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Zinc absorption in adult humans: the effect of iron fortification

Published online by Cambridge University Press:  09 March 2007

Lena Davidson ,
Annette Almgren ,
Brittmarie Sandström  and
Richard F. Hurrell
Lena Davidson
Affiliation:
Nestec Ltd., Nestlé Research Centre, PO Box 44, CH-1000, Lausanne 26, Switzerland
Annette Almgren
Affiliation:
Department of Clinical Nutrition, Gothenburg University, Annedalsklinikerna, S-41345, Göteborg, Sweden
Brittmarie Sandström
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 25, DK-1958 Fredriksberg, Denmark
Richard F. Hurrell
Affiliation:
Nestec Ltd., Nestlé Research Centre, PO Box 44, CH-1000, Lausanne 26, Switzerland
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Abstract

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The effect of Fe fortification on the absorption of Zn was studied by radioisotopic labelling of single meals, followed by measurements of whole-body retention of 65Zn at 14 d after intake. Healthy adult volunteers participated in the study. Weaning cereal, wheat bread and infant formula, foods that are all frequently Fe-fortified, were evaluated in the study. The amounts of Fe added as FeSO4 were similar to the levels in commercial products in Europe and the USA, and were 200 or 500 mg Fe/kg (weaning cereal), 65 mg Fe/kg (white wheat flour) and 12 mg Fe/1 (infant formula). For comparison, Zn absorption was measured in the same subjects, from identical test meals containing no added Fe. No statistically significant differences were found when Zn absorption from the Fe-fortified test meals was compared with that from non-Fe-fortified test meals. Fractional Zn-absorption values from Fe-fortified v. non-fortified meals were 31·1 (sd 1·19) v. 30·7 (SD 7·0)% (weaning cereal; 200 mg Fe/kg), 37·7 (SD 16·6) v. 30·2 (SD 9·9)% (weaning cereal; 500 mg Fe/kg), 36·5 (SD 14·4) v. 38·2 (SD 18·1)% (bread; 65 mg Fe/kg flour) and 41·6 (SD 8·1) v. 38·9 (SD 14·5)% (infant formula; 12 mg Fe/1). The addition of Fe to foods at the currently used fortification levels was thus not associated with impaired absorption of Zn and the consumption of these Fe-fortified foods would not be expected to have a negative effect on Zn nutrition.

Keywords

ZincIronHumansRadioisotope
Type
Zinc absorption and iron fortification
Information
British Journal of Nutrition , Volume 74 , Issue 3 , September 1995 , pp. 417 - 425
Copyright
Copyright © The Nutrition Society 1995

