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Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep

Published online by Cambridge University Press:  09 March 2007

Margaret Gill ,
J. H. M. Thornley ,
J. L. Black ,
J. D. Oldham  and
D. E. Beever
Margaret Gill
Affiliation:
Grassland Research Institute, Hurley, Maidenhead, Berks SL6 5LR
J. H. M. Thornley
Affiliation:
Grassland Research Institute, Hurley, Maidenhead, Berks SL6 5LR
J. L. Black
Affiliation:
CSIR0, Division of Animal Physiology, Ian Clunies Ross Animal Research Laboratory, Prospect, PO Box 239, Blacktown, New South Wales 2148, Australia
J. D. Oldham
Affiliation:
National Institute for Research in Dairying, Shinjield, Reading, Berks RG2 9AT
D. E. Beever
Affiliation:
Grassland Research Institute, Hurley, Maidenhead, Berks SL6 5LR
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Abstract

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1. A mathematical model is described, which simulates the metabolism of absorbed nutrients (amino acids, acetic acid, butyric acid, glucose, lipid and propionic acid) in growing sheep.

2. The basic assumption of the model is that each nutrient is partitioned between synthetic, oxidative or intermediate reactions with rates of reaction which are described using enzyme kinetics. These rates depend on the relationship between maximum reaction rates, constants of affinity and inhibition and the concentrations of metabolites as determined by the model.

3. Synthetic reactions calculate fat and protein deposition while intermediate reactions involve the production of ATP and NADPH. There is a total of twelve state variables and the model, programmed in CSMP and ACSL, is solved by integration of twelve differential equations.

4. The model calculates the efficiency of utilization of metabolizable energy for different nutrient inputs and the results may be interpreted in terns of fluxes through the metabolite pools. Simulations using inputs representing forage- and concentrate-based diets indicated decreased efficiency for the forage at high levels of intake and possible reasons for this were further studied in simulations where the inputs of protein and glucose were varied.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 3 , November 1984 , pp. 621 - 649
Copyright
Copyright © The Nutrition Society 1984

References

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