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Sugar-beet fibre increases cholesterol and reduces bile acid excretion from the small bowel

Published online by Cambridge University Press:  02 April 2007

Anna Maria Langkilde ,
Henrik Andersson  and
Ingvar Bosaeus
Anna Maria Langkilde
Affiliation:
Dept of Clinical Nutrition, The University of Göteborg, Sahlgrenska Hospital, S-413 45, Göteborg, Sweden
Henrik Andersson
Affiliation:
Dept of Clinical Nutrition, The University of Göteborg, Sahlgrenska Hospital, S-413 45, Göteborg, Sweden
Ingvar Bosaeus
Affiliation:
Dept of Clinical Nutrition, The University of Göteborg, Sahlgrenska Hospital, S-413 45, Göteborg, Sweden
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Abstract

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The effect of addition of sugar-beet fibre to the diet on sterol excretion from the small intestine was studied in nine ileostomy subjects. A constant low-fibre diet was given in two 3 d periods with and without 32 g sugar-beet fibre/d in random order. Care was taken to minimize bacterial alteration of the ileostomy contents. The addition of sugar-beet fibre increased net cholesterol excretion by 52 (SE 9)%(P < 0·01), from 294 (SE 99) to 451 (SE 124) mg/d, and decreased bile acid excretion by 26 (SE 15)% (P < 0·01), from 764 (SE 118) to 567 (SE 96) mg/d. The increased cholesterol and decreased bile acid excretion found with sugar-beet fibre addition is different from the pattern associated with fibre sources such as pectin and oat fibre. The interaction between dietary fibre and sterol metabolism may be mediated, therefore, by different mechanisms depending on the fibre source.

