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Selenium (selenate) transport by human placental brush border membrane vesicles

Published online by Cambridge University Press:  09 March 2007

D. B. Shennan
D. B. Shennan
Affiliation:
Department of Human Anatomy, University of Oxford, South Parks Road, Oxford OX1 3QX
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Abstract

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1. Selenate uptake by human placental brush-border-membrane vesicles was studied in order to establish whether this anion shares a pathway with sulphate.

2. Selenate uptake was found to be saturable with respect to medium selenate and was inhibited by the anion exchange inhibitor 4,4′-diisothiocyano-stilbene-2,2′-disulphonate (DIDS).

3. Anions which have a similar tetrahedral shape to selenate, e.g. chromate, molybdate, tungstate and sulphate, were effective inhibitors of selenate uptake when added to the incubation medium.

4. Sulphate inhibited selenate influx in a dose-dependent fashion; moreover sulphate was found to be a competitive inhibitor of selenate uptake.

5. It is concluded that selenate and sulphate share a pathway for transport in the human placental microvillus membrane.

Type
Clinical and Human Nutrition papers: Studies in Man
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 13 - 19
Copyright
Copyright © The Nutrition Society 1988

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