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Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy

Published online by Cambridge University Press:  09 March 2007

Tsunenobu Tamura ,
Robert L. Goldenberg ,
Kelley E. Johnston  and
Victoria R. Chapman
Tsunenobu Tamura*
Affiliation:
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham AL, USA
Robert L. Goldenberg
Affiliation:
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham AL, USA
Kelley E. Johnston
Affiliation:
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham AL, USA
Victoria R. Chapman
Affiliation:
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham AL, USA
*
*Corresponding author: Professor T. Tamura, fax +1205 934 7049, email [email protected]
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Abstract

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We previously reported that pregnant women whose plasma Zn concentrations were below the 50th percentile tended to have high pre-pregnancy BMI (kg/m2) values. We therefore hypothesized that in pregnant women, plasma Zn concentrations are negatively correlated with BMI. We evaluated the association between BMI values and plasma Zn concentrations in 1474 women whose blood samples were obtained before 15 weeks of gestation. Their mean age was 22·7 years and mean gestational age at blood sampling was 10 weeks. The mean plasma Zn concentration and BMI were 11·6 μmol/l and 26·6 kg/m2 respectively. Because plasma Zn concentrations decrease as gestational age increases, plasma Zn concentrations were standardized by Z-scores. Z-score distributions were compared among the quartiles of BMI. The highest BMI group had the lowest plasma Zn concentrations, whereas the lowest BMI group had the highest; the differences were significant between the BMI groups (P<0·0001). The interpretation of plasma Zn concentrations to assess Zn nutriture in pregnancy may be complicated not only by the well-established factor of gestational age at blood sampling, but also by a previously unrecognized factor, maternal BMI.

Keywords

Plasma zincBody mass indexPregnant women
Type
Research Article
Information
British Journal of Nutrition , Volume 91 , Issue 5 , May 2004 , pp. 773 - 777
Copyright
Copyright © The Nutrition Society 2004