References

Arvidsson, B., Cederblad, A, Björn-Rasmussen, E. & Sdndström, B. (1978). A radionuclide technique for studies of zinc absorption in man. International Journal of Nuclear Medicine and Biology 5, 104–109.CrossRefGoogle ScholarPubMed
Bloxam, D. L., Williams, N. R., Waskett, R. J., Pattison-Green, P. M., Morarji, Y. & Stewart, S. G. (1989). Maternal zinc during oral iron supplementation in pregnancy: a preliminary study. Clinical Science 76, 59–65.CrossRefGoogle ScholarPubMed
Bothwell, T. H., Charlton, R. W., Cook, J. D. & Finch, C. A. (1979). Iron Metabolism in Man. Oxford: Blackwell Scientific.Google Scholar
Bradley, C. K., Hillman, L., Sherman, A. R., Leedy, D. & Cordano, A. (1993). Evaluation of two iron-fortified ilk-based formulas during infancy. Pediatrics 91, 908–914.Google Scholar
Charlton, R. W. & Bothwell, T. H. (1983). Iron absorption. Annual Review of Medicine 34, 55–68.CrossRefGoogle ScholarPubMed
Cook, J. D. & Reusser, M. (1983). Iron fortification; an update. American Journal of Clinical Nutrition 38, 648–659.CrossRefGoogle ScholarPubMed
Craig, W. J., Balbach, L., Harris, S. & Vyhmeister, N. (1984). Plasma zinc and copper levels of infants fed different milk formulas. Journal of the American College of Nutrition 3, 183–186.Google Scholar
Crofton, R. W., Gvozdanovic, D., Gvozdanovic, S., Khin, C. C., Brunt, P. W., Mowat, N. A. G. & Aggett, P. J. (1989). Inorganic zinc and intestinal absorption of ferrous iron. American Journal of Clinical Nutrition 50, 141–144.CrossRefGoogle ScholarPubMed
Dawson, E. B., Albers, J. & McGanity, W. J. (1989). Serum zinc changes due to iron supplementation in teen-age pregnancy. American Journal of Clinical Nutrition 50, 848–852.CrossRefGoogle ScholarPubMed
DeMaeyer, E. & Adiels-Tegman, M. (1985). The prevalence of anaemia in the world. World Health Statistics Quarterly 38, 302–316.Google ScholarPubMed
Golden, B. E. & Golden, M. H. N. (1981). Plasma zinc, rate of weight gain, and the energy cost of tissue deposition in children recovering from severe malnutrition on a cow's milk or soya protein based diet. American Journal of Clinical Nutrition 34, 892–899.CrossRefGoogle ScholarPubMed
Haschke, F., Ziegler, E. E., Edwards, B. B. & Fomon, S. J. (1986). Effect of iron fortification of infant formula on trace mineral absorption. Journal of Pediatric Gastroenterology and Nutrition 5, 768–773.Google Scholar
Hurrell, R. F. (1992). Prospects for improving the iron fortification of foods. In Nutritional Anemias, pp. 193–208 [Fomon, S. J. and Zlotkin, S., editors]. New York: Raven Press, Ltd.Google Scholar
International Commission on Radiological Protection (1987). ICRP publication 53, Radiation dose to patients from radiopharmaceuticals. Annals of the ICRP 18 (1–4).Google Scholar
International Nutritional Anemia Consultative Group (1977). Guidelines for the Eradication of Iron Deficiency Anemia. New York: Nutrition Foundation.Google Scholar
Layrisse, M., Martinez-Torres, C., Mendez-Castellano, H., Taylor, P., Fossi, M., Lopez, de, Blanco, M., Landaeta-Jimez, M., Jaffe, W., Leets, I., Tropper, E., Garcia-Casal, M. N. & Ramirez, J. (1990). Relationship between iron bioavailability from diets and prevention of iron deficiency. Food Nutrition Bulletin 12, 301–309.Google Scholar
Lynch, S. R. & Hurrell, R. F. (1990). Iron in formulas and baby foods. In Iron Metabolism in Infants, pp. 109–126 [Lönnerdal, B. editor]. Boca Raton: CRC Press, Inc.Google Scholar
Newhouse, I. J., Clement, D. B. & Lai, C. (1993). Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Medicine and Science in Sports and Exercise 25, 562–571.Google Scholar
Rossander-Hultén, L., Brune, M., Sandstrom, B., Lönnerdal, B. & Hallberg, L. (1991). Competitive inhibition of iron absorption by manganese and zinc in humans. American Journal of Clinical Nutrition 54, 152–156.CrossRefGoogle ScholarPubMed
Salvioli, G. P., Faldella, G., Alessandroni, R., Lanari, M. & Benefenati, L. (1986). Plasma zinc concentrations in iron supplemented low birthweight infants. Archives of Disease in Childhood 61, 346–348.CrossRefGoogle ScholarPubMed
Sandström, B., Davidsson, L., Cederblad, A. & Lönnerdal, B. (1985). Oral iron, dietary ligands and zinc absorption. Journal of Nutrition 115, 411–414.CrossRefGoogle ScholarPubMed
Solomons, N. W. (1986). Competitive interaction of iron and zinc in the diet: consequences for human nutrition. Journal of Nutrition 116, 927–935.Google Scholar
Solomons, N. W. & Jacob, R. A. (1981). Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. American Journal of Clinical Nutrition 34, 475–482.CrossRefGoogle ScholarPubMed
Solomons, N. W., Pineda, O., Viteri, F. & Sandstead, H. H. (1983). Studies on the bioavailability of zinc in humans: mechanism of the intestinal interaction of nonheme iron and zinc. Journal of Nutrition 113, 337–349.Google Scholar
Valberg, L. S., Flanagan, P. R. & Chamberlain, M. J. (1984). Effects of iron, tin, and copper on zinc absorption in humans. American Journal of Clinical Nutrition 40, 536–541.CrossRefGoogle ScholarPubMed
Walravens, P. A. & Hambidge, K. M. (1976). Growth of infants fed a zinc-supplemented formula. American Journal of Clinical Nutrition 29, 1114–1121.CrossRefGoogle ScholarPubMed
Walravens, P. A., Hambidge, K. M. & Koepfer, D. M. (1989). Zinc supplementation in infants with a nutritional pattern of failure to thrive: a double-blind, controlled study. Pediatrics 83, 532–538.CrossRefGoogle ScholarPubMed
Walravens, P. A., Krebs, N. F. & Hambidge, K. M. (1983). Linear growth of low income preschool children receiving a zinc supplement. American Journal of Clinical Nutrition 38, 195–201.CrossRefGoogle ScholarPubMed
Yip, R., Reeves, J. D., Lönnerdal, B., Keen, C. L. & Dallman, P. R. (1985). Does iron supplementation compromise zinc nutrition in healthy infants? American Journal of Clinical Nutrition 42, 683–687.Google Scholar