Keywords

Dietary fibreBile acidsFaecal steroidsIleostomy
Type
Complex Carbohydrates and Lipid Metabolism
Information
British Journal of Nutrition , Volume 70 , Issue 3 , November 1993 , pp. 757 - 766
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Abraham, Z. D. & Mehta, T. (1988). Three-week psyllium-husk supplementation: effect on plasma cholesterol concentrations, fecal steroid excretion, and carbohydrate absorption in men. American Journal of Clinical Nutrition 41, 61–74.Google Scholar
Anderson, J. W., Deakins, D. A. & Bridges, S. R. (1990). Soluble fiber. Hypocholesterolemic effects and proposed mechanisms. In Dietary Fiber. Chemistry, Physiology and Health Effects, pp. 339–363 [Kritchevsky, D., Bonfield, C. and Anderson, J. W., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Anderson, J. W., Story, L., Sieling, B., Lin Chen, W. L., Petro, M. S. & Story, J. (1984). Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. American Journal of Clinical Nutrition 40, 1146–1155.CrossRefGoogle ScholarPubMed
Asp, N.-G. (1990). Delimitation problems in definition and analysis of dietary fiber. In New Developments in Dietary Fiber. [Furda, I. and Brine, J., editors]. New York: Plenum Press.Google Scholar
Bosaeus, I. & Anderson, H. (1990). The effect of fat quality on intestinal steroid excretion. Näringsforskning 34, 51–55.Google Scholar
Bosaeus, I., Carlsson, N.-G., Sandberg, A.-S. & Anderson, H. (1986). Effects of wheat bran and pectin on bile acid and cholesterol excretion in ileostomy patients. Human Nutrition 40C, 429–440.Google Scholar
Eastwood, M. A. & Hamilton, D. (1968). Studies on the adsorption of bile salts to non-absorbed components of diet. Biochimica et Biophysica Acta 152, 165–173.CrossRefGoogle ScholarPubMed
Eastwood, M. & Mowbray, L. (1976). The binding of the components of mixed micelle to dietary fiber. American Journal of Clinical Nutrition 29, 1461–1467.CrossRefGoogle ScholarPubMed
Ebihara, K. & Schneeman, B. (1989). Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. Journal of Nutrition 119, 1100–1106.CrossRefGoogle ScholarPubMed
Falk, J. D. & Nagyvary, J. J. (1982). Exploratory studies of lipid-pectin interactions. Journal of Nutrition 112, 182–188.CrossRefGoogle ScholarPubMed
Hagander, B., Asp, N.-G., Efendic, S., Nilsson-Ehle, P. & Scherstén, B. (1988). Dietary fiber decreases fasting blood glucose levels and plasma LDL concentration in noninsulin-dependent diabetes mellitus patients. American Journal of Clinical Nutrition 47, 852–858.CrossRefGoogle ScholarPubMed
Hagander, B., Asp, N.-G., Ekman, R., Nilsson-Ehle, P. & Scherstén, B. (1989). Dietary fibre enrichment, blood pressure, lipoprotein profile and gut hormones in NIDDM patients. European Journal of Clinical Nutrition 43, 35–44.Google ScholarPubMed
Heaton, K. W. (1987). Dietary fibre and bile salts. Scandinavian Journal of Gastroenterology 22, Suppl. 129, 172–173.CrossRefGoogle Scholar
Heaton, K. W. & Pomare, E. W. (1974). Effect of bran on blood lipids and calcium. Lancet i, 49–50.CrossRefGoogle Scholar
Israelsson, B., Järnblad, G. & Persson, K. (1988). Serum cholesterol reduced with Fibrex®, a sugar-beet fibre preparation. In Dietetics in the 90s, pp. 167–170 [Moyal, M. F., editor]. London: John Libbey Eurotext Ltd.Google Scholar
Jenkins, D. J. A., Leeds, A. R., Newton, C. & Cummings, J. H. (1975). Effect of pectin, guar gum and wheat fibre on serum cholesterol. Lancet i, 1116–1117.CrossRefGoogle Scholar
Jenkins, D. J. A., Leeds, A. R., Slavin, B. & Jepson, E. M. (1976). Guar gum in hyperlipidaemia. Lancet ii, 1351.CrossRefGoogle Scholar
Johnson, I. T., Livesey, G., Gee, J. M., Brown, J. C. & Wortley, G. M. (1990). The biological effects and digestible energy value of a sugar-beet fibre preparation in the rat. British Journal of Nutrition 64, 187–199.CrossRefGoogle ScholarPubMed
Judd, P. A. & Truswell, A. S. (1982). Comparison of the effects of high- and low-methoxyl pectins on blood and faecal lipids in man. British Journal of Nutrition 48, 451–458.CrossRefGoogle ScholarPubMed
Kay, R. M. & Truswell, A. S. (1977). Effect of citrus pectin on blood lipids and fecal steroid excretion in man. American Journal of Clinical Nutrition 30, 171–175.CrossRefGoogle ScholarPubMed
Keenan, M. H. J., Belton, P. S., Matthew, J. A. & Howson, S. J. (1985). A 13C-n.m.r. study of sugar-beet pectin. Carbohydrate Research 138, 168–170.CrossRefGoogle Scholar
Kritchevsky, D. (1978). Influence of dietary fiber on bile acid metabolism. Lipids 13, 982–985.CrossRefGoogle ScholarPubMed
