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Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium

Published online by Cambridge University Press:  08 March 2007

Myriam Myriam ,
Magalie Sabatier ,
Heike Steiling  and
Gary Williamson
Myriam Myriam*
Affiliation:
Nestec Ltd, PO Box 44, CH-1000 Lausanne 26, NestléResearch Center, Switzerland
Magalie Sabatier
Affiliation:
Nestec Ltd, PO Box 44, CH-1000 Lausanne 26, NestléResearch Center, Switzerland
Heike Steiling
Affiliation:
Nestec Ltd, PO Box 44, CH-1000 Lausanne 26, NestléResearch Center, Switzerland
Gary Williamson
Affiliation:
Nestec Ltd, PO Box 44, CH-1000 Lausanne 26, NestléResearch Center, Switzerland
*
*Corresponding author: Dr M. Richelle, fax +41 21 785 85 44, email: [email protected]
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Abstract

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Dietary bioactive compounds (vitamin E, carotenoids, polyphenols, vitamin C, Se and Zn) have beneficial effects on skin health. The classical route of administration of active compounds is by topical application direct to the skin, and manufacturers have substantial experience of formulating ingredients in this field. However, the use of functional foods and oral supplements for improving skin condition is increasing. For oral consumption, some dietary components could have an indirect effect on the skin via, for example, secondary messengers. However, in the case of the dietary bioactive compounds considered here, we assume that they must pass down the gastrointestinal tract, cross the intestinal barrier, reach the blood circulation, and then be distributed to the different tissues of the body including the skin. The advantages of this route of administration are that the dietary bioactive compounds are metabolized and then presented to the entire tissue, potentially in an active form. Also, the blood continuously replenishes the skin with these bioactive compounds, which can then be distributed to all skin compartments (i.e. epidermis, dermis, subcutaneous fat and also to sebum). Where known, the distribution and mechanisms of transport of dietary bioactive compounds in skin are presented. Even for compounds that have been studied well in other organs, information on skin is relatively sparse. Gaps in knowledge are identified and suggestions made for future research.

Keywords

BioavailabilitySkinVitamin ETocopherolVitamin CAscorbateCarotenoidPolyphenolZincSelenium
Type
Review Article
Information
British Journal of Nutrition , Volume 96 , Issue 2 , August 2006 , pp. 227 - 238
Copyright
Copyright © The Nutrition Society 2006

References

Ackland, ML, Danks, DM & McArdle, HJStudies on the mechanism of zinc uptake by human fibroblasts. J Cell Physiol (1988) 135, 521–526.CrossRefGoogle ScholarPubMed
Alaluf, S, Heinrich, U, Stahl, W, Tronnier, H & Wiseman, SDietary carotenoids contribute to normal human skin color and UV photosensitivity. J Nutr (2002) 132, 399–403.CrossRefGoogle ScholarPubMed
Baer, MT & King, JCTissue zinc levels and zinc excretion during experimental zinc depletion in young men. Am J Clin Nutr (1984) 39, 556–570.CrossRefGoogle ScholarPubMed
Baer, MT, King, JC, Tamura, T, Margen, S, Bradfield, RB, Weston, WL & Daugherty, NANitrogen utilization, enzyme activity, glucose intolerance and leukocyte chemotaxis in human experimental zinc depletion. Am J Clin Nutr (1985) 41, 1220–1235.CrossRefGoogle ScholarPubMed
