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Thiamin nutrition and catalysis-induced instability of thiamin diphosphate
Published online by Cambridge University Press: 08 March 2007
Abstract
Thiamin (vitamin B1) is required in animal diets because it is the precursor of the enzyme cofactor, thiamin diphosphate. Unlike other B vitamins, the dietary thiamin requirement is proportional to non-fat energy intake but there is no obvious biochemical reason for this relationship. In the present communication we show for two enzymes that the cofactor undergoes a slow destruction during catalysis, which may explain the interdependence of thiamin and energy intakes.
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- Copyright © The Nutrition Society 2006