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Serum proteinase inhibitors and other serum proteins in protein-energy malnutrition

Published online by Cambridge University Press:  24 October 2018

F. P. Schelp ,
P. Migasena ,
Praneet Pongpaew ,
W. H. P. Schreurs  and
Venus Supawan
F. P. Schelp
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand
P. Migasena
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand
Praneet Pongpaew
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand
W. H. P. Schreurs
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand
Venus Supawan
Affiliation:
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand
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Abstract

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  1. 1. The concentrations of serum protein albumin, prealbumin and transferrin were determined in twentyeight cases of protein-energy malnutrition (PEM) with infection, together with the levels of serum proteinase inhibitors (PI), α1-antitrypsin (AT), α1-antichymotrypsin (Ach), α2-macroglobulin (α2M) and inter-α-trypsin inhibitor (IαI).

  2. 2. Albumin, prealbumin and transferrin concentrations, as well as the levels of PI, IαI and α2M were found to be lower in cases of PEM associated with infection than the corresponding values for a group of healthy Thai preschool children and a group of newborn Thai children, but despite starvation AT and Ach values generally were increased.

  3. 3. The results provide support for the hypothesis that PI, especially AT and Ach might limit the synthesis of albumin, prealbumin and transferrin in PEM associated with infection, via the inhibition of the mobilization of body's own protein.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 38 , Issue 1 , July 1977 , pp. 31 - 38
Copyright
Copyright © The Nutrition Society 1977

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