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Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment

Published online by Cambridge University Press:  09 March 2007

Justin Van Der Westhuyzen ,
Richard E. Davis ,
Graham C. Icke  and
Jack Metz
Justin Van Der Westhuyzen
Affiliation:
Department of Haematology, School of Pathology, of the South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, Republic of South Africa
Richard E. Davis
Affiliation:
Department of Haematology, Royal Perth Hospital, Perth, Western Australia
Graham C. Icke
Affiliation:
Department of Haematology, Royal Perth Hospital, Perth, Western Australia
Jack Metz
Affiliation:
Department of Haematology, School of Pathology, of the South African Institute for Medical Research and the University of the Witwatersrand, PO Box 1038, Johannesburg 2000, Republic of South Africa
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Abstract

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1. Long-term exposure of the fruit bat Rousettus aegyptiacus to nitrous oxide, which inactivates methylco balamin, leads to neurological impairment and ataxia.

2. In N2, O-exposed animals, liver concentrations of total folates and methyl folates decreased to less than one fifth that of control animals. Pediococcus cerevisiue-active folates were also reduced.

3. In brain, there were no changes in total or methyl folates, but P.cerevisiae-active folates were lower in N2, O-exposed animals.

4. Supplementation with methionine retarded the development of neurological impairment and the fall in liver total and methyl folates, but not that in P. cerevisiae-active folates.

5. Supplementation with serine failed to retard the development of neurological impairment or fall in hepatic folates.

6. The present results suggest that the N2O-induced neurological impairment in the bat is not related to depletion of cerebral folates, but do not exclude changes in the subcellular distribution of folates.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 3 , November 1987 , pp. 485 - 491
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Banks, R. G. S., Henderson, R. J. & Pratt, J. M. (1968). Journal of the Chemical Society A, 2886–2889.CrossRefGoogle Scholar
Carl, G. F., Peterson, J. D., McClain, L. D. & Bridgers, W. F. (1980). Journal of Neurochemistry 34, 1442–1452.CrossRefGoogle Scholar
Chanarin, I., Deacon, R., Lumb, M., Muir, M. & Perry, J. (1985). Blood 66, 479–489.CrossRefGoogle Scholar
Davis, R. E., Nicol, D. J. & Kelly, A. (1970). Journal of Clinical Pathology 23, 47–53.Google Scholar
Deacon, R., Lumb, M., Perry, J., Chanarin, I., Minty, B., Halsey, M. J. & Nunn, J. (1980 a). European Journal of Biochemistry 104, 419–422.Google Scholar
Deacon, R., Perry, J., Lumb, M. & Chanarin, I. (1980 b). Biochemical and Biophysical Research Communications 97, 1324–1328.Google Scholar
Fehling, C., Jägerstad, M., Akesson, B., Axelsson, J. & Brun, A. (1978). British Journal of Nutrition 39, 501–513.Google Scholar
Frenkel, E. P. (1973). Journal of Clinical Investigation 52, 1237–1245.Google Scholar
Green, R., van Tonder, S. V., Oettle, G. J., Cole, G. & Metz, J. (1975). Nature 254, 148–150.CrossRefGoogle Scholar
Herbert, V. & Zalusky, R. (1961). Federation Proceedings 20, 453(Abstr).Google Scholar
Kelly, A. & Davis, R. E. (1965). Journal of Vitaminology 11, 68–72.CrossRefGoogle Scholar
Krumdieck, C. L., Tamura, T. & Eto, I. (1983). Vitamins and Hormones 40, 45–104.Google Scholar
Kutzbach, C. & Stokstad, E. L. R. (1967). Biochimica et Biophysica Acta 139, 217–220.Google Scholar
Lumb, M., Deacon, R., Perry, J., Chanarin, I., Minty, B., Halsey, M. J. & Nunn, J. F. (1980). Biochemical Journal 186, 933–936.CrossRefGoogle Scholar
Lumb, M., Perry, J., Deacon, R. & Chanarin, I. (1981 a). Scandanavian Journal of Haematology 26, 61–64.Google Scholar
Lumb, M., Perry, J., Deacon, R. & Chanarin, I. (1981 b). American Journal of Clinical Nutrition 34, 2412–2417.Google Scholar
Lumb, M., Perry, J., Deacon, R. & Chanarin, I. (1982). British Journal of Haematology 51, 235–242.Google Scholar
Lumb, M., Sharer, N., Deacon, R., Jennings, P., Purkiss, P., Perry, J. & Chanarin, I. (1983). Biochimica et Biophysica Acta 756, 354–359.CrossRefGoogle Scholar
McGing, P., Reed, B., Weir, D. G. & Scott, J. M. (1978). Biochemical and Biophysical Research Communications 82, 540–546.Google Scholar
Peifer, J. J. & Lewis, R. D. (1979). Journal of Nutrition 109, 2160–2172.CrossRefGoogle Scholar
Perry, J., Chanarin, I., Deacon, R. & Lumb, M. (1979 a). Biochemical and Biophysical Research Communications 91, 678–684.Google Scholar
Perry, J., Chanarin, I., Deacon, R. & Lumb, M. (1983). Journal of Clinical Investigation 74, 1183–1190.Google Scholar
Perry, J., Lumb, M., van der Westhuyzen, J., Fernandes-Costa, F., Metz, J. & Chanarin, I. (1979 b). Biochimica et Biophysica Acta 586, 632–636.Google Scholar
Perry, J., Lumb, M., van der westhuyzen, J., Fernandes-costa, F., Metz, J. & Chanarin, I. (1979 c). In Chemistry and Biology of Pteridines, pp. 315–320 [Kisliuk, J. L. and Brown, G. M., editors]. Amsterdam: Elsvier North Holland.Google Scholar
Scott, J. M., Dinn, J. J., Wilson, P. & Weir, D. G. (1981). Lancet ii, 334–337.Google Scholar
Spector, R. & Lorenzo, A. V. (1975). American Journal of Physiology 229, 777–782.Google Scholar
van der Westhuyzen, J., Cantrill, R. C., Fernandes-Costa, F. & Metz, J. (1983). Journal of Nutrition 113, 531–537.Google Scholar
van der Westhuyzen, J., Fernandes-Costa, F. & Metz, J. (1982 a). Life Sciences 31, 2001–2010.CrossRefGoogle Scholar
van der Westhuyzen, J., Fernandes-Costa, F., Metz, J., Kanazawa, S., Drivas, G. & Herbert, V. (1982 b). Proceedings of the Society for Experimental Biology and Medicine 171, 88–91.Google Scholar
van der Westhuyzen, J. & Metz, J. (1983). British Journal of Nutrition 50, 325–330.CrossRefGoogle Scholar
van der Westhuyzen, J. & Metz, J. (1984). Journal of Nutrition 114, 11O6–1111.CrossRefGoogle Scholar
van Tonder, S. V., Ruck, A., van der Westhuyzen, J., Fernandes-Costa, F. & Metz, J. (1986). British Journal of Nutrition 55, 187–192.Google Scholar
Yoshida, T. & Kikuchi, G. (1970). Archives of Biochemistry and Biophysics 139, 380–392.Google Scholar