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True fractional calcium absorption in Chinese children measured with stable isotopes (42Ca and 44Ca)

Published online by Cambridge University Press:  09 March 2007

Warren T.L. Lee ,
Sophie S.F. Leung ,
Susan J.Fairweather-Tait ,
Dora M.Y. Leung ,
Heidi S.Y. Tsang ,
John Eagles ,
Tom Fox ,
S.H. Wang ,
Y.C. Xu  and
W.P. Zeng
...Show all authors
Warren T.L. Lee
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Sophie S.F. Leung
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Susan J.Fairweather-Tait
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
Dora M.Y. Leung
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Heidi S.Y. Tsang
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
John Eagles
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
Tom Fox
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
S.H. Wang
Affiliation:
Department of Nutrition and Food Hygiene, Sun Yat Sen University of Medical Sciences, Guangzhou, China
Y.C. Xu
Affiliation:
Department of Nutrition and Food Hygiene, Sun Yat Sen University of Medical Sciences, Guangzhou, China
W.P. Zeng
Affiliation:
Jiangmen Epidemic Station, Jiangmen, Guandong Province, China
Joseph Lau
Affiliation:
Centre for Clinical Trials and Epidemiological Research, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
J.R.L. Masarei
Affiliation:
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
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Abstract

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True fractional Ca absorption (TFCA) was compared in children with different habitual Ca intakes using a double-label stable-isotope technique. Chinese children aged 7 years from Hongkong (n 22) and Jiangmen (n 12) participated in the study. An oral administration of 8 mg 44Ca in 100 g chocolate milk was given shortly after an intravenous injection of 0·75 mg 42Ca. Ca isotopic ratios were determined in urine samples collected 24 h later using thermal-ionization mass spectrometry. There was no significant difference in TFCA between Jiangmen and Hongkong children (P=0·16). TFCA of a lower-Ca-intake group (Ca > 500 mg/d, n 19) with mean Ca intake 359 mg/d was 63·1 (SD 10·7)%; and that of a higher-Ca-intake group (Ca > 500 mg/d, n 15) with mean Ca intake 862 mg/d was 54·8 (SD 7·3)%; the difference in TFCA was significant (P=0·016). Serum levels of 25-hydroxycholecalciferol of the children were adequate (33·7 (SD 7·7) ng/ml). The present study indicates that growing children accustomed to a low-Ca diet appear to be able to enhance their absorptive capacity. If it is assumed that dietary Ca absorption by Chinese children resembles their TFCA from a single meal of chocolate milk, then the recommended dietary allowance (RDA) for Ca for Chinese children would be lower than the US RDA (800 mg/d), which is based on an estimated 40% Ca absorption as reported for Caucasian children. A comparative absorption study is necessary to determine whether there is any difference in TFCA between Caucasian and Chinese children.

Keywords

CalciumChildhoodDouble-label stable-isotope technique
Type
Studies of mineral absorption and bioavaility
Information
British Journal of Nutrition , Volume 72 , Issue 6 , December 1994 , pp. 883 - 897
Copyright
Copyright © The Nutrition Society 1994

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