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True fractional calcium absorption in Chinese children measured with stable isotopes (42Ca and 44Ca)

Published online by Cambridge University Press:  09 March 2007

Warren T.L. Lee ,
Sophie S.F. Leung ,
Susan J.Fairweather-Tait ,
Dora M.Y. Leung ,
Heidi S.Y. Tsang ,
John Eagles ,
Tom Fox ,
S.H. Wang ,
Y.C. Xu  and
W.P. Zeng
...Show all authors
Warren T.L. Lee
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Sophie S.F. Leung
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Susan J.Fairweather-Tait
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
Dora M.Y. Leung
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
Heidi S.Y. Tsang
Affiliation:
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
John Eagles
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
Tom Fox
Affiliation:
AFRC Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA
S.H. Wang
Affiliation:
Department of Nutrition and Food Hygiene, Sun Yat Sen University of Medical Sciences, Guangzhou, China
Y.C. Xu
Affiliation:
Department of Nutrition and Food Hygiene, Sun Yat Sen University of Medical Sciences, Guangzhou, China
W.P. Zeng
Affiliation:
Jiangmen Epidemic Station, Jiangmen, Guandong Province, China
Joseph Lau
Affiliation:
Centre for Clinical Trials and Epidemiological Research, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
J.R.L. Masarei
Affiliation:
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hongkong, Shatin, Hongkong
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Abstract

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True fractional Ca absorption (TFCA) was compared in children with different habitual Ca intakes using a double-label stable-isotope technique. Chinese children aged 7 years from Hongkong (n 22) and Jiangmen (n 12) participated in the study. An oral administration of 8 mg 44Ca in 100 g chocolate milk was given shortly after an intravenous injection of 0·75 mg 42Ca. Ca isotopic ratios were determined in urine samples collected 24 h later using thermal-ionization mass spectrometry. There was no significant difference in TFCA between Jiangmen and Hongkong children (P=0·16). TFCA of a lower-Ca-intake group (Ca > 500 mg/d, n 19) with mean Ca intake 359 mg/d was 63·1 (SD 10·7)%; and that of a higher-Ca-intake group (Ca > 500 mg/d, n 15) with mean Ca intake 862 mg/d was 54·8 (SD 7·3)%; the difference in TFCA was significant (P=0·016). Serum levels of 25-hydroxycholecalciferol of the children were adequate (33·7 (SD 7·7) ng/ml). The present study indicates that growing children accustomed to a low-Ca diet appear to be able to enhance their absorptive capacity. If it is assumed that dietary Ca absorption by Chinese children resembles their TFCA from a single meal of chocolate milk, then the recommended dietary allowance (RDA) for Ca for Chinese children would be lower than the US RDA (800 mg/d), which is based on an estimated 40% Ca absorption as reported for Caucasian children. A comparative absorption study is necessary to determine whether there is any difference in TFCA between Caucasian and Chinese children.

Keywords

CalciumChildhoodDouble-label stable-isotope technique
Type
Studies of mineral absorption and bioavaility
Information
British Journal of Nutrition , Volume 72 , Issue 6 , December 1994 , pp. 883 - 897
Copyright
Copyright © The Nutrition Society 1994

