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Thiamin nutrition and catalysis-induced instability of thiamin diphosphate

Published online by Cambridge University Press:  08 March 2007

Jennifer A. McCourt ,
Peter F. Nixon  and
Ronald G. Duggleby
Jennifer A. McCourt
Affiliation:
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
Peter F. Nixon
Affiliation:
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
Ronald G. Duggleby*
Affiliation:
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
*
*Corresponding author: Dr R. G. Duggleby, fax +617 3365 4699, email [email protected]
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Abstract

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Thiamin (vitamin B1) is required in animal diets because it is the precursor of the enzyme cofactor, thiamin diphosphate. Unlike other B vitamins, the dietary thiamin requirement is proportional to non-fat energy intake but there is no obvious biochemical reason for this relationship. In the present communication we show for two enzymes that the cofactor undergoes a slow destruction during catalysis, which may explain the interdependence of thiamin and energy intakes.

Keywords

Cofactor instabilityDietary requirementEnergy metabolismEnzyme cofactorThiamin diphosphateVitamin B1
Type
Short Communication
Information
British Journal of Nutrition , Volume 96 , Issue 4 , October 2006 , pp. 636 - 638
Copyright
Copyright © The Nutrition Society 2006

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