References

Atkinson, RL, Dahms, WT, Bray, GA, Jacob, R & Sandstead, HH (1978) Plasma zinc and copper in obesity and after intestinal bypass. Ann Int Med 89, 491–493.CrossRefGoogle ScholarPubMed
Begin-Heick, N, Dalpe-Scott, M, Rowe, J & Heick, HMC (1985) Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mice. Diabetes 34, 179–184.CrossRefGoogle Scholar
Campbell, DM & MacGillivray, I (1984) The importance of plasma volume expansion and nutrition in twin pregnancy. Acta Genet Med Gemellol 33, 19–24.Google ScholarPubMed
Chandra, RK & Kutty, KM (1980) Immunocompetence in obesity. Acta Paediatr Scand 69, 25–30.CrossRefGoogle ScholarPubMed
Chen, M-D, Lin, P-Y, Lin, W-H & Cheng, V (1988) Zinc in hair and serum of obese individuals in Taiwan. Am J Clin Nutr 48, 1307–1309.CrossRefGoogle ScholarPubMed
Cnattingius, S, Bergström, R, Lipworth, L & Kramer, MS (1998) Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med 338, 147–152.CrossRefGoogle ScholarPubMed
Collipp, PJ (1984) New developments in medical therapy of obesity. Pediatr Ann 13, 465–472.Google ScholarPubMed
Di Martino, G, Matera, MG, De Martino, B, Vacca, C, Di Martino, S & Rossi, F (1993) Relationship between zinc and obesity. J Med 24, 177–183.Google ScholarPubMed
Donaldson, DL, Smith, CC & Koh, E (1987) Effects of obesity and diabetes on tissue zinc and copper concentrations in the Zucker rat. Nutr Res 7, 393–399.CrossRefGoogle Scholar
Giroux, EL (1975) Determination of zinc distribution between albumin and α2 -macroglobulin in human serum. Biochem Med 12, 258–266.CrossRefGoogle Scholar
Goldenberg, RL, Tamura, T, Cliver, SP, Cutter, GR, Hoffman, HJ & Davis, RO (1991) Maternal serum alpha2-macroglobulin and fetal growth retardation. Obstet Gynecol 78, 594–599.Google Scholar
Goldenberg, RL, Tamura, T, Neggers, Y, Copper, RL, Johnston, KE, DuBard, MB & Hauth, JC (1995) The effect of zinc supplementation on pregnancy outcome. J Am Med Assoc 274, 463–468.CrossRefGoogle ScholarPubMed
Hambidge, KM & Droegemueller, W (1974) Changes in plasma and hair concentrations of zinc, copper, chromium, and manganese during pregnancy. Obstet Gynecol 44, 666–672.Google Scholar
Hashim, Z, Woodhouse, L & King, JC (1996) Interindividual variation in circulating zinc concentrations among healthy adult men and women. Int J Food Sci Nutr 47, 383–390.CrossRefGoogle ScholarPubMed
Kennedy, ML & Failla, ML (1986) Influence of genetic obesity on tissue concentrations of zinc, copper, manganese and iron in mice. J Nutr 116, 1432–1441.CrossRefGoogle ScholarPubMed
Kennedy, ML & Failla, ML (1987) Zinc metabolism in genetically obese (ob/ob) mice. J Nutr 117, 886–893.CrossRefGoogle ScholarPubMed
Lowy, SL, Fisler, JS, Drenick, EJ, Hunt, IF & Swendseid, ME (1986) Zinc and copper nutriture in obese men receiving very low calorie diets of soy or collagen protein. Am J Clin Nutr 43, 272–287.CrossRefGoogle ScholarPubMed
Maher, JE III, Goldenberg, RL, Tamura, T, Cliver, SP, Johnston, KE & Hoffman, HJ (1993) Indicators of maternal nutritional status and birth weight in term deliveries. Obstet Gynecol 81, 165–169.Google ScholarPubMed
Mardones-Santander, F, Rosso, P, Stekel, A, Ahumada, E, Llaguno, S, Pizarro, F, Salinas, J, Vial, I & Walter, T (1988) Effect of a milk-based food supplement on maternal nutritional status and fetal growth in underweight Chilean women. Am J Clin Nutr 47, 413–419.CrossRefGoogle ScholarPubMed
Marotta, A, Todisco, N, Di Toro, A, Toraldo, R, Ponte, G & Perrone, L (1995) Zinc content of lymphocytes in obese children. Nutr Res 15, 1411–1415.CrossRefGoogle Scholar
Marreiro, DDN, Fisberg, M & Cozzolino, SMF (2002) Zinc nutritional status in obese children and adolescents. Biol Trace Elem Res 86, 107–122.Google ScholarPubMed
Pearson, TC, Guthrie, DL, Simpson, J, Chinn, S, Barosi, G, Ferrant, A, Lewis, SM & Najean, Y (1995) Interpretation of measured red cell mass and plasma volume in adults: expert panel on radionuclides of the International Council for Standardization in Haematology. Br J Haematol 89, 748–756.CrossRefGoogle Scholar
Serfass, RE, McHugh, MZ, Struempler, BJ & Garcia, PA (1983) Elemental balance in obese women fed a hypocaloric dietary regimen. Nutr Res 3, 157–170.CrossRefGoogle Scholar
Tamura, T & Goldenberg, RL (1996) Zinc nutriture and pregnancy outcome. Nutr Res 16, 139–181.CrossRefGoogle Scholar
Tamura, T, Goldenberg, RL, Johnston, KE & DuBard, M (2000) Maternal plasma zinc concentrations and pregnancy outcome. Am J Clin Nutr 71, 109–113.CrossRefGoogle ScholarPubMed
Tamura, T, Johnston, KE, Freeberg, LE, Perkins, LL & Goldenberg, RL (1994) Refrigeration of blood samples prior to separation is essential for the accurate determination of plasma or serum zinc concentrations. Biol Trace Elem Res 41, 165–173.CrossRefGoogle ScholarPubMed
Tanaka, S, Inoue, S, Isoda, F, Waseda, M, Ishihara, M, Yamakawa, T, Sugiyama, A, Takamura, Y & Okuda, K (1993) Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes 17, 631–636.Google ScholarPubMed
Tungtrongchitr, R, Pongpaew, P, Vudhivai, N, Changbumrung, S, Tungtrongchitr, A, Phonrat, B, Viroonudomphol, D, Pooudong, S & Schelp, FP (2003) Relationship between alpha-2-macroglobulin, anthropometric parameters and lipid profiles in Thai overweight and obese in Bangkok. Nutr Res 23, 1143–1152.CrossRefGoogle Scholar
Tuttle, S, Aggett, PJ, Campbell, D & MacGillivray, I (1985) Zinc and copper nutrition in human pregnancy: a longitudinal study in normal primigravidae and in primigravidae at risk of delivering a growth retarded baby. Am J Clin Nutr 41, 1032–1041.CrossRefGoogle ScholarPubMed
Yanovski, SZ & Yanovski, JA (2002) Obesity. N Engl J Med 346, 591–602.CrossRefGoogle ScholarPubMed