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Response of circulating leptin to Ramadan daytime fasting: a circadian study

Published online by Cambridge University Press:  08 March 2007

André Bogdan ,
Belal Bouchareb  and
Yvan Touitou
André Bogdan
Affiliation:
Laboratoire de Biochimie, Faculté de Médecine Pitié-Salpétrière 91 boulevard de l'hôpital, 75 013, Paris, France
Belal Bouchareb
Affiliation:
Laboratoire d'hormonologie, Hôpital Militaire Universitaire Oran, Algeria
Yvan Touitou*
Affiliation:
Laboratoire de Biochimie, Faculté de Médecine Pitié-Salpétrière 91 boulevard de l'hôpital, 75 013, Paris, France
*
*Corresponding author: Professor Yvan Touitou, fax +3 1 40 77 96 65, email [email protected]
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Abstract

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Although the effects of short-term fasting on serum leptin concentrations are known, those resulting from long-lasting modifications of food intake schedule, as during the month of Ramadan, have not yet been extensively studied. Therefore, serum concentrations of leptin were measured around the clock at 4-hourly intervals before the beginning of Ramadan and on the twenty-third day of Ramadan daytime fasting in ten male subjects keeping the same usual activity pattern and general synchronisation in both situations. Time series were analysed with repeated measures ANOVA and Cosinor. No significant changes in amplitude or 24 h mean concentration were seen, but significant shifts of 5 h 30 min in peak and trough serum leptin levels were found on the twenty-third day of Ramadan.

Keywords

RhythmsLeptinFastingRamadan
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 4 , April 2005 , pp. 515 - 518
Copyright
Copyright © The Nutrition Society 2005