Beehler, BC, Przybyszewski, J, Box, HB & Kulesz-Martin, MFFormation of 8-hydroxydeoxyguanosine within DNA of mouse keratinocytes exposed in culture to UVB and H2O2. Carcinogenesis (1992) 13, 2003–2007.CrossRefGoogle ScholarPubMed
Behne, D, Hilmert, H, Scheid, S, Gessner, H & Elger, WEvidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta (1988) 966, 12–21.CrossRefGoogle ScholarPubMed
Boileau, TW, Boileau, AC & Erdman, JW Jr Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med (Maywood) (2002) 227, 914–919.CrossRefGoogle ScholarPubMed
Bone, RA, Landrum, JT, Fernandez, L & Tarsis, SLAnalysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci (1988) 29, 843–849.Google ScholarPubMed
Bone, RA, Landrum, JT, Friedes, LM, Gomez, CM, Kilburn, MD, Menendez, E, Vidal, I & Wang, WDistribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res (1997) 64, 211–218.CrossRefGoogle ScholarPubMed
Brown, LAS & Jones, DP The biology of ascorbic acid. In Handbook of Antioxidants, pp. 117–154. [E, Cadenas & L, Packer editors.] New York: Marcel Dekker Inc. (1996)Google Scholar
Burk, RF & Hill, KESelenoprotein P. A selenium-rich extracellular glycoprotein. J Nutr (1994) 124, 1891–1897.CrossRefGoogle ScholarPubMed
Burk, RF & Hill, KESelenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr (2005) 25, 215–235.CrossRefGoogle Scholar
Cesarini,, JP, Michel, L, Maurette, JM, Adhoute, H & Bejot, MImmediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed (2003) 19, 182–189.CrossRefGoogle ScholarPubMed
Clinton, SK, Emenhiser, C, Schwartz, SJ, Bostwick, DG, Williams, AW, Moore, BJ & Erdman, JWCis-trans lycopene isomers, carotenoids and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev (1996) 5, 823–833.Google ScholarPubMed
Cooper, DA, Webb, DR & Peters, JCEvaluation of the potential for olestra to affect the availability of dietary phytochemicals. J Nutr (1997) 127, Suppl., 1699S–1709S.CrossRefGoogle ScholarPubMed
Cross, CE, van der Vliet, A, Louie, S, Thiele, JJ & Halliwell, BOxidative stress and antioxidants at biosurfaces: plants, skin, and respiratory tract surfaces. Environ Health Perspect (1998) 106, 1241–1251.Google ScholarPubMed
Dalle, CM & Pathak, MASkin photosensitizing agents and the role of reactive oxygen species in photoaging. J Photochem Photobiol B (1992) 14, 105–124.Google Scholar
Darvin, ME, Gersonde, I, Meinke, M, Sterry, W & Landemann, JNon-invasive in vivo determination of the carotenoids b-carotene and lycopene concentrations in the human skin using the Raman spectroscopic method. J Phys D Appl Phys (2005) 38, 2696–2700.CrossRefGoogle Scholar
Day, AJ, Canada, FJ, Diaz, JC, Kroon, PA, McLauchlan, WR, Faulds, CB, Plumb, GW, Morgan, MRA, Williamson, GDietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett (2000) 468, 166–170.CrossRefGoogle ScholarPubMed
Day, AJ, Mellon, FA, Barron, D, Sarrrazin, GMorgan, MRAWilliamson, GHuman metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res (2001) 212, 941–952.CrossRefGoogle Scholar
Downing, DT, Stewart, ME & Strauss, JSEstimation of sebum production rates in man by measurement of the squalene content of skin biopsies. J Invest Dermatol (1981) 77, 358–360.CrossRefGoogle Scholar
During, A, Dawson, HD & Harrison, EHCarotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr (2005) 135, 2305–2312..CrossRefGoogle ScholarPubMed
During, A, Hussain, MM, Morel, DW & Harrison, EHCarotenoid uptake and secretion by CaCo-2 cells: b-carotene isomer selectivity and carotenoid interactions. J Lipid Res (2002) 43, 1086–1095.CrossRefGoogle Scholar
