-east of Scotland. Vet. Rec. 104: 340–341.CrossRefGoogle ScholarPubMed
Bingley, J. B. and Anderson, N. 1972. Clinically silent hypocuprosis and the effect of molybdenum loading on beef calves in Gippsland, Victoria. Aust. J. agric. Res. 23: 885–904.Google Scholar
Blackmore, L. W. and Mitchell, W. J. P. 1978. Lamb/hogget weight response trials to cobalt on the West Coast sand country of the North Island. N.Z.J. exp. Agric. 6: 179–182.Google Scholar
Blaxter, K. L. 1963. The effect of selenium administration on the growth and health of sheep on Scottish farms. Br. J. Nutr. 17: 105–115.CrossRefGoogle ScholarPubMed
Boyne, R. and Arthur, J. R. 1979. Alterations of neutrophil function in selenium deficient cattle. J. Comp. Path. 89: 151–158.Google Scholar
Boyne, R. and Arthur, J. R. 1981. Effects of selenium and copper deficiency on neutrophil function in cattle. J. Comp. Path. 91: 271–276.Google Scholar
Conrad, J. H. and Moxon, A. L. 1980. Selenium requirements for dairy cows. Ohio Report on Res. and Dev. 65: 8–9.Google Scholar
Cowie, R. S. and Dear, J. P. 1979. Pneumonia in single suckled calves. Vet. Rec. 98: 283.Google Scholar
Davies, H. L. and Chandrasekaran, M. 1980. Investigations of the effects of copper, cobalt and phosphorus on the growth of grazing Hereford cattle in coastal New South Wales. Proc. Aust. Soc. Anim. Prod. 13: 217–220.Google Scholar
Donaldson, L. E. 1960. Weight responses to copper therapy in cattle. Proc. Aust. Soc. Anim. Prod. 3: 167–169.Google Scholar
Engel, R. W., Hardison, W. A., Miller, R. F., Price, N. O. and Huber, J. T. 1964. Effect of copper intake on concentration in body tissue and on growth, reproduction and production in dairy cattle. J. Anim. Sci. 23: 1160–1163.CrossRefGoogle Scholar
Field, H. L. 1957a. Observations on copper deficiency in cattle in East Anglia. Part I. Vet. Rec. 69: 788–795.Google Scholar
Field, H. L. 1957b. Observations on copper deficiency in cattle in East Anglia. Part II. Vet. Rec. 69: 832–839.Google Scholar
Gartner, R. J. W., Young, T. G. and Pepper, P. M. 1968. Hepatic copper concentration of steers grazing pastures on developed wet heath land in south-eastern Queensland. Aust. J. exp. Agric. Anim. Husb. 8: 679–682.Google Scholar
Givens, D. I., Cross, P. J., Shaw, W. B. and Knight, P. E. 1979. Cobalt deficiency in growing lambs: a comparison of three forms of treatment. Vet. Rec. 104: 508–509.Google Scholar
Godwin, K. O., Kuchel, R. E. and Buckley, R. A. 1970. The effect of selenium on infertility in ewes grazing improved pastures. Aust. J. exp. Agric. Anim. Husb. 10: 672–678.Google Scholar
Gurnett, L. R. and Lawrence, N. G. 1978. The administration of copper to spring calving beef cows and their calves. Exp. Husb. 34: 97–102.Google Scholar
Gwazdauskas, F. C., Bibb, T. L., McGilliard, M. L. and Lineweaver, J. A. 1979. Effect of prepartum selenium-vitamin E injection on time for placenta to pass and on productive functions. J. Dairy Sci. 62: 978–981.Google Scholar
Haag, J. R. and Adams, F. W. 1958. Tissue copper relationships and copper status of cattle. Fed. Proc. 17: 477.Google Scholar
Hartley, W. J. 1963. Selenium and ewe fertility. Proc. N.Z. Soc. Anim. Prod. 23: 20.Google Scholar
