Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-29T05:29:19.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Superoxide dismutase (EC 1.15.1.1), manganese and the effect of ethanol in adult and foetal rats

Published online by Cambridge University Press:  09 March 2007

I. E. Dreosti ,
Susan J. Manuel  and
R. A. Buckley
I. E. Dreosti
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
Susan J. Manuel
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
R. A. Buckley
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, South Australia 5000, Australia
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The activity of manganese-superoxide dismutase (EC 1.15.1; SOD) was increased in the livers and kidneys of adult rats after exposure to aqueous ethanol (200 ml/l) for 32 weeks.

2. The concentration of Mn in the livers and kidneys was significantly higher after 24 weeks, and by 32 weeks liver copper and zinc levels were lower.

3. The activity of foetal (day 19) liver superoxide dismutase was appreciably higher in offspring from dams receiving ethanol during pregnancy. Quantitatively the response appeared to be almost entirely due to the Mn-SOD form of the enzyme.

4. Maternal alcoholism during pregnancy had no effect on the levels of Cu, Mn or Zn in foetal (day 19) livers.

Type
Papers of direct reference to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 48 , Issue 2 , September 1982 , pp. 205 - 210
Copyright
Copyright © The Nutrition Society 1982

References

REFERENCES

Balevska, P. S., Russanov, E. M. & Kassabova, T. A. (1981). Int. J. Biochem. 13, 489.CrossRefGoogle Scholar
Barak, A. J., Beckenhauser, H. C. & Kerrigan, F. J. (1967). Gut 8, 454.CrossRefGoogle Scholar
Cederbaum, A. I., Dicker, E., Rubin, E. & Cohen, G. (1977). Biochem. biophys. Res. Comm. 78, 1254.CrossRefGoogle Scholar
Del Villano, B. C., Tischfield, J. A., Schacter, L. P., Stilwil, D. & Miller, S. I. (1979). Alcoholism clin. expt. Res. 3, 291.CrossRefGoogle Scholar
Diem, K. (editor) (1962). Documenta Geigy, Scientific Tables, p. 165. Basle: Geigy, S. A.Google Scholar
Dreosti, I. E. & Record, I. R. (1979). Br. J. Nutr. 41, 399.CrossRefGoogle Scholar
Dreosti, I. E., Record, I. R., Buckley, R. A., Manuel, S. J. & Fraser, F. J. (1981). In Trace Element Metabolism in Man and Animals (TEM A-4), p. 617 [McC. Howell, J., Gawthorne, J. M. and White, C. L., editors]. Canberra: Australian Academy of Science.CrossRefGoogle Scholar
Fridovich, I. (1975). A. Rev. Biochem. 44, 147.CrossRefGoogle Scholar
Horton, A. A. & Mills, D. J. (1979). Mechan. Ageing Develop. 11, 363.CrossRefGoogle Scholar
Ingelman-Sunderberg, M. & Johansson, I. (1981). J. biol. Chem. 256, 6321.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.CrossRefGoogle Scholar
McCord, J. M. & Fridovich, I. (1969). J. biol. Chem. 244, 6049.CrossRefGoogle Scholar
Misra, H. P. & Fridovich, I. (1977). Archs Biochem. Biophys. 181, 308.CrossRefGoogle Scholar
Paynter, D. L. (1980). J. Nutr. 110, 437.CrossRefGoogle Scholar
Paynter, D. L. (1981). Copper, manganese, selenium and vitamin E interactions in the rat. PhD Thesis, University of Western Australia.Google Scholar
Stevens, J. B. & Autor, A. P. (1977). Lab. Invest. 32, 470.Google Scholar
Thomas, T. N., Priest, D. G. & Zump, J. W. (1976). J. Neurochem. 27, 309.CrossRefGoogle Scholar
Tyler, D. D. (1975). Biochem. J. 147, 493.CrossRefGoogle Scholar
Underwood, E. J. (1977). Trace Elements in Human and Animal Nutrition, 4th ed. New York: Academic Press.Google Scholar
Utsumi, K., Yoshioka, T., Yamanaka, N. & Nakazawa, T. (1977). FEBS Lett. 79, 1.CrossRefGoogle Scholar
Valenzuela, A., Fernandez, V., Fernandez, G., Ugarte, G. & Videla, L. A. (1980). FEBS Lett. 111, 11.CrossRefGoogle Scholar
Vanella, A., Pinturo, R., Grimaldi, R., Tiriolo, P., Di Silvestro, I., Grasso, M., D'Urso, G. & Geremia, E. (1981). IRCS Med. Sci. 9, 144.Google Scholar
Walravens, P. A. (1980). Clin. Chem. 26, 185.CrossRefGoogle Scholar