Emerit, IFree radicals and aging of the skin. EXS (1992) 62, 328–341.Google ScholarPubMed
Evans, GWNormal and abnormal zinc absorption in man and animals: the tryptophan connection. Nutr Rev (1980) 38, 137–141.CrossRefGoogle ScholarPubMed
Ford, DIntestinal and placental zinc transport pathways. Proc Nutr Soc (2004) 63, 21–29.CrossRefGoogle ScholarPubMed
Fuchs, JPotential and limitation of the natural antioxidants RRR a tocopherol, L-ascorbic acid and b-carotene in cutaneaous photoprotection. Free Radic Biol Med (1998) 25, 848–873.CrossRefGoogle Scholar
Fuchs, J & Kern, HModulation of UV-light-induced skin inflammation by D-a-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med (1998) 25, 1006–1012.CrossRefGoogle Scholar
Fuchs, J & Podda, M (1997) Vitamin C in cutaneous biology. In Vitamin C in Health and Disease, pp. 333–340. [Packer, L and Fuchs, J, editors]. New York: Marcel Dekker Inc.Google Scholar
Gollnick, HPM, Hopfenmuller, W, Hemmes, C, Chun, SC, Schmid, C, Sundermeier, K & Biesalski, HCSystemic b carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the Berlin-Eilath study. Eur J Dermatol (1996) 6, 200–205.Google Scholar
Greul, AK, Grundmann, JU, Heinrich, F, Pfitzincer, I, Bernhardt, J, Ambach, A, Biesalski, HK & Gollnick, HPhotoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol (2002) 15, 307–315.CrossRefGoogle Scholar
Guiraud, P, Lepee, M, Monjo, AM, Richard, MJ & Favier, ACultured human skin fibroblasts absorb 65Zn. Optimization of the method and study of the mechanisms involved. Biol Trace Elem Res (1992) 32, 213–225.CrossRefGoogle ScholarPubMed
Guyton, KZ & Kensler, TWOxidative mechanisms in carcinogenesis. Br Med Bull (1993) 49, 523–544.CrossRefGoogle ScholarPubMed
Hallman, PS, Perrin, DD & Watt, AEThe computed distribution of Cu (II) and zinc (II) ions among seventeen amino acids present in human blood plasma. Biochem J (1971) 121, 549–555.CrossRefGoogle ScholarPubMed
Hambidge, K, Casey, C & Krebs, N Zinc In Trace Elements in Human and Animal Nutrition. pp. 1–137 [W, Mertz editor]. New York: Academic Press (1986)Google Scholar
Hammond, BR & Wooten, BRResonance Raman spectroscopic measurement of carotenoids in the skin and retina. J Biomed Opt (2005) 10, (5), 054002 (12 pages).CrossRefGoogle ScholarPubMed
Handelman, GJ, Dratz, EA, Reay, CC & van Kuijk, FJGMCarotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci (1988) 29, 850–855.Google ScholarPubMed
Hata, TR, Scholz, TA, Ermakov, IV, McClane, RW, Khachik, F, Gellermann, W & Pershing, LKNon-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol (2000) 115, 441–448.CrossRefGoogle ScholarPubMed
Heinrich, U, Gartner, C, Wiebusch, M, Eichler, OSies, HTronnier, H & Stahl, WSupplementation with β–carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr (2003) 133, 98–101.CrossRefGoogle ScholarPubMed
Hollander,, D, Rim, E & Muralidhara, KSMechanism and site of small intestinal absorption of a-tocopherol in the rat. Gastroenterology (1975) 68, 1492–1499.CrossRefGoogle Scholar
Hollander, D & Ruble, PEβ–Carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on transport. Am J Physiol (1978) 235, E686–E691.Google ScholarPubMed
Hosomi, A, Arita, M, Sato, Y, Kiyose, CUeda, TIgarashi, O, Arai, H, Inoue, KAffinity for a-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett (1997) 409, 105–108.CrossRefGoogle Scholar
Hu, ML & Tappel, ALPotentiation of oxidative damage to proteins by ultraviolet-A and protection by antioxidant. Photochem Photobiol (1992) 56, 357–363.CrossRefGoogle Scholar