Hidiroglou, M. and Jenkins, K. J. 1975. Effects of selenium and vitamin E and copper administrations on weight gains of beef cattle raised in a selenium deficient area. Canad. J. Anim. Sci. 55: 307–313.CrossRefGoogle Scholar
Hill, M. K., Walker, S. D. and Taylor, A. G. 1969. Effect of marginal deficiencies of copper and selenium on growth and productivity of sheep. N.Z. J. agric. Res. 12: 261–270.Google Scholar
Holm, A. M. and Payne, A. L. 1980. Effects of mineral supplementation on the performance of steers grazing birdwood grass (Cenchrusseliger) pastures in north Western Australia. Aust. J. exp. Agric. Anim. Husb. 20: 398–405.Google Scholar
Howard, D. A. 1970. The effects of cobalt and copper treatment on the weight gains and blood constituents of cattle in Kenya. Vet. Rec. 87: 771.CrossRefGoogle ScholarPubMed
Humphries, W. R., Young, B. W., Phillippo, M. and Bremner, I. 1981. The effect of iron and molybdenum on copper metabolism in cattle. Proc. Nutr. Soc. 40: 68A.Google Scholar
Jamieson, S. and Allcroft, R. 1950. Copper pine of calves. Br. J. Nutr. 4: 16–32.CrossRefGoogle ScholarPubMed
Jones, D. G. and Suttle, N. F. 1981. Some effects of copper deficiency on leucocyte function in sheep and cattle. Res. vet. Sci. 31: 151–156.CrossRefGoogle ScholarPubMed
Jorgensen, P. F. and Wegger, I. 1979. Glutathione peroxidase and health in swine. Acta Vet. Scand. 20: 610–612.CrossRefGoogle ScholarPubMed
Little, W., Vagg, J., Collis, K. A., Shaw, S. and Gleed, P. T. 1979. The effects of subcutaneous injections of sodium selenate on blood composition and milk yield in dairy cows. Res. vet. Set. 26: 193–197.Google Scholar
MacPherson, A. and Dixon, J. 1980. Effect of copper and cobalt treatment on finishing steers. Anim. Prod. 30: 373–381.Google Scholar
Macpherson, A., Moon, F. E. and Voss, R. C. 1973. Some effects of feeding young steers on a diet deficient in both cobalt and copper. Br. vet. J. 129: 414–425.CrossRefGoogle ScholarPubMed
MacPherson, A., Voss, R. C. and Dixon, J. 1979. The effect of copper treatment on the performance of hypocupraemic calves. Anim. Prod. 29: 91–99.Google Scholar
Mayland, H. F., Rosenau, R. C. and Florence, A. R. 1980. Grazing cows and calf responses to zinc supplementation. J. Anim. Sci. 51: 966–974.CrossRefGoogle ScholarPubMed
McDonald, I., Mills, C. F., Dalgarno, A. C. and Simpson, A. M. 1979. Rates of loss of hepatic copper during depletion of cattle. Proc. Nutr. Soc. 38: 59A.Google ScholarPubMed
McMurray, C. H. 1980. Copper deficiency in ruminants. In Biological Roles of Copper, CIBA Symposium Excerpts Medica Amsterdam, pp. 183–204.Google Scholar
Marston, H. R. 1970. The requirement of the sheep for cobalt or vitamin B12 . Br. J. Nutr. 24: 615–633.CrossRefGoogle ScholarPubMed
Mills, C. F., Dalgarno, A. C. and Wenham, G. 1976. Biochemical and pathological changes in tissues of Friesian cattle during the experimental induction of copper deficiency. Br. J. Nutr. 35: 309–331.CrossRefGoogle ScholarPubMed
Miltimore, J. E., Mason, J. L., Mcarthur, J. M. and Carson, R. B. 1964. Ruminant mineral nutrition. The effect of copper injections on weight gains and haemoglobin levels of cattle pastured on groundwater soils in British Columbia interior. Can. J. Comp. Med. vet. Sci. 28: 108–112.Google Scholar
