Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-25T19:50:56.608Z Has data issue: false hasContentIssue false
  • English
  • Français

Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus)

Published online by Cambridge University Press:  09 March 2007

Hedva Miller ,
F. Fernandes-Costa  and
J. Metz
Hedva Miller
Affiliation:
Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of the Witwatersrand, Johannesburg, South Africa
F. Fernandes-Costa
Affiliation:
Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of the Witwatersrand, Johannesburg, South Africa
J. Metz
Affiliation:
Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of the Witwatersrand, Johannesburg, South Africa
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. DNA synthesis in the bone marrow and lymphocytes of the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus) has been studied via the deoxyuridine (dU) suppression test.

2. In contrast to vitamin B12 deficiency in man, the dU suppression test was not abnormal in the vitamin B12-deficient bat, and this correlates with the reported finding that the latter does not develop megaloblastic anaemia.

3. The protection of haemopeiesis from vitamin B12 deficiency in the bat is probably related to the presence in the bat of separate pools of methylfolate and tetrahydrofolate, which enables the bat to overcome the trapping of methylfolate attendant on vitamin B12 deficiency.

4. These results confirm the central role of the vitamin B12 and folate-dependent pathway of de novo synthesis of DNA in the pathogenesis of vitamin B12-deficient megaloblastic anaemia.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 44 , Issue 3 , November 1980 , pp. 229 - 235
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Das, K. C. & Herbert, V. (1978). Br. J. Haemat. 38, 219.Google Scholar
Das, K. C., Herbert, V., Colman, N. &Longo, D. L. (1978). Br. J. Haemat. 39, 357.CrossRefGoogle Scholar
Das, K. C. & Hoffbrand, A. V. (1970). Br. J. Haemat. 19, 459.Google Scholar
Ganeshaguru, K. & Hoffbrand, A. V. (1978). Br. J. Haemat. 40, 29.Google Scholar
Green, R., Myers, P. & Jacobson, D. (1979). 3rd Syrnp. on Vitamin B12 and Intrinsic Factor, Zurich 107. Abstr.Google Scholar
Green, R., Newmark, P. A., Musso, A. M. & Mollin, D. L. (1974). Br. J. Haemat. 27, 507.CrossRefGoogle Scholar
Green, R., Van Tonder, S., Oettle, G. J., Cole, G. & Metz, J. (1975). Nature, Lond. 254, 148.Google Scholar
Herbert, V., Tisman, G., Go, L. R. & Brenner, L. (1973). Er. J. Haemat. 24, 713.Google Scholar
Herbert, V. & Zalusky, R. (1962). J. clin. Invest. 41, 1263.Google Scholar
Killman, S. A. (1964). Acta mad. scund. 175, 483.CrossRefGoogle Scholar
Metz, J., Kelly, A., Swett, V. C., Waxman, S. & Herbert, V. (1968). Br. J. Haemat. 14, 575.Google Scholar
Mollin, D. L. & Ross, G. I. M. (1954). Proc. R. Soc. Med. 47, 428.Google Scholar
Noronha, J. M. & Silverman, M. (1962). In Vitamin B12 and Intrinsic Factor, p. 278 [Heinrich, H. C. editor]. Stuttgart: Enke Verlag.Google Scholar
Perry, J., Lumb, M., Van der Westhuyzen, J., Fernandes-Costa, F., Metz, J. & Chanarin, I. (1979 a). Biochim. biophys Acta 586. 632.Google Scholar
Perry, J., Cumb, M., Van der Westhuyzen, I., Fernandes-Costa, F., Metz, I. & Chanarin, I. (1979 b). In Chemistry and Biology of Pteridines, p. 315 [Kisliuk, R. L. and Brown, G. M. editors]. Amsterdam: Elsevier North Holland Inc.Google Scholar
Retief, F. P., Gottlieb, C. W., Kochwa, S., Pratt, P. W. & Herbert, V. (1967). Blood 29, 501.CrossRefGoogle Scholar
Van der Weyden, M. B., Cooper, F. & Firkin, B. G. (1973). Blood 41, 299.Google Scholar
Van Tonder, S. V., Metz, J. & Green, R. (1975). Br. J. Nutr. 34, 397.Google Scholar
Wickramasinghe, S. N. & Longland, J. E. (1974). Br. med. J. iii, 148.Google Scholar
Wickramasinghe, S. N. & Saunders, J. E. (1976). Scund. J. Huemat. 16, 121.Google Scholar
Wickramasinghe, S. N. & Saunders, J. E. (1977). Acta Huemat. 58, 193.Google Scholar
Wokes, F. & Smith, A. D. M. (1962). In Vitamin B12 and Intrinsic Factor, p. 602 [Heinrich, H. C. editor]. Stuttgart: Enke Verlag.Google Scholar
Zittoun, J., Marquet, J. & Zittoun, R. (1978). Blood 51, 119.Google Scholar