References

RERERENCES

Abrams, S. A., Lipnick, R. N., Vieira, N. C., Stuff, J. E. & Yergey, A. L. (1993) Calcium absorption and metabolism in children with juvenile rheumatoid arthritis assessed using stable isotopes. Journal of Rheumatology 20, 1196–1200.Google ScholarPubMed
Anderson, J. J. B. (1992) The role of nutrition in the functioning of skeletal tissue. Nutrition Review 50, 388–394.CrossRefGoogle ScholarPubMed
Begum, A. & Pereira, S. M. (1969) Calcium balance studies on children accustomed to low Ca intakes. British Journal of Nutrition 23, 905–911.CrossRefGoogle Scholar
Bingham, S. A. (1987) The dietary assessment of individuals: methods, accuracy, new techniques and recommendations. Nutrition Abstracts and Reviews 57, 705–742.Google Scholar
Burke, B. S. (1947) The dietary history as a tool in research. Journal of the American Dietetic Association 23, 1041–1046.CrossRefGoogle Scholar
Chan, E. P. L., Lau, E., Shek, C. C., MacDonald, D., Woo, J., Leung, P. C. & Swaminathan, R. (1992) Agerelated changes in bone density, serum parathyroid hormone, calcium absorption and other indices of bone metabolism in Chinese women. Clinical Endocrinology 36, 375–381.CrossRefGoogle ScholarPubMed
Church, C. F. & Church, H. N. (1975) Food Values of Portions Commonly Used. Philadelphia: J. B. Lippincott Co.Google Scholar
DeGrazia, J. A., Ivanovich, P., Fellows, H. & Rich, C. (1965) A double label technique for measurement of intestinal absorption of calcium in man. Journal of Laboratory and Clinical Medicine 66, 822–829.Google Scholar
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: HM Stationery Office.Google Scholar
Department of Health (1972) Food Composition Table for Use in South East Asia. Bethesda, Md: Department of Health, Education and Welfare.Google Scholar
Eastell, R., Vieira, N. E., Yergey, A. L. & Riggs, L. (1989) One-day test using stable isotopes to measure true fractional calcium absorption. Journal of Bone and Mineral Research 4, 463–468.CrossRefGoogle ScholarPubMed
Fairweather-Tait, S. J., Johnson, A., Eagles, J., Ganatra, S., Kennedy, H. & Gurr, M. I. (1989) Studies on calcium absorption from milk using double-label stable isotope technique. British Journal of Nutrition 62, 379–388.CrossRefGoogle ScholarPubMed
Food and Agriculture Organization/World Health Organization Expert Group (1962) Calcium Requirements. FA0 Nutrition Meetings Report Series no. 230. Rome: FAO.Google Scholar
German Society of Nutrition (1991) Recommendations on Nutrient Intake, 5th revised ed. Frankfurt: German Society of Nutrition.Google Scholar
Grindulis, H., Scott, P. H. & Belton, N. R. (1986) Combined deficiency of iron and vitamin D in Asian toddlers. Archives of Disease in Childhood 61, 843–848.CrossRefGoogle ScholarPubMed
Heaney, R. P., Saville, P. D. & Recker, R. R. (1975) Calcium absorption as a function of calcium intake. Journal of Laboratory and Clinical Medicine 85, 881–887.Google ScholarPubMed
Hegsted, D. M., Moscoso, I. & Carlos Collazos, C. H. (1952) A study of the minimum calcium requirements of adult. Journal of Nutrition 48, 181–201.CrossRefGoogle Scholar
Heumann, K. G. (1988) Isotope dilution mass spectrometry. In Inorganic Mass Spectrometry, pp. 301–376 [Adams, F., Gijbels, R. and van Grieken, R., editors]. New York: J. Wiley & Sons.Google Scholar
Hillman, L. S., Tack, E., Covell, D. G., Vieira, N. E. & Yergey, A. L. (1988) Measurement of true calcium absorption in premature infants using intravenous 46Ca and oral 44Ca. Pediatric Research 23, 589–594.CrossRefGoogle ScholarPubMed
Ho, Z. C. (1988) Prevalence of nutritional problems in infants and preschool children in China. In Proceedings of the Second International Symposium on Maternal and Infant Nutrition, pp. E54–55 [Yeung, D. L. and Ho, Z. C., editors]. Guangzhou: Heinz Institute of Nutritional Sciences.Google Scholar
Institute of Health (1980) Food Composition Table. Chinese Academy of Medical Sciences. Beijing: Chinese People's Health Publishing Co.Google Scholar
Jain, M. G. (1989) Diet history: questionnaire and interview techniques used in some retrospective studies of cancer. Journal of the American Dietetic Association 89, 1647–1652.CrossRefGoogle ScholarPubMed
Lee, W. T. K., Leung, S. S. F., Lui, S. S. H. & Lau, J. (1993 a) Relationship between long-term calcium intake and bone mineral content of children aged from birth to 5 years. British Journal of Nutrition 70, 235–248.CrossRefGoogle ScholarPubMed
Lee, W. T. K., Leung, S. S. F., Ng, M. Y., Wang, S. F., Xu, Y. C., Zeng, W. P. & Lau, J. (1993 b) Bone mineral content of two populations of Chinese children with different calcium intakes. Bone and Mineral 23, 195–206.CrossRefGoogle ScholarPubMed
