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Retinoid metabolism in human leucocytes

Published online by Cambridge University Press:  09 March 2007

D. Sklan ,
S. Trifon ,
O. Kedar ,
N. Vaisman  and
Y. Berner
D. Sklan
Affiliation:
Faculty of Agriculture, Hebrew University, Rehovot 76100, Israel
S. Trifon
Affiliation:
Faculty of Agriculture, Hebrew University, Rehovot 76100, Israel
O. Kedar
Affiliation:
Faculty of Agriculture, Hebrew University, Rehovot 76100, Israel
N. Vaisman
Affiliation:
Pediatric Division B,Kaplan Hospital, Rehovot 76100, Israel
Y. Berner
Affiliation:
Harizfeld Geriatric Division, Kaplan Hospital, Rehovot 76100, Israel
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Abstract

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Leucocytes from subjects from 0 to 80 years old were separated into mononuclear and granulocyte fractions and the retinoids and retinoid-binding fractions were examined. Both leucocyte ractions were found to contain retinol, retinoic acid and an additional retinoid; retinoic acid Comprised 40% of retinoids in some samples. The protein fractions containing retinoids included a 200 k Da protein and several 14–18 k Da proteins. Plasma concentrations of retinol changed little with increasing age. In contrast, leucocyte concentrations of retinoids and retinoid-binding proteins increased quadratically with age. However, in granulocytes from young children retinoids were almost undetectable.

Keywords

Retinoid metabolismLeucocytesHuman
Type
Retinoid metabolism in lecucocytes
Information
British Journal of Nutrition , Volume 73 , Issue 6 , June 1995 , pp. 889 - 895
Copyright
Copyright © The Nutrition Society 1995

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