Jackson, MJ Physiology of zinc: general aspects In Zinc in Human Biology. pp. 1–14 [CF, Mills editor]. London: Springer-Verlag. (1989)Google Scholar
Jang, M, Cai, L, Udeani, GOet al.. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 275, 218–220.CrossRefGoogle ScholarPubMed
Jungmann, H, Heinrich, U, Wiebusch, M & Tronnier, HDer einsatz der reflektionsspektroskopie in der dermatologie am beispiel der β–carotins. Kosmet Med (1996) 1, 50–57.Google Scholar
Kamimura, A & Takahashi, TProcyanidin B-2, extracted from apples, promotes hair growth: a laboratory study. Br J Dermatol (2002) 146, 41–51.CrossRefGoogle ScholarPubMed
Katiyar, SK, Agarwal, R & Mukhtar, HInhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res (1996) 56, 1023–1030.Google ScholarPubMed
Katiyar, SK & Mukhtar, HTea antioxidants in cancer chemoprevention. J Cell Biochem (1997) 27, 59–67.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Kenny, TP, Keen, CL, Jones, P, Kung, HJSchmitz, HH & Gershwin, MECocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2.. Exp Biol Med (Maywood) (2004) 229, 765–771.CrossRefGoogle ScholarPubMed
King, JC, Shames, DM & Woodhouse, LRZinc homeostasis in humans. J Nutr (2000) 130, Suppl., 1360S–1366S.CrossRefGoogle ScholarPubMed
Krinsky, NI & Deneke, SMInteraction of oxygen and oxy-radicals with carotenoids. J Natl Cancer Inst (1982) 69, 205–210.Google ScholarPubMed
Krinsky, NI, Russett, MD, Handelman, GJ & Snodderly, DMStructural and geometrical isomers of carotenoids in human plasma. J Nutr (1990) 120, 1654–1662.CrossRefGoogle ScholarPubMed
Kroon, PA, Clifford, MN, Crozier, A, Day, AJ, Donovan, JL, Manach, C & Williamson, GHow should we assess the effects of exposure to dietary polyphenols in vitro?. Am J Clin Nutr (2004) 80, 15–21.CrossRefGoogle ScholarPubMed
Lang, JK, Gohil, K, Packer, LSimultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem (1986) 157, 106–116.CrossRefGoogle ScholarPubMed
Leccia, MT, Richard, MJ, Joanny-Crisci, F & Beani, JCUV-A1 cytotoxicity and antioxidant defence in keratinocytes and fibroblasts. Eur J Dermatol (1998) 8, 478–482.Google ScholarPubMed
Leveque, N, Robin, S, Muret, P, Mac-Mary, S, Makki, S & Humbert, PHigh iron and low ascorbic acid concentrations in the dermis of atopic dermatitis patients. Dermatology (2003) 207, 261–264.CrossRefGoogle ScholarPubMed
Liang, WJ, Johnson, D & Jarvis, SMVitamin C transport systems of mammalian cells.. Mol Membr Biol (2001) 18, 87–95.CrossRefGoogle ScholarPubMed
McKenzie, RCSelenium, ultraviolet radiation and the skin. Clin Exp Dermatol (2000) 25, 631–636.CrossRefGoogle ScholarPubMed
Manach, C, Williamson, G, Morand, C, Scalbert, A & Remesy, CBioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr (2005) 81, Suppl., 230S–242S.CrossRefGoogle ScholarPubMed
Miller, LV, Hambidge, KM, Naake, VL, Hong, ZWestcott, JL & Fennessey, PVSize of the zinc pools that exchange rapidly with plasma zinc in humans: alternative techniques for measuring and relation to dietary zinc intake. J Nutr (1994) 124, 268–276.CrossRefGoogle ScholarPubMed
Mittal, A, Elmets, CA & Katiyar, SKDietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis (2003) 24, 1379–1388.CrossRefGoogle ScholarPubMed
Molokhia, MM & Portnoy, BNeutron activation analysis of trace elements in skin. 3. Zinc in normal skin. Br J Dermatol (1969) 81, 759–762.CrossRefGoogle ScholarPubMed
Molokhia, A, Portnoy, B & Dyer, ANeutron activation analysis of trace elements in skin. VIII. Selenium in normal skin. Br J Dermatol (1979) 101, 567–572.CrossRefGoogle ScholarPubMed
