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Riboflavin deficiency in the rat: effects on iron utilization and loss

Published online by Cambridge University Press:  09 March 2007

Hilary J. Powers ,
L. T. Weaver ,
S. Austin ,
A. J. A. Wright  and
Susan J. Fairweather-Tait
Hilary J. Powers
Affiliation:
MRC Dunn Nutrition Unit, Milton Road, Cambridge CB4 IXJ
L. T. Weaver
Affiliation:
MRC Dunn Nutrition Unit, Milton Road, Cambridge CB4 IXJ
S. Austin
Affiliation:
MRC Dunn Nutrition Unit, Milton Road, Cambridge CB4 IXJ
A. J. A. Wright
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
Susan J. Fairweather-Tait
Affiliation:
AFRC Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich NR4 7UA
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Abstract

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Iron absorption and daily loss of Fe were measured in riboflavin-deficient (B2-) Norwegian hooded rats and controls (B2+). Animals were fed on a test meal extrinsically labelled with 59Fe and whole-body radioactivity measured for 15 d. Riboflavin deficiency led to a reduction in the percentage of the 59Fe dose absorbed and an increased rate of 59Fe loss. All post-absorption 59Fe loss could be accounted for by faecal 59Fe, confirming that the loss was gastrointestinal. Fe concentrations and 59Fe as a percentage of retained whole-body 59Fe were higher in the small intestine of riboflavin-deficient animals than their controls, 14 d after the test meal. A separate experiment demonstrated that riboflavin deficiency was associated with a significant proliferative response of the duodenal crypts of the small intestine. These observations may explain the enhanced Fe loss in riboflavin deficiency.

Keywords

IronCrypt cell proliferationRat
Type
Effects of Altered Vitamin Status
Information
British Journal of Nutrition , Volume 65 , Issue 3 , May 1991 , pp. 487 - 496
Copyright
Copyright © The Nutrition Society 1991

References

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