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Serum phospholipid fatty acid profile and dietary intake in an adult Mediterranean population with cystic fibrosis

Published online by Cambridge University Press:  08 March 2007

Gabriel Olveira ,
Antonio Dorado ,
Casilda Olveira ,
Alicia Padilla ,
Gemma Rojo-Martínez ,
Eva García-Escobar ,
Inmaculada Gaspar ,
Montserrat Gonzalo  and
Federico Soriguer
Gabriel Olveira*
Affiliation:
Endocrinology and Nutrition Service, 4a planta, Pabellón A, Carlos Haya University Hospital, Avenida Carlos Haya, Malaga 29010, Spain
Antonio Dorado
Affiliation:
Pneumology Service, Carlos Haya University Hospital, Malaga, Spain
Casilda Olveira
Affiliation:
Pneumology Service, Carlos Haya University Hospital, Malaga, Spain
Alicia Padilla
Affiliation:
Pneumology Service, Carlos Haya University Hospital, Malaga, Spain
Gemma Rojo-Martínez
Affiliation:
Endocrinology and Nutrition Service, 4a planta, Pabellón A, Carlos Haya University Hospital, Avenida Carlos Haya, Malaga 29010, Spain
Eva García-Escobar
Affiliation:
Endocrinology and Nutrition Service, 4a planta, Pabellón A, Carlos Haya University Hospital, Avenida Carlos Haya, Malaga 29010, Spain
Inmaculada Gaspar
Affiliation:
Pneumology Service, Carlos Haya University Hospital, Malaga, Spain
Montserrat Gonzalo
Affiliation:
Endocrinology and Nutrition Service, 4a planta, Pabellón A, Carlos Haya University Hospital, Avenida Carlos Haya, Malaga 29010, Spain
Federico Soriguer
Affiliation:
Endocrinology and Nutrition Service, 4a planta, Pabellón A, Carlos Haya University Hospital, Avenida Carlos Haya, Malaga 29010, Spain
*
*Corresponding author: Dr Gabriel Olveira-Fuster, fax +34 952 28 67 04, email [email protected]
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Abstract

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The relative importance of the usual diet in serum phospholipids in subjects with cystic fibrosis (CF) has been poorly studied. To compare the fatty acid profile in serum phospholipids from adult CF subjects with that of healthy subjects, and determine the role of the normal diet in this profile, we studied thirty-seven adult CF subjects with stable pulmonary disease and thirty-seven healthy controls matched for age, sex and nutritional status. A dietary questionnaire was obtained, anthropometric data were recorded, and the fatty acid profile measured by GLC. Compared with the controls, the percentages of myristic, palmitoleic and stearic acids and total MUFA were significantly higher in the CF group, and DHA, linoleic acid, total PUFA and n−6 fatty acids were significantly lower in the CF group. The CF subjects with worse pulmonary function and with pancreatic insufficiency had significantly lower levels of linoleic and n−6 fatty acids. The total energy intake was significantly higher in the CF subjects, although the energy distribution in the CF subjects and the controls was not different for the carbohydrates, lipids and proteins. No differences were detected in fat intake for MUFA (51 (sd 4) v. 52 (sd 4) %) or saturated fatty acids (33·5 (sd 5) v. 31·2 (sd 3·8) %), but the PUFA were slightly lower in the CF subjects (15·4 (sd 4·5) v. 17·4 (sd 4·2) %; P=0·02). The usual dietary intake of fatty acids by adult CF subjects does not appear to explain the difference in the fatty acid profile compared with controls. This suggests an abnormal fatty acid metabolism in CF subjects.

Keywords

Cystic fibrosisSerum phospholipid fatty acidsDiet
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 2 , August 2006 , pp. 343 - 349
Copyright
Copyright © The Nutrition Society 2006

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