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Zinc changes in blood and urine during cyclic pareteral nutrition: relationships with amino acid metabolism

Published online by Cambridge University Press:  06 August 2007

H. Faure ,
X. Leverve ,
J. Arnaud ,
C. Boujet  and
A. Favier
H. Faure
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
X. Leverve
Affiliation:
Unit of Parenteral Nutrition, University Hospital, 38043 Grenoble Cedex 09, France
J. Arnaud
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
C. Boujet
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
A. Favier
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
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Abstract

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Serum Zn, ultrafiltrable Zn and amino acids in serum and urine samples of twenty-seven patients receiving cyclic (12 h/24 h) parenteral nutrition were measured. These samples were collected in patients after a 12 h period of parenteral nutrition, and in the evening after 12 h without parenteral nutrition. The same determinations were performed in ten control subjects who followed the same sampling scheme. Total serum ultrafiltrable Zn showed no significant variations in the patients during parenteral nutrition, and was not significantly different in the two groups although the proportion of the Zn present in the ultrafiltrable fraction was elevated. Serum cystine levels were significantly higher (P = 0·05) in the patients than the control subjects, and cystine excretion was also higher in patients (P < 0·05) and increased after parenteral nutrition (56·0 (SE 6·5) v. 147·1 (SE 20·6) m/12 h; P < 0·001). Histidine levels did not vary significantly in serum after parenteral nutrition and were not different in the patients in comparison with the control subjects. Histidine excretion was not different in the two groups but increased significantly during parenteral nutrition (P < 0·05). Serum albumin was significantly depressed in the patients compared with the control subjects (45·3 (SE 1·5) v. 33·9 (SE 1·5) g/l; P < 0·001). These results suggest that cystine infusion and excretion relate to the changes occurring in serum Zn and in urinary Zn excretion.

Keywords

ZincParenteral nutritionAmino acids
Type
Zinc and amino acid interactions in parenteral nutrition
Information
British Journal of Nutrition , Volume 72 , Issue 5 , November 1994 , pp. 763 - 773
Copyright
Copyright © The Nutrition Society 1994

References

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