Moser, U & Bendich, A (1991) Vitamin C. In Handbook of Vitamins, pp. 195–195 [LJ, Machlin editor]. New York: Marcel Dekker Inc.Google Scholar
Mukhtar, H & Ahmad, NCancer chemoprevention: future holds in multiple agents. Toxicol Appl Pharmacol (1999) 158, 207–210.CrossRefGoogle ScholarPubMed
Nemeth, K, Plumb, GW, Berrin, JG, Juge, N, Jacob, R, Naim, HY,Williamson, G, Swallow, DM & Kroon, PADeglycosylation by small intestinal epithelial cell β–glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr (2003) 42, 29–42.CrossRefGoogle ScholarPubMed
Ni, Z, Mu, Y & Gulati, OTreatment of melasma with Pycnogenol. Phytother Res (2002) 16, 567–571.CrossRefGoogle ScholarPubMed
O’Leary, KA, Day, AJ, Needs, PW, Mellon, FAO’Brien, NM & Williamson, GMetabolism of quercetin–7–and quercetin–3–glucuronides by an in vitro hepatic model: the role of human b-glucuronidase, sulfotransferase, catechol–O–methyltransferase and multi–resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol (2003) 65, 479–491.CrossRefGoogle Scholar
Oster, O, Schmiedel, G & Prellwitz, WThe organ distribution of selenium in German adults. Biol Trace Elem Res (1988) 15, 23–45.CrossRefGoogle ScholarPubMed
Pasqualini, JR & Nguyen, BLEstrone sulfatase activity and effect of antiestrogens on transformation of estrone sulfate in hormone-dependent vs independent human breast–cancer cell-lines. Breast Cancer Res Treat (1991) 18, 93–98.CrossRefGoogle ScholarPubMed
Perchellet, JP & Perchellet, EMAntioxidants and multistage carcinogenesis in mouse skin. Free Radic Biol Med (1989) 7, 377–408.CrossRefGoogle ScholarPubMed
Perchellet, JP, Perchellet, EM & Belman, SInhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils. Nutr Cancer (1990) 14, 183–193.CrossRefGoogle ScholarPubMed
Podda, M, Traber, MG, Weber, C, Yan, LJ & Packer, LUVirradiation depletes antioxidants and causes oxidative damage in a model of human skin. Free Radic Biol Med (1998) 24, 55–65.CrossRefGoogle Scholar
Postaire, E, Jungmann, H, Bejot, M, Heinrich, U & Tronnier, HEvidence for antioxidant nutrients-induced pigmentation in skin: results of a clinical trial. Biochem Mol Biol Intern (1997) 42, 1023–1033.Google ScholarPubMed
Prasad, A Clinical and biochemical spectrum of zinc deficiency in human subjects In Clinical, Biochemical, and Nutritional Aspects of Trace Elements pp. 3–62 [AS, Prasadeditor]. New York: Alan R. Liss (1982)Google Scholar
Proteggente, AR, Basu-Modak, S, Kuhnle, G, Gordon, MJ, Youdim, K, Tyrrell, R & Rice-Evans, CAHesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts. Photochem Photobiol (2003) 78, 256–261.2.0.CO;2>CrossRefGoogle ScholarPubMed
Rafferty, TS, McKenzie, RC, Hunter, JA, Howie, AFArthur, JRNicol, F & Beckett, GJDifferential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death. Biochem J (1998) 332, 231–236.CrossRefGoogle ScholarPubMed
Re, R, Fraser, PD, Long, M, Bramley, PM & Rice-Evans, CIsomerization of lycopene in the gastric milieu. Biochem Biophys Res Commun (2001) 281, 576–581.CrossRefGoogle ScholarPubMed
Reboul, E, Abou, L, Mikail, C, Ghiringhelli, OAndre, MPortugal, H, Jourdheuil-Rahmani, D, Amiot, MJ, Lairon, D & Borel, PLutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). Biochem J (2004) 387, 455–461.CrossRefGoogle Scholar
Ribaya-Mercado, JD, Garmyn, M, Gilchrest, BA & Russell, RMSkin lycopene is destroyed preferentially over β–carotene during ultraviolet irradiation in humans. J Nutr (1995) 125, 1854–1858.CrossRefGoogle ScholarPubMed
