Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T18:56:35.003Z Has data issue: false hasContentIssue false

Why are dietary nucleotides essential nutrients?

Published online by Cambridge University Press:  09 March 2007

George K. Grimble
Affiliation:
Addictive Behaviour CentreRoehampton Institute London Whitelands CollegeWest HillLondonSW15 3SN
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Guest Editorial
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

Adjei, A. A. & Yamamoto, S. (1995). A dietary nucleoside-nucleotide mixture inhibits endotoxin-induced bacterial translocation in mice fed protein-free diet. Journal of Nutrition 125, 4248.Google ScholarPubMed
Bower, R. H., Cerra, F. B., Bershadsky, B., Licari, J. J., Hoyt, D. B., Jensen, G. L., van Buren, C. T., Rothkopf, M. M., Daly, J. M. & Adelsberg, B. R. (1995). Early enteral administration of a formula (Impact®) supplemented with arginine, nucleotides, and fish-oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Critical Care Medicine 23, 436449.CrossRefGoogle ScholarPubMed
Brunser, O., Espinoza, J., Araya, M., Cruchet, S. & Gil, A. (1994). Effect of dietary nucleotide supplementation on diarrhoea1 disease in infants. Acta Paediutrica 83, 188191.CrossRefGoogle Scholar
Bueno, J., Torres, M., Almendros, A., Carmona, R., Nuñez, M. C., Rios, A. & Gil, A. (1994). Effect of dietary nucleotides on small intestinal repair after diarrhoea Histological and ultrastructural changes. Gut 35,926933.CrossRefGoogle ScholarPubMed
D'Mello, J. P. F. (1982). Utilization of dietary purines and pyrimidines by non-ruminant animals. Proceedings of the Nutrition Society 41, 301308.CrossRefGoogle ScholarPubMed
Daly, J. M., Lieberman, M. D., Goldfine, J., Shou, J., Weintraub, F., Rosato, E. F. & Lavin, P. (1992). Enteral nutrition with supplemental arginine, RNA and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery 112, 5667.Google ScholarPubMed
Giesecke, D. & Tiemeyer, W. (1982). Availability and metabolism of purines of single-cell proteins in monogastric animals. Proceedings of the Nutrition Society 41, 319327.CrossRefGoogle ScholarPubMed
Golden, M. H. N., Waterlow, J. C. & Picou, D. (1981). Metabolism in 15N nucleic acids in children. In Nitrogen Metabolism in Man, pp. 269273 [Waterlow, J. C. and Stephen, J.M.L., editors]. London: Applied Science Publishers.Google Scholar
Goody, H. E. & Ellem, K. A. O. (1975). Nutritional effects on precursor uptake and compartmentalization of intracellular pools in relation to RNA synthesis. Biochimica et Biophysica Acta 383, 3039.CrossRefGoogle ScholarPubMed
Grimble, G.K. (1993). Essential and conditionally-essential nutrients in clinical nutrition. Nutrition Research Reviews 6, 97119.CrossRefGoogle ScholarPubMed
Grimble, G. K. (1994). Dietary nucleotides and gut mucosal defence. Gut 35 (Suppl.), S46S51.CrossRefGoogle ScholarPubMed
Henderson, J. F., Lowe, J. K. & Barankiewicz, J. (1977). In Purine and Pyrimidine Metabolism. Ciba Foundation Symposium 48.Amsterdam:Elsevier.Google Scholar
Leleiko, N. S., Martin, B. A., Walsh, M., Kazlow, P., Rabinowitz, S. & Sterling, K. (1987). Tissue-specific gene expression results from a purine- and pyrimidine-free diet and 6-mercaptopurine in the rat small intestine and colon. Gastroenterology 93, 10141020.CrossRefGoogle ScholarPubMed
Leleiko, N. S., Bronstein, A. D., Baliga, B. S. & Munro, H. N. (1983). De novo purine nucleotide synthesis in the rat small and large intestine: effect of dietary protein and purines. Journal of Pediatric Gastroenterology and Nufrition 2, 313319.CrossRefGoogle ScholarPubMed
López-Navarro, A. T., Gil, A. & Sánchez-Pozo, A. (1995). Deprivation of dietary nucleotides results in a transient decrease in acid soluble nucleotides and RNA concentration in rat liver. Journal of Nutrition 125, 20902095.CrossRefGoogle Scholar
López-Navarro, A. T., Bueno, J. D., Gil, A. & Sánchez-Pozo, A. (1996). Morphological changes in hepatocytes of rats deprived of dietary nucleotides. British Journal of Nutrition 76, 579589.CrossRefGoogle ScholarPubMed
Ogoshi, S., Iwasa, M., Tonegarua, T. & Tamiya, T. (1985). Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70 % hepatectomy. Journal of Parenteral and Enteral Nutrition 9, 339342.CrossRefGoogle ScholarPubMed
Wiegers, U., Krarner, G., Klapproth, K. & Hilz, H. (1976). Separate pyrimidine-nucleotide pools for messenger-RNA and ribosomal-RNA synthesis in HeLa S3 cells. European Journal of Biochemistry 64, 535540.CrossRefGoogle ScholarPubMed
Zollner, N. (1982). Purine and pyrimidine metabolism. Proceedings of the Nutrition Society 41, 329342.CrossRefGoogle ScholarPubMed