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Selenium status in patients with liver cirrhosis and alcoholism

Published online by Cambridge University Press:  09 March 2007

U. Johansson ,
F. Johnsson ,
B. Joelsson ,
M. Berglund  and
B. Åkesson
U. Johansson
Affiliation:
Department of Clinical ChemistryUniversity Hospital, S-221 85 Lund, Sweden
F. Johnsson
Affiliation:
Department of SurgeryUniversity Hospital, S-221 85 Lund, Sweden
B. Joelsson
Affiliation:
Department of SurgeryUniversity Hospital, S-221 85 Lund, Sweden
M. Berglund
Affiliation:
Department of Psychiatry, University Hospital, S-221 85 Lund, Sweden
B. Åkesson
Affiliation:
Department of Clinical ChemistryUniversity Hospital, S-221 85 Lund, Sweden
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Abstract

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1. Selenium status and blood levels of other nutrients related to lipid peroxidation were studied in patients with advanced alcoholic liver cirrhosis, in male alcoholics who had been abstinent for at least 1 month and in healthy control subjects.

2. Plasma Se was decreased in alcoholic cirrhosis but not among alcoholics in abstinence. Platelet glutathione peroxidase (EC 1. 11. 1.9; GSH-Px) activity was decreased in cirrhotic patients, whereas GSH-Px in blood and plasma was the same as in controls for both groups of patients.

3. Plasma retinol and plasma α-tocopherol were decreased in alcoholic cirrhosis, whereas plasma ascorbic acid was the same in all groups.

4. The decreases in platelet GSH-Px, plasma Se and α-tocopherol indicate a deranged antioxidant defence in patients with advanced alcoholic cirrhosis, but the levels of these and other nutrients were generally not correlated to common clinical chemical indicators of liver disease.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 2 , March 1986 , pp. 227 - 233
Copyright
Copyright © The Nutrition Society 1986

References

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