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Some effects of selenium deficiency on glutathione peroxidase (EC 1.11.1.9) activity and tissue pathology in rainbow trout (Salmo gairdneri)

Published online by Cambridge University Press:  09 March 2007

J. G. Bell ,
B. J. S. Pirie ,
J. W. Adron  and
C. B. Cowey
J. G. Bell
Affiliation:
Institute of Marine Biochemistry, St Fittick's Road, Aberdeen AB1 3RA
B. J. S. Pirie
Affiliation:
Institute of Marine Biochemistry, St Fittick's Road, Aberdeen AB1 3RA
J. W. Adron
Affiliation:
Institute of Marine Biochemistry, St Fittick's Road, Aberdeen AB1 3RA
C. B. Cowey
Affiliation:
Institute of Marine Biochemistry, St Fittick's Road, Aberdeen AB1 3RA
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Abstract

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1. Two duplicate groups of rainbow trout (Sulmo gairdneri; mean weight 27 g) were given diets of differing selenium content (deficient 0, 025 mg Se/kg; supplemented 1.022 mg Se/kg) for 30 weeks.

2. There were no significant differences between treatments in weight gain but packed cell volume, liver vitamin E and liver and plasma Se concentrations were all significantly lower in the Se-deficient trout.

3. Ataxia occurred in about 10% of the Se-deficient trout and histopathologies were evident in nerve cord (damage to axon sheath) and liver (loss of integrity in endoplasmic reticulum and mitochondria with appearance of increased vesiculation).

4. Glutathione peroxidase (EC 1.11.1.9) activity was significantly reduced in liver and plasma of Se-deficient fish but there was no indication, from differential assay, of any non-Se-dependent glutathione peroxidase activity. Glutathione transferase (EC 2.5. I.18) activity was significantly increased in Se-deficient trout.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 2 , March 1986 , pp. 305 - 311
Copyright
Copyright © The Nutrition Society 1986

References

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