Richardson, DRMore roles for selenoprotein P: local selenium storage and recycling protein in the brain. Biochem J (2005) 386, e5–e7.CrossRefGoogle ScholarPubMed
Rios, L, Bennett, RN, Lazarus, SA, Remesy, CScalbert, A & Williamson, GCocoa proanthocyanidins are stable during gastric transit in humans. Am J Clin Nutr (2002) 76, 1106–1110.CrossRefGoogle ScholarPubMed
Rostan, EF, DeBuys, HV, Madey, DL, Pinnell, SREvidence supporting zinc as an important antioxidant for skin. Int J Dermatol (2002) 41, 606–611.CrossRefGoogle ScholarPubMed
Rumsey, SC & Levine, MAbsorption, transport, and disposition of ascorbic acid in humans. J Nutr Biochem (1998) 9, 116–160.CrossRefGoogle Scholar
Sadhana, AS, Rao, AR, Kucheria, K & Bijani, VInhibitory action of garlic oil on the initiation of benzo[a]pyrene-induced skin carcinogenesis in mice. Cancer Lett (1988) 40, 193–197.CrossRefGoogle Scholar
Savini, I, Catani, MV, Rossi, A, Duranti, GMelino, G & Avigliano, LCharacterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis. J Invest Dermatol (2002) 118, 372–379.CrossRefGoogle ScholarPubMed
Savini, I, D’Angelo, I, Ranalli, M, Melino, G & Avigliano, LAscorbic acid maintenance in HaCaT cells prevents radical formation and apoptosis by UV-B. Free Radic Biol Med (1999) 26, 1172–1180.CrossRefGoogle ScholarPubMed
Savini, I, Duflot, S & Avigliano, LDehydroascorbic acid uptake in a human keratinocyte cell line (HaCaT) is glutathione-independent. Biochem J (2000) 345, 665–672.CrossRefGoogle Scholar
Schallreuter, KU, Hordinsky, MK & Wood, JMThioredoxin reductase. Role in free radical reduction in different hypopigmentation disorders. Arch Dermatol (1987) 123, 615–619.CrossRefGoogle ScholarPubMed
Schierle, J, Bretzel, W, Bühler, I, Faccin, N, Hess, D, Steiner, K & Schüep, WContent and isomeric ratio of lycopene in food and human plasma. Food Chem (1997) 59, 459–465.CrossRefGoogle Scholar
Schiffer, R, Neis, M, Holler, D et al. . Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes. J Invest Dermatol (2003) 120, 285–291.CrossRefGoogle ScholarPubMed
Shindo, Y, Witt, E, Han, D, Epstein, W & Packer, LEnzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol (1994) 102, 122–124.CrossRefGoogle ScholarPubMed
Singh, RP & Agarwal, RFlavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal (2002) 4, 655–663.CrossRefGoogle ScholarPubMed
Sotiriou, S, Gispert, S, Cheng, J, Wang, Y, Chen, A, Hoogstraten-Miller, S, Miller, GF, Kwon, O, Levine, M, Guttentag, SH & Nussbaum, RLAscorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med (2002) 8, 514–517.CrossRefGoogle ScholarPubMed
Stahl, W, Heinrich, U, Jungmann, H, Sies, H & Tronnier, HCarotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr (2000) 71, 795–798.CrossRefGoogle ScholarPubMed
Stahl, W, Heinrich, U, Jungmann, H, von Laar, J, Schietzel, M, Sies, H & Tronnier, HIncreased dermal carotenoid levels assessed by noninvasive reflection spectrometry correlate with serum levels in women ingesting betatene. J Nutr (1998) 128, 903–907.CrossRefGoogle ScholarPubMed
Stahl, W, Heinrich, U, Wiseman, S, Eichler, O, Sies, H & Tronnier, HDietary tomato paste protects against ultraviolet lightinduced erythema in humans. J Nutr (2001) 131, 1449–1451.CrossRefGoogle ScholarPubMed
Stahl, W, Schwarz, W, Sundquist, AR & Sies, HCis-trans isomers of lycopene and b-carotene in human serum and tissues. Arch Biochem Biophys (1992) 294, 173–177.CrossRefGoogle Scholar
Stahl, W & Sies, HUptake of lycopene and its geometrical isomers is greater from heat processed than from unprocessed tomato juice in humans. J Nutr (1992) 122 (11), 2161–2166.CrossRefGoogle ScholarPubMed
