Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-17T16:16:33.858Z Has data issue: false hasContentIssue false
  • English
  • Français

α-Tocopherol supplements and high-density-lipoprotein–cholesterol levels

Published online by Cambridge University Press:  09 March 2007

John H. Kalbfleisch ,
Joseph J. Barboriak ,
Barbara A. Else ,
C. Vincent Hughes  and
Felix E. Tristani
John H. Kalbfleisch
Affiliation:
Research Service1, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Departments of Anesthesiology3, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Joseph J. Barboriak
Affiliation:
Research Service1, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Pharmacology4, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Barbara A. Else
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA
C. Vincent Hughes
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Medicine5, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Felix E. Tristani
Affiliation:
Cardiopulmonary Rehabilitation Center2, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193, USA Medicine5, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. In a randomized, double-blind 6-month study, α-tocopherol (728 mg) or placebo were administered daily to seventy-eight volunteers (forty-nine men, twenty-nine women) to investigate the possible enhancing effect of vitamin E on plasma high-density-lipoprotein-cholesterol (HDL-C) levels. In addition, the available reported values from short-term (4–6 weeks) studies, as well as the 4-week results from the present study, were combined and analysed for factors which may modify the effect of α-tocopherol on HDL-C.

2. No consistent effect of α-tocopherol on plasma HDL-C levels was observed either in the combined 4-week values or in the 6-month study. Further analysis of the combined short-term values and 6-month values indicated that, in subjects with low initial HDL-C levels, treatment with α-tocopherol or placebo did not produce significantly different HDL-C changes.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 1 , January 1986 , pp. 71 - 77
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Barboriak, J. J., El Ghatit, A. Z., shetty, K. R. & kalbfleisch, J. H. (1982). American Journal of Clinical Pathology 77, 371–372.Google Scholar
Block, W. D., Jarret, J. K. & Levine, J. B. (1965). In Automation in Analytical chemistry, pp. 345–347 [Skeggs, L. T. Jr, editor]. New york: Mediad. Inc.Google Scholar
Chapkin, R. S., Haberstrah, B., Liu, T. & Holub, B. J. (1983). American Journal of Clinical Nutrition 38, 253–256.CrossRefGoogle Scholar
Criqui, M. H., Frankville, D. D., Barrett-connor, E., Klauber, M. R., Holdbrook, M. J. & Turner, J. D. (1983). American Journal of Epidemiology 118, 52–59.CrossRefGoogle Scholar
Ehnholm, C., Huttunen, J. K., Kostiainen, E., Lukka, M. & Aho, K. (1982). Clinical Chemistry Acta 121, 321–325.CrossRefGoogle Scholar
Hatam, L. J. & Kayden, H. J. (1981). American Journal of Clinical Pathology 76, 122–124.CrossRefGoogle Scholar
Herman, W. J. (1981 a). American Journal of Clinical Pathology 76, 124–126.CrossRefGoogle Scholar
Herman, W. J. (1981 b). American Journal of Clinical Pathology 76, 844–845.CrossRefGoogle Scholar
Herman, W. J., Ward, K. & Faucett, J. (1979). American Journal of Clinical Pathology 72, 848–852.Google Scholar
Howard, D. R., Rundell, C. A. & Batsakis, J. G. (1982). American Journal of Clinical Pathology 77, 86–89.CrossRefGoogle Scholar
Ingelfinger, J. A., Mosteller, F., Thibodeau, L. A. & Ware, J. H. (1983). Biostatistics in Clinical Medicine. New york: Macmillan Publishing Company Inc.Google Scholar
Kesaniemi, Y. A. & Grundy, S. M. (1982). American Journal of Clinical Nutrition 36, 224–228.CrossRefGoogle Scholar
Kessler, G. & Lederen, H. (1965). In Automation in Analytical Chemistry, pp. 341–344 [Skeggs, L. T. Jr, editor]. New york: Mediad, Inc.Google Scholar
National institutes of Health (1979). DHEW Publication no. 75–628. 78, 1661.Google Scholar
Schwartz, P. L. & Rutherford, I. M. (1981). American Journal of Clinical Pathology 76, 843–844.CrossRefGoogle Scholar
Serfontein, W. J., Ubbink, J. B. & de Villiers, L. S. (1983). American Journal of Clinical Pathology 79, 604–606.CrossRefGoogle Scholar
Snedecor, W. G. & Cochran, G. W. (1969). Statistical Methods, 6th ed. Ames, Iowa: Iowa State University Press.Google Scholar
Stampfer, M. J., Willett, W., Castelli, W. P., Taylor, J. O., Fine, J. & Hennekens, C. H. (1983). American Journal of Clinical Pathology 79, 714–716.CrossRefGoogle Scholar
Sundaram, G. S., London, R., Manimekala, S., Nair, P. P. & Goldstein, P. (1981). Lipids 16, 223–227.CrossRefGoogle Scholar