Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-22T23:13:20.840Z Has data issue: false hasContentIssue false
  • English
  • Français

Selenium status in patients with liver cirrhosis and alcoholism

Published online by Cambridge University Press:  09 March 2007

U. Johansson ,
F. Johnsson ,
B. Joelsson ,
M. Berglund  and
B. Åkesson
U. Johansson
Affiliation:
Department of Clinical ChemistryUniversity Hospital, S-221 85 Lund, Sweden
F. Johnsson
Affiliation:
Department of SurgeryUniversity Hospital, S-221 85 Lund, Sweden
B. Joelsson
Affiliation:
Department of SurgeryUniversity Hospital, S-221 85 Lund, Sweden
M. Berglund
Affiliation:
Department of Psychiatry, University Hospital, S-221 85 Lund, Sweden
B. Åkesson
Affiliation:
Department of Clinical ChemistryUniversity Hospital, S-221 85 Lund, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Selenium status and blood levels of other nutrients related to lipid peroxidation were studied in patients with advanced alcoholic liver cirrhosis, in male alcoholics who had been abstinent for at least 1 month and in healthy control subjects.

2. Plasma Se was decreased in alcoholic cirrhosis but not among alcoholics in abstinence. Platelet glutathione peroxidase (EC 1. 11. 1.9; GSH-Px) activity was decreased in cirrhotic patients, whereas GSH-Px in blood and plasma was the same as in controls for both groups of patients.

3. Plasma retinol and plasma α-tocopherol were decreased in alcoholic cirrhosis, whereas plasma ascorbic acid was the same in all groups.

4. The decreases in platelet GSH-Px, plasma Se and α-tocopherol indicate a deranged antioxidant defence in patients with advanced alcoholic cirrhosis, but the levels of these and other nutrients were generally not correlated to common clinical chemical indicators of liver disease.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 55 , Issue 2 , March 1986 , pp. 227 - 233
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Aaseth, J., Alexander, J., Thomassen, Y., Blomhoff, J. P. & Skrede, S. (1982). Clinical Biochemistry 15, 281–283.CrossRefGoogle Scholar
Åkesson, B. & Öckerman, P. A. (1985). British Journal of Nutrition 53, 199–205.CrossRefGoogle Scholar
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. Washington DC: APA.Google Scholar
Beattie, A. D. & Sherlock, S. (1976). Gut 17 571–575.CrossRefGoogle Scholar
Beilstein, M. A. & Whanger, P. D. (1983). Journal of Nutririon 113, 2138–2146.CrossRefGoogle Scholar
Bonjour, J. P. (1979). International Journal for Vitamin and Nutrition Research 49, 434–441.Google Scholar
Bonjour, J. P. (1981 a). International Journal for Vitamin and Nutrition Research 51, 307–318.Google Scholar
Bonjour, J. P. (1981 b). International Journal for Vitamin and Nutrition Research 51, 166–177.Google Scholar
Bryant, R. W., Simon, T. C. & Bailey, J. M. (1983). Journal of Biological Chemistry 257, 14937–14943.CrossRefGoogle Scholar
Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (1974). Scandinavian Journal of Clinical and Laboratory Investigation 33, 291–306.CrossRefGoogle Scholar
Comporti, M. (1978). In Biochemical Mechanisms of Liver Injury, pp. 469–516 [Slater, T.F., editor]. London: Academic Press.Google Scholar
Comporti, M., Benedetti, A. & Chieli, E. (1973). Lipids 8, 498–502.CrossRefGoogle ScholarPubMed
DeLeenheer, A. P., DeBevere, V. O. R. C., DeRuyter, M. G. M. & Claeys, A. E. (1979) Journal of Chromatography 162, 408–413.CrossRefGoogle Scholar
Devgun, M. S., Fiabane., A., Paterson, C. R., Zarembski, P. & Guthrie, A. (1981). British Journal of Nutrition 45, 469–473.CrossRefGoogle Scholar
Dutta, S. K., Miller, P. A., Greenberg, L. B. & Levander, O. A. (1983). American Journal of Clinica1 Nutrition 38, 713–718.CrossRefGoogle Scholar
Günzler, W. A., Kremers, H. & Flohé, L. (1974). Zeitschrft für Klinische Chemie und Klinische Biochemie 12, 444–448.Google Scholar
Laurell, C.-B. (1972). Scandinavian Journal of Clinical and Laboratory Investigation 29, Suppl. 124, 21–37.CrossRefGoogle Scholar
Levander, O.A., Alfthan, G., Arvilommi, H., Gref, C. G., Huttunen, J. K., Kataja, M., Koivistoinen, P. & Pikkarainen, J. (1983 a). American Journal of Clinical Nutrition 37, 887–897.CrossRefGoogle Scholar
Levander, O. A., DeLoach, D. P., Morris, V. C. & Moser, P. B. (1983 b). Journal of Nutrition 113, 55–63.CrossRefGoogle Scholar
Lowry, O.H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Journal of Biological Chemistry 193, 265–275.CrossRefGoogle Scholar
Marklund, S. L., Westman, N. G., Lundgren, E. & Roos, G. (1982). Cancer Research 42, 1955–1961.Google Scholar
Motsenbecker, M. A. & Tappel, A. L. (1982). Biochimica et Biophysica Acta 704, 253–260.CrossRefGoogle Scholar
Okamura, M. (1980). Clinica Chimica Acta 103, 259–268.Google Scholar
Reynolds, E. S. & Moslen, M. T. (1980). In Free Radicals in Biology vol. IV, pp. 49–94 [Pryor, W. A., editor]. London: Academic Press.CrossRefGoogle Scholar
Rose, H. G. & Oklander, M. (1965). Journal of Lipid Research 6, 428–431.CrossRefGoogle Scholar
Shaw, S., Jayatilleke, E., Ross, W. A., Gordon, E. R. & Lieber, C. S. (1981). Journal of Laboratory and Clinical Medicine 98, 417–424.Google Scholar
Simonsson, P., Nilsson, Å., & Åkesson, B. (1982). American Journal of Clinical Nutrition 35, 36–41.CrossRefGoogle Scholar
Välimäki., M. J., Harju, K. J. & Ylikahri, R. H. (1983). Clinica Chimica Acta 130, 291–296.CrossRefGoogle Scholar
Van waes, L. & Lieber, C. S. (1980). In Toxic Injury of the Liver, pp. 629–653 [Farber, E. and Fisher, M. M., editors]. New York: Marcel Dekker.Google Scholar
Wang, Y. X., Böcker, K., Reuter, H., Kiem, J., Kasperek, K., Iyengar, G. V., Loogen, F., Gross, R. & Feinendegen, L. E. (1981). Klinische Wochenschrift 591, 817–818.CrossRefGoogle Scholar
Yagi, K. (1976). Biochemical Medicine 15, 212–216.CrossRefGoogle Scholar