Stahl, W & Sies, HLycopene: a biologically important carotenoid for humans?. Arch Biochem Biophys (1996) 336, 1–9.CrossRefGoogle ScholarPubMed
Stahl, W & Sies, HCarotenoids and protection against solar UV radiation. Skin Pharmacol Appl Skin Physiol (2002) 15, 291–296.CrossRefGoogle ScholarPubMed
Steenvoorden, DP & van Henegouwen, GMThe use of endogenous antioxidants to improve photoprotection. J Photochem Photobiol B (1997) 41, 1–10.CrossRefGoogle ScholarPubMed
Stoner, GD & Mukhtar, HPolyphenols as cancer chemopreventive agents. J Cell Biochem Suppl (1995) 22, 169–180.CrossRefGoogle ScholarPubMed
Suganuma, M, Okabe, S, Oniyama, M, Tada, Y, Ito, H & Fujiki, HWide distribution of [3H]–epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue. Carcinogenesis (1998) 19, 1771–1776.CrossRefGoogle ScholarPubMed
Tapiero, H & Tew, KDTrace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother (2003) 57, 399–411.CrossRefGoogle ScholarPubMed
Thiele, JJ, Dreher, F & Packer, L Cosmeceuticals. Drugs vs Cosmetics, pp. 145–188 [Elsner, P and Maibach, H, editors]. New York: Dekker. (2000)Google Scholar
Thiele, JJ, Podda, M & Packer, LTropospheric ozone: an emerging environmental stress to skin. Biol Chem (1997) 378, 1299–1305.Google ScholarPubMed
Thiele, JJ, Traber, MG & Packer, LDepletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidation. J Invest Dermatol (1998) 110, 756–761.CrossRefGoogle ScholarPubMed
Thiele, JJ, Weber, SU & Packer, LSebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J Invest Dermatol (1999) 113, 1006–1010.Google Scholar
Tsukaguchi, H, Tokui, T, Mackenzie, B, Berger, UV, Chen, XZ, Wang, Y, Brubaker, RF & Hediger, MAA family of mammalian Na+-dependent L-ascorbic acid transporters. Nature (1999) 399, 70–75.CrossRefGoogle ScholarPubMed
Vaule, H, Leonard, SW & Traber, MGVitamin E delivery to human skin: studies using deuterated a-tocopherol measured by APCI LC-MS. Free Radic Biol Med (2004) 36, 456–463.CrossRefGoogle Scholar
Wang, K, Zhou, B, Kuo, YM, Zemansky, J & Gitschier, JA novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet (2002) 71, 66–73.CrossRefGoogle ScholarPubMed
Weber, SU, Thiele, JJ, Cross, CE & Packer, LVitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure. J Invest Dermatol (1999) 113, 1128–1132.CrossRefGoogle ScholarPubMed
Widyarini, S, Husband, AJ & Reeve, VEProtective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen. Photochem Photobiol (2005) 81, 32–37.CrossRefGoogle ScholarPubMed
Wie, H, Saladi, R, Lu, Y, Wang, Y, Palep, SR, Moore, J, Phelps, R, Shyong, E & Lebwohl, MGIsoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr (2003) 133, Suppl., 3811S–3819S.Google Scholar
Wilson, DS & Tappel, ALBinding of plasma selenoprotein P to cell membranes. J Inorg Biochem (1993) 51, 707–714.CrossRefGoogle ScholarPubMed
Wingerath, T, Sies, H & Stahl, WXanthophyll esters in human skin. Arch Biochem Biophys (1998) 355, 271–274.CrossRefGoogle ScholarPubMed
Wolffram, SMechanisms of intestinal absorption of selenium. Med Klein (Munich) (1995) 90, Suppl., 1–5.Google ScholarPubMed
Wu, K, Schwartz, SJ, Platz, EA, Clinton, SK, Erdman, JW Jr, Ferruzzi, MG, Willett, WC & Giovannucci, ELVariations in plasma lycopene and specific isomers over time in a cohort of US men. J Nutr (2003) 133, 1930–1936.CrossRefGoogle Scholar
Zhao, J & Agarwal, RTissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention. Carcinogenesis (1999) 20, 2101–2108.CrossRefGoogle ScholarPubMed