Lampe, J. W., Slavin, J. L., Baglien, K. S., Thompson, W. O., Duane, W. C. & Zavoral, J. H. (1991). Serum lipid and fecal bile acid changes with cereal, vegetable, and sugar-beet fiber feeding. American Journal of Clinical Nutrition 53, 1235–1241.CrossRefGoogle ScholarPubMed
Langkilde, A. M., Anderson, H., Schweizer, T. F. & Torsdottir, I. (1990). Nutrients excreted in ileostomy effluents after consumption of mixed diets with beans or potatoes. I. Minerals, protein, fat and energy. European Journal of Clinical Nutrition 44, 559–566.Google ScholarPubMed
McLean Baird, I., Walters, R. L., Davies, P. S., Hill, M. J., Drasar, B. S. & Southgate, D. A. T. (1977). The effects of two dietary fiber supplements on gastrointestinal transit, stool weight and frequency, and bacterial flora, and fecal bile acids in normal subjects. Metabolism 26, 117–129.CrossRefGoogle Scholar
Miettinen, T. A. & Tarpila, S. (1977). Effect of pectin on serum cholesterol, fecal bile acids and biliary lipids in normolipidemic and hyperlipidemic individuals. Clinica Chimica Acta 79, 471–477.CrossRefGoogle ScholarPubMed
National Food Administration (1988). Livsmedelstabeller. Swedish Food Composition Tables. Uppsala: Statens livsmedelsverk.Google Scholar
Pfeffer, P. E., Doner, L. W., Hoagland, P. D. & McDonald, G. G. (1981). Molecular interactions with dietary fiber components. Investigation of the possible association of pectin and bile acids. Journal of Agricultural and Food Chemistry 29, 455–461.CrossRefGoogle ScholarPubMed
Reddy, B. S., Watanabe, K. & Sheinfil, A. (1980). Effect of dietary wheat bran, alfalfa, pectin and carrageenan on plasma cholesterol and fecal bile acid and neutral sterol excretion in rats. Journal of Nutrition 110, 1247–1254.CrossRefGoogle ScholarPubMed
Rombouts, F. M. & Thibault, J.-F. (1986). Feruloylated pectic substances from sugar beet pulp. Carbohydrate Research 154, 177–187.CrossRefGoogle Scholar
Sandberg, A.-S., Anderson, H., Hallgren, B., Hasselblad, K. & Isaksson, B. (1981). Experimental model for in vivo determination of dietary fibre and its effect on the absorption of nutrients in the small intestine. Journal of Nutrition 45, 283–294.CrossRefGoogle ScholarPubMed
Stasse-Wolthuis, M., Hautvast, J. G. A. J., Hermus, R. J. J., Katan, M. B., Bausch, J. E., Rietberg-Brussard, J. H., Velema, J. P., Zondervan, J. H., Eastwood, M. A. & Brydon, W. G. (1979). The effect of a natural high-fiber diet on serum lipids, fecal lipids, and colonic function. American Journal of Clinical Nutrition 32, 1881–1888.CrossRefGoogle ScholarPubMed
Story, J. A. & Lord, S. L. (1987). Bile salts: In vitro studies with fibre components. Scandinavian Journal of Gastroenterology 22, Suppl. 129, 174–180.CrossRefGoogle Scholar
Tornquist, H., Rissanen, A. & Anderson, H. (1986). Balance studies in patients with intestinal resection. How long is enough? British Journal of Nutrition 56, 11–16.CrossRefGoogle Scholar
Tredger, J. A., Morgan, L. M., Travis, J. & Marks, V. (1991). The effects of guar gum, sugar beet fibre and wheat bran supplementation on serum lipoprotein levels in normocholesterolaemic volunteers. Journal of Human Nutrition and Dietetics 4, 375–384.CrossRefGoogle Scholar
Truswell, A. S. & Beynen, A. C. (1992). Dietary fibre and plasma lipids: Potential for prevention and treatment of hyperlipidemias. In Dietary Fibre - a Component of Food, pp. 295–332 [Schweizer, T. F. and Edwards, C. A., editors]. London: Springer Verlag Ltd.CrossRefGoogle Scholar
Truswell, A. S. & Kay, R. M. (1975). Absence of effect of wheat bran on blood lipids. Lancet i, 922–923.CrossRefGoogle Scholar
Walters, R. L., McLean Baird, I., Davies, P. S., Hill, M. J., Drasar, B. S., Southgate, D. A. T., Green, J. & Morgan, B. (1975). Effects of two types of dietary fibre on faecal steroid and lipid excretion. British Medical Journal 2, 536–538.CrossRefGoogle ScholarPubMed
Vahouny, G. V., Satchithanandam, S., Chen, I., Tepper, S. A., Kritchevsky, D., Lightfoot, F. G. & Cassidy, M. M. (1988). Dietary fiber and intestinal adaptation: effects on lipid absorption and lymphatic transport in the rat. American Journal of Clinical Nutrition 47, 201–206.CrossRefGoogle ScholarPubMed
Vahouny, G. V., Tombes, R., Cassidy, M. M., Kritchevsky, D. & Gallo, L. L. (1980). Dietary fibers: V. Binding of bile salts, phospholipids and cholesterol from mixed micelles by bile acid sequestrants and dietary fibers. Lipids 15, 1012–1018.CrossRefGoogle ScholarPubMed
van der Kamer, J. H., ten Bokkel Huinink, H. & Weyers, H. A. (1949). Rapid method for the determination of fat in feces. Journal of Biological Chemistry 177, 347–355.CrossRefGoogle Scholar