Leung, S. S. F. & Lui, S. S. H. (1990) Nutritive value of Hongkong Chinese weaning diet. Nutrition Research 10, 707–715.CrossRefGoogle Scholar
Leung, S. S. F., Lui, S. & Swaminathan, R. (1989) Vitamin D status of Hongkong Chinese infants. Acta Paediatrica Scandinavica 78, 303–306.CrossRefGoogle ScholarPubMed
Leung, S. S. F., Wu, M. Y., Yeung, W. M., Wong, C. K. & Pang, C. P. (1993) Prevalence of nutritional rickets in infants of Quangzhou: accuracy of diagnosing rickets basing on clinical features alone. Hong Kong Journal of Paediatrics 9, 229–232.Google Scholar
Marr, J. W. (1971) Individual dietary surveys: purposes and methods. World Review of Nutrition and Dietetics 13, 105–164.CrossRefGoogle ScholarPubMed
Matkovic, V. (1991) Calcium metabolism and calcium requirements during skeletal modelling and consolidation of bone mass. American Journal of Clinical Nutrition 54, 245S–260S.CrossRefGoogle ScholarPubMed
Matkovic, V. (1992) Calcium and peak bone mass. Journal of Internal Medicine 231, 151–160.CrossRefGoogle ScholarPubMed
Matkovic, V., Fontana, D., Tominac, C., Goel, P. & Chesnut, C. H. III. (1990) Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. American Journal of Clinical Nutrition 52, 878–888.CrossRefGoogle ScholarPubMed
Miller, J. Z., Smith, D. L., Flora, L., Slemenda, C. & Jiang, X. (1988) Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. American Journal of Clinical Nutrition 48, 1291–1294.CrossRefGoogle Scholar
Moore, L. J. (1984) Stable isotope measurements with thermal and resonance ionisation mass spectrometry. In Stable Isotopes in Nutrition, pp. 1–26 [Turnlund, J.R. and Johnson, P. E., editors]. Washington, DC: American Chemical Society.Google Scholar
Mueller, T. R. & Walker, R. L. (1987) Isotopic determination of calcium by thermal ionisation using a VG 354 mass spectrometer. Proceedings of the 35th ASMS Conference on Mass Spectrometry and Allied Topics, p. 993. Denver, CO: ASMS.Google Scholar
National Research Council (1989) Food and Nutrition Board: Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy Press.Google Scholar
Nicholls, L. & Nimalasuriya, A. (1939) Adaptation to a low calcium intake in reference to the calcium requirements of a tropical population. Journal of Nutrition 18, 563–577.CrossRefGoogle Scholar
Nordin, B. E. C.(editor) (1976) Plasma calcium and plasma magnesium homeostasis. In Calcium, Phosphate and Magnesium Metabolism, pp. 186–216. Edinburgh: Churchill Livingstone.Google Scholar
Norman, A. W. (1990) Intestinal calcium absorption: a vitamin D-hormone-mediated adaptive response. American Journal of Clinical Nutrition 51, 290–300.CrossRefGoogle ScholarPubMed
Norman, D. A., Fordtran, J. S., Brinkley, J., Zerwekh, J. E., Nicar, M. J., Strowig, S. M. & Pak, C. Y. C. (1981) Jejunal and ileal adaptation to alterations in dietary calcium. Journal of Clinical Investigation 67, 1599–1603.CrossRefGoogle ScholarPubMed
Paul, A. A. & Southgate, D. A. T. (1978) McCance and Widdowson's the Composition of Foods, 4th revised ed. London: HM Stationery Office.Google Scholar
Recker, R. R., Bammi, A., Barger-Lux, M. & Heaney, R. P. (1988) Calcium absorbability from milk products, an imitation milk, and calcium carbonate. American Journal of Clinical Nutrition 47, 93–95.CrossRefGoogle ScholarPubMed
Roth, P. & Werner, E. (1985) Interrelationship of radiocalcium absorption tests and their clinical reference. Mineral and Electrolyte Metabolism 11, 351–357.Google Scholar
Smith, K. T., Heaney, R. P., Flora, L. & Hinders, S. M. (1987) Calcium absorption from calcium citrate-malate. Calcified Tissues International 41, 351–352.CrossRefGoogle Scholar
Tackett, J. R. & Ellefson, R. E. (1987) Isotopic analysis of calcium. Proceedings of the 35th ASMS Conference on Mass Spectrometry and Allied Topics, Abstr. Denver, CO: ASMS.Google Scholar
Tung, T. C., Huang, P. C. & Li, H. C. (1961) Composition of foods used in Taiwan. Journal of the Formosan Medical Association 60, 973–1005.Google ScholarPubMed
Watt, B. K. & Merrill, H. L. (1983) Composition of Foods. Agriculture Handbook no. 8. Washington, DC: Department of Agriculture.Google Scholar
Woo, J., Swaminathan, R., Pang, C. P., Mak, Y. T. & MacDonald, D. (1990) A comparison of biochemical indices of bone turnover in elderly institutionalised and free-living subjects. Bone and Mineral 8, 31–38.CrossRefGoogle ScholarPubMed
Yergey, A. L., Vieira, N. E. & Covell, D. G. (1987) Direct measurement of dietary functional absorption using calcium isotopic tracers. Biochemical and Environmental Mass Spectrometry 14, 603–607.CrossRefGoogle ScholarPubMed