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Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight

Published online by Cambridge University Press:  09 March 2007

P. A. Flecknell ,
R. Wootton  and
Muriel John
P. A. Flecknell
Affiliation:
Division of Comparative Medicine andClinical Research Centre, Watford Road, Harrow, HAI 3UJ
R. Wootton
Affiliation:
Division of Radioisotopes, Clinical Research Centre, Watford Road, Harrow, HAI 3UJ
Muriel John
Affiliation:
Division of Comparative Medicine andClinical Research Centre, Watford Road, Harrow, HAI 3UJ
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Abstract

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1. Neonatal hypoglycaemia is a relatively common clinical problem in children but ethical constraints limit the investigations that may be made in the newborn.

2. As a preliminary step to assess the suitability of the piglet as a model for glucose metabolism in man, whole-body glucose turnover and glucose pool size were measured using [2-3H]glucose in forty piglets from ten litters.

3. Glucose pool size was linearly related to brain weight. However, multiple regression showed that the most useful predictors of pool size were body-weight and resting plasma glucose concentration.

4. Glucose turnover was related to both brain weight and body-weight alone, but multiple regression showed that better predictors of turnover were liver weight, spleen weight and pancreas weight.

5. Similarities between our own results in piglets and those obtained in human neonates by Bier et al. (1977) extend not only to glucose turnover, but also to its relationship with body-and brain weight. These findings suggest that the piglet may be a useful model for the study of glucose metabolism in babies.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 2 , September 1980 , pp. 193 - 203
Copyright
Copyright © The Nutrition Society 1980

References

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