Ministry of Agriculture, Fisheries and Food. 1982. Copper in ruminant animal nutrition. Report by ADAS/ARC/CSG Working Party.Google Scholar
Morgan, D. F., Clegg, A., Brooksbank, N. H. and MacRae, C. T. 1962. The effect of copper glycine injections on liveweight of suckling beef cows. Anim. Prod. 4: 303–307.Google Scholar
Newberne, P. M., Hunt, C. E. and Young, V. R. 1968. The role of diet and the reticulo-endothelial system in the response of rats to Salmonella typhimurium . Br. J. exp. Path. 49: 448–457.Google Scholar
Nielson, H. E., Danielson, V., Simesen, M. G., Gissel-Nielsen, G., Hjarde, W., Leth, T. and Basse, A. 1979. Selenium and vitamin E deficiency in pigs. 1. Influence on growth and reproduction. Acta Vet. Scand. 20: 276–288.CrossRefGoogle Scholar
Paynter, D. I., Anderson, J. W. and McDonald, J. W. 1979. Glutathione peroxidase and selenium in sheep. II. The relationship between glutathione peroxidase and selenium-responsive unthriftness in Merino lambs. Aust. J. agric. Res. 30: 703–709.Google Scholar
Peter, D. W. 1980. Selenium supplementation of grazing sheep. 3. Effects of supplementation of ewes before and/or after lambing on selenium status, blood enzyme activities and the growth of their lambs. Aust. J. agric. Res. 31: 1017–1027.Google Scholar
Phillippo, M., Humphries, W. R., Bremner, I. and Young, B. W. 1982a. Possible effect of molybdenum on fertility in the cow. Proc. Nutr. Soc. 41: 80A.Google Scholar
Phillippo, M., Humphries, W. R., Lawrence, C. B. and Price, J. 1982b. Investigation of the effect of copper status and therapy on the fertility in beef suckler herds. J. agric. Sci., Camb. 99: 359–364.Google Scholar
Pierce, C., Robinson, J. and Clawson, W. J. 1976. Calf response to repeated copper-selenium injections. J. Anim. Sci. 42: 1574 (Abstr.).Google Scholar
Piper, L. R., Bindon, B. M., Wilkins, J. F., Cox, R. J., Curtis, Y. M. and Cheers, M. A. 1980. The effect of selenium treatment on the fertility of Merino sheep. Proc. Aust. Soc. Anim. Prod. 13: 241–244.Google Scholar
Poole, D. B. R., Rogers, P. A. M. and Mccarthy, D. D. 1974. Induced copper deficiency in beef cattle: the effects of early and late supplementation on copper status and animal production throughout life. In Trace Element Metabolism (ed. Hoekstra, W. G., Suttie, J. W.. Ganther, H. E. and Mertz, W.), pp. 618–620. Univ. Park Press, Baltimore.Google Scholar
Price, J. and Humphries, W. R. 1980. Investigation of the effect of supplementary zinc on growth rate of beef cattle on farms in N. Scotland. J. agric. Sci., Camb. 95: 135–139.Google Scholar
Rogers, P. A. M. and Poole, D. B. R. 1977. The effects of Cu-EDTA injection on weight gain and copper status of calves and fattening cattle. In Trace Element Metabolism in Man and Animals (ed. Kirchgessner, M.), pp. 481–485.Google Scholar
Segerson, E. C. and Ganapathy, S. N. 1980. Fertilization of ova in selenium/vitamin E treated ewes maintained on two planes of nutrition. J. Anim. Sci. 51: 386–394.CrossRefGoogle ScholarPubMed
Segerson, E. C. and Johnson, B. H. 1980. Selenium and reproductive function in yearling Angus bulls. J. Anim. Sci. 51: 395–401.Google Scholar
