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Vitamin B12 absorption in megaloblastic anaemia

Published online by Cambridge University Press:  24 July 2007

B. Senewiratne ,
J. Hettiarachchi  and
Kamalini Senewiratne
B. Senewiratne
Affiliation:
Clinical Research Unit, Department of Medicine, University of Sri Lanka, Peradeniya Campus, Sri Lanka
J. Hettiarachchi
Affiliation:
Clinical Research Unit, Department of Medicine, University of Sri Lanka, Peradeniya Campus, Sri Lanka
Kamalini Senewiratne
Affiliation:
Clinical Research Unit, Department of Medicine, University of Sri Lanka, Peradeniya Campus, Sri Lanka
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Abstract

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1. The response to cyanocobalamin and folic acid therapy was studied in forty-seven subjects with severe nutritional megaloblastic anaemia; twenty-five were vitamin B12 deficient and, of these, ten were also folic acid deficient.

2. In twenty-four of the subjects, absorption of orally administered cyanocobalamin was normal, and there was a haematological response to small doses of orally administered cyanocobalamin, indicating adequate absorption. In one subject there was impaired cyanocobalamin absorption although free gastric hydrochloric acid was present.

3. The findings indicate that the absorptive function of the small intestine was unimpaired, with one exception, although there was a possible defect in nucleoprotein synthesis associated with a lack of vitamin B12 and folic acid. Addisonian pernicious anaemia was not found in any of the subjects.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 32 , Issue 3 , November 1974 , pp. 491 - 501
Copyright
Copyright © The Nutrition Society 1974

References

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