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Tissue S-adenosylmethionine levels in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced neuropathy

Published online by Cambridge University Press:  09 March 2007

J. van der Westhuyzen  and
J. Metz
J. van der Westhuyzen
Affiliation:
MRC Brain Metabolism Research Group, School of Pathology, South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, South Africa
J. Metz
Affiliation:
MRC Brain Metabolism Research Group, School of Pathology, South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, South Africa
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Abstract

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1. The effect of cobalamin inactivation by the anaesthetic gas nitrous oxide on the concentration of S-adenosylmethionine (Ado Met) in brain and liver of fruit bats (Rousettus aegyptiacus) was examined.

2. Test animals exposed to N2O–oxygen (50:50, v/v) developed ataxia and paralysis leading to death after an average of 9·8 weeks (n 6). Animals receiving pteroylmonoglutamic acid supplements in the diet became ataxic earlier (mean 8·8 weeks) while those receiving methionine supplements survived for significantly longer periods (12·5 weeks, P < 0·01).

3. Plasma cobalamin levels indicated severe depletion of cobalamin stores in N2O-exposed animals.

4. The mean concentration of Ado Met in the brain of N2O-treated bats was nearly 50% higher than that of untreated controls. Ado Met levels in treated bats receiving pteroylmonoglutamic acid or methionine supplements were respectively 18 and 25% higher than in controls. In contrast, the concentration of Ado Met in the liver of all the N2O-treated groups was slightly lower than in controls.

5. These results suggest that the N2O-induced neuropathy in the fruit bat is not related to a depletion of Ado Met in the nervous system.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 50 , Issue 2 , September 1983 , pp. 325 - 330
Copyright
Copyright © The Nutrition Society 1983

References

REFERENCES

Baldessarini, R. J. (1966). Biochemical Pharmacology 15, 741–748.CrossRefGoogle Scholar
Banks, R. G. S., Henderson, R. J. & Pratt, J. M. (1968). Journal of the Chemical Society (A), 2886–2889.CrossRefGoogle Scholar
Case, G. L. & Benevenga, N. J. (1977). Journal of Nutrition 107, 1665–1676.CrossRefGoogle Scholar
Chanarin, I. (1981). Lancet ii, 755.CrossRefGoogle Scholar
Chanarin, I., Deacon, R., Lumb, M. & Perry, J. (1980). Lancet ii, 505–508.CrossRefGoogle Scholar
Deacon, R., Chanarin, I., Perry, J. & Lumb, M. (1980 a). Biochemical and Biophysical Research Communications 93, 516–520.CrossRefGoogle Scholar
Deacon, R., Lumb, M., Perry, J., Chanarin, I., Minty, B., Halsey, M. J. & Nunn, J. F. (1980 b). European Journal of Biochemistry 104, 419–422.CrossRefGoogle Scholar
Dinn, J. J., McCann, S., Wilson, P., Reed, B., Weir, D. & Scott, J. (1978). Lancet ii, 1154.CrossRefGoogle Scholar
Eloranta, T. O., Kajander, E. O. & Raina, A. M. (1976). Biochemical Journal 160, 287–294.CrossRefGoogle Scholar
Finkelstein, J. D., Harris, B. J., Martin, J. J. & Kyle, W. E. (1982). Biochemical and Biophysical Research Communications 108, 344–348.CrossRefGoogle Scholar
Green, R., Newmark, P. A., Musso, A. M. & Mollin, D. L. (1974). British Journal of Haematology 27, 507–526.CrossRefGoogle Scholar
Green, R., van Tonder, S. V., Oettle, G. J., Cole, G. & Metz, J. (1975). Nature 254, 148–150.CrossRefGoogle Scholar
Schlenk, F. (1965). In Transmethylation and Methionine Biosynthesis, pp. 48–65 [Shapiro, S. K. and Schlenk, F., editors]. Chicago: University of Chicago Press.Google Scholar
Scott, J. M., Dinn, J., Wilson, P. & Weir, D. G. (1981). Lancet ii, 334–337.CrossRefGoogle Scholar
Scott, J. M. & Weir, D. G. (1981). Lancet ii, 337–340.CrossRefGoogle Scholar
Steinberg, S. E., Campbell, C. & Hillman, R. S. (1981). Biochemical and Biophysical Research Communications 98, 983–989.CrossRefGoogle Scholar
van der Westhuyzen, J., Fernandes-Costa, F. & Metz, J. (1982). Life Sciences 31, 2001–2010.CrossRefGoogle Scholar
Vidal, A. J. & Stokstad, E. L. R. (1974). Biochimica et Biophysica Acta 362, 245–257.CrossRefGoogle Scholar