Serfass, R. R. and Ganther, H. E. 1975. Defective microbicidal activity in glutathione peroxidase deficient neutrophils of selenium deficient rats. Nature 255: 640–641.CrossRefGoogle ScholarPubMed
Smith, B. L. 1980. Effect of high concentrations of zinc sulphate in drinking water of grazing yearling dairy cattle. N.Z. J. agric. Res. 23: 175–178.Google Scholar
Smith, R. J. and Thompson, J. M. 1978. Liveweight responses to copper injection in cattle in the Warrum-bungle region of N.S.W. Proc. Aust. Soc. Anim. Prod. 12: 122.Google Scholar
Stoszek, M. J. 1976. Copper deficiency in cattle in the Klamath Basin. Diss. Abstr. Int. 37B: 1501.Google Scholar
Suttle, N. F. 1980. Some preliminary observations on the absorbability of copper in fresh and conserved grass to sheep. Proc. Nutr. Soc. 38: 63A.Google Scholar
Suttle, N. F., Abrahams, P. W. and Thornton, I. 1982. The importance of soil type and dietary sulphur in the impairment of copper absorption in sheep which ingest soil. Proc. Nutr. Soc. 41: 83A.Google Scholar
Suttle, N. F., Field, A. C., Nicolson, T. B., Mathieson, A. O., Prescott, J. H. D., Scon, N. and Johnson, W. S. 1980. Some problems in assessing the psysiological and economic significance of hypocupraemia in beef suckler herds. Vet. Rec. 106: 302–304.CrossRefGoogle Scholar
Suttle, N. F. and McLauchlan, M. 1976. Predicting the effects of dietary molybdenum and sulphur on the availability of copper to ruminants. Proc. Nutr. Soc. 35: 22A.Google Scholar
Suttle, N. F., Thornton, I. and Alloway, B. 1975. An effect of soil ingestion on the utilization of dietary copper by sheep. J. agric. Sci., Camb. 84: 249–254.Google Scholar
Thornton, I., Kershaw, G. F. and Davies, M. K. 1972a. An investigation into copper deficiency in cattle in the Southern Pennines. I. Identification of suspect areas using geochemical reconnaissance followed by blood copper surveys. J. agric. Sci., Camb. 78: 157–163.CrossRefGoogle Scholar
Thornton, I., Kershaw, G. F. and Davies, M. K. 1972b. An investigation into copper deficiency in cattle in the Southern Pennines. II. Responses to copper supplementation. J. agric. Sci., Camb. 78: 165–171.CrossRefGoogle Scholar
Todd, J. R., Milne, A. A. and How, P. F. 1967. Hypocuprosis without clinical symptoms in single suckled cows. Vet. Rec. 82: 653–656.Google Scholar
Trinder, N., Woodhouse, C. D. and Renton, C. B. 1969. The effect of vitamin E and selenium on the incidence of retained placentae in dairy cows. Vet. Rec. 85: 550–555.Google Scholar
Underwood, E. J. 1980. Trace Elements in Human and Animal Nutrition. (4th edition). Academic Press, N.Y. and London.Google Scholar
Whitelaw, A., Armstrong, R. H., Evans, C. C. and Fawcett, A. R. 1979. A study of the effects of copper deficiency in Scottish Blackface lambs on improved hill pasture. Vet. Rec. 104: 455–460.CrossRefGoogle ScholarPubMed
Whitelaw, A. and Russel, A. J. F. 1979. Investigations into the prophylaxis of cobalt deficiency in sheep. Vet. Rec. 104: 8–11.CrossRefGoogle ScholarPubMed
Whitelaw, A., Russel, A. J. F., Armstrong, R. H., Evans, C. C., Fawcett, A. R. and White, I. R. 1981. Copper deficiency, a study of prophylaxis and the interaction with cobalt therapy in lambs on improved pastures. Anim. Prod. 33: 129–135.Google Scholar