References

Aadil-Benchekroun, N (1993) Influence du jeûne du Ramadan sur la pharmacocinétique de la théophylline et le cycle du cortisol (Influence of Ramadan fasting on the pharmacokinetic of theophylline and on the cycle of cortisol). Doctoral thesis, Université Claude Bernard, Lyon, France.Google Scholar
Al-Hadramy, MS, Zawawi, TH & Abdelwahab, SM (1987) Altered cortisol levels in relation to Ramadan. Eur J Clin Nutr 42, 359–362.Google Scholar
Apfelbaum, M, Reinberg, A, Nillus, P & Halberg, F (1969) Rythmes circadiens de l'alternance veille/sommeil pendant l'isolement. Presse Méd 77, 879–882.Google Scholar
Bensouda, JD, Ouazzani, W, Lachkar, A, Harniani, A & Belkhadir, J (1982) Variations du cycle du cortisol sous l'influence du jeûne au cours du mois de Ramadan. Symposium International 22–23 Octobre 1991, Rabat-Maroc. In Bases Actuelles de l'Exploration Hormonale p. 82. Paris, France: SEPE/FRH.Google Scholar
Boden, G, Chen, X, Mozzoli, M & Ryan, I (1996) Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81, 3419–3423.Google ScholarPubMed
Bogdan, A, Bouchareb, B & Touitou, Y (2001) Ramadan alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans? Life Sci 68, 1607–1615.CrossRefGoogle ScholarPubMed
Dallongeville, J, Hecquet, B, Lebel, P, Edmé, J-L, Le Fur, C, Fruchart, J-C, Auwerx, J & Romon, M (1998) Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle. Int J Obes 22, 728–733.CrossRefGoogle ScholarPubMed
Eliman, A & Marcus, C (2002) Meal timing, fasting and glucocorticoids interplay in serum leptin concentrations and diurnal profile. Eur J Endocrinol 147, 181–188.CrossRefGoogle Scholar
Halberg, F (1974) Protection by timing treatment according to bodily rhythms. An analogy to protection by scrubbing before surgery. Chronobiologia 1 Suppl. 1. 27–72.Google ScholarPubMed
Haouari-Ourerro, F, Haouari, M, Aouidet, A, Sfaxi, A, Hedhili, A & Nagati, K (1994) Ramadan et rythmes circadiens des taux sériques de la bilirubine des enzymes hépatiques et des oligo-élements (Mg 2+, Cu 2+, Zn 2+ ). Ramadan and circadian rhythms of the serum concentrations of bilirubine, hepatic enzymes and oligo-elements. In Proc. of l er Congrès International Ramadan et Santé, Casablanca, Maroc (abstract).Google Scholar
Harvey, J & Ashford, MLJ (2003) Leptin in the CNS: much more than a satiety signal. Neuropharmacology 44, 845–854.CrossRefGoogle ScholarPubMed
Iraki, L, Abkari, A, Vallot, T, Amrani, N, Khlifa, RH, Jellouli, K & Hakkou, F (1997a) Effet du jeûne du Ramadan sur le pH intragastrique enregistré sur 24 heures chez le sujet sain. Effect of Ramadan fasting on the intragastric pH recorded 24 hours in healthy subjects. Gastroentérol Clin Biol 21, 813–819.Google Scholar
Iraki, L, Bogdan, A, Hakkou, F, Abkari, A & Touitou, Y (1997b) Ramadan diet restrictions modify the circadian time structure in humans. A study on plasma gastrin, insulin, glucose and calcium and on gastric pH. J Clin Endocrinol Metab 82, 1261–1273.Google Scholar
Kawasaki, T, Ueno, M, Uezono, K, Matsuoka, M, Omae, T, Halberg, F, Wendt, H, Taggett-Anderson, MA & Haus, E (1980) Differences and similarities among circadian characteristics of plasma renin activity in healthy young women in Japan and the United States. Am J Med 68, 91–96.CrossRefGoogle ScholarPubMed
Leung, SY, Ng, TH, Yuen, ST, Lauder, IJ & Ho, FC (1993) Patterns of cerebral atherosclerosis in Hong Kong Chinese. Severity in intracranial and extracranial vessels. Stroke 24, 779–786.CrossRefGoogle Scholar
Nelson, W, Scheving, LE & Halberg, F (1975) Circadian rhythms in mice fed a single daily meal and different stages of lighting regimen. J Nutr 105, 171–184.CrossRefGoogle ScholarPubMed
Nicklas, BJ, Toth, MJ, Goldberg, AP & Poehlman, ET (1997) Racial differences in plasma leptin concentrations in obese postmenopausal women. J Clin Endocrinol Metab 82, 315–317.Google ScholarPubMed
Reinberg, A (1991) Chronobiologie et Chronothérapeutique; Heure Optimale d'Administration des Médicaments. Paris: Flammarion Médecine-Sciences.Google Scholar
Saad, MF, Riad-Gabriel, MG, Khan, A, Sharma, A, Michael, R, Jinagouda, SJ, Boyadjian, R & Steil, GM (1998) Diurnal and ultradian rhythmicity of plasma leptin: effect of gender and adiposity. J Clin Endocrinol Metab 83, 453–459.Google ScholarPubMed
Schoeller, DA, Cella, LK, Sinha, MK & Caro, JF (1997) Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 100, 1882–1887.CrossRefGoogle ScholarPubMed
Simon, C, Gronfier, C, Schlienger, JL & Brandenberger, G (1998) Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocrinol Metab 83, 1893–1899.CrossRefGoogle ScholarPubMed
Sinha, MK, Ohannesian, JP, Heiman, ML, Kriauciunas, A, Stephens, TW, Magosin, S, Marco, C & Caro, JF (1996) Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97, 1344–1347.CrossRefGoogle ScholarPubMed
Touitou, Y & Haus, E (1994) Biologic Rhythms in Clinical and Laboratory Medicine. Berlin: Springer Verlag.Google Scholar
Touitou, Y, Portaluppi, F, Smolensky, M & Rensing, L (2004) Ethical principles and standards for the conduct of human and animal biological rhythm research. Chronobiol Int 21, 161–170.CrossRefGoogle ScholarPubMed
Wetterberg, L, Halberg, F, Halberg, E, Haus, E, Kawasaki, T, Ueno, M, Uezono, K, Cornelissen, G, Matsuoka, M & Omae, T (1986) Circadian characteristics of urinary melatonin from clinically healthy young women at different civilization disease risks. Acta Med Scand 220, 1–81.CrossRefGoogle ScholarPubMed
Wetterberg, L, Halberg, F, Tarquini, B, et al. (1979) Circadian variation in urinary melatonin in clinically healthy women in Japan and the United States of America. Experientia 35, 416–419.CrossRefGoogle ScholarPubMed
Woo, J, Ho, SC, Donnan, S & Swaminathan, R (1988) Nutritional correlates of blood pressure in elderly Chinese. J Hum Hypertens 1, 287–291.Google ScholarPubMed
Woo, J, Swaminathan, R, Pang, CR, MacDonald, D, Mak, YT, Ho, SC & Lau, E (1989) Some biochemical indices of bone turnover in elderly Chinese. J Med 20, 229–239.Google ScholarPubMed
Zhang, Y, Proenca, R, Maffei, M, Barone, M, Leopold, L & Friedman, JM (1994) Positional cloning of the mouse obese gene and its homologue. Nature 372, 425–432.CrossRefGoogle ScholarPubMed
Zhao, ZY, Fu, YR, Li, XH, Li, YY, Bogdan, A & Touitou, Y (2002a) Age-related modifications of circadian rhythm of serum leptin in healthy men. Gerontology 48, 309–314.CrossRefGoogle ScholarPubMed
Zhao, ZY, Xie, Y, Fu, YR, Bogdan, A & Touitou, Y (2002b) Aging and the circadian rhythm of melatonin: a cross-sectional study of Chinese subjects 30–110 yr of age. Chronobiol Int 19, 1171–1182.CrossRefGoogle ScholarPubMed
Zhao, ZY, Xie, Y, Fu, YR, Bogdan, A & Touitou, Y (2003a) Circadian rhythm characteristics of serum cortisol and dehydroepiandrosterone sulfate in healthy Chinese men aged 30 to 60 years. A cross-sectional study. Steroids 68, 133–138.CrossRefGoogle ScholarPubMed
Zhao, ZY, Xie, Y, Fu, YR, Bogdan, A & Touitou, Y (2003b) Cortisol secretion in the elderly. Influence of age, sex and cardiovascular disease in a Chinese population. Steroids 68, 551–555.CrossRefGoogle ScholarPubMed
Zigmond, MJ, Shoemaker, WJ, Larin, F & Wurtman, RJ (1969) Hepatic tyrosine transaminase rhythm: interaction of environmental lighting, food consumption and dietary protein content. J Nutr 98, 71–75.CrossRefGoogle ScholarPubMed