Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-25T05:00:00.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet

Published online by Cambridge University Press:  09 March 2007

A. J. Batchelor  and
Juliet E. Compston
A. J. Batchelor
Affiliation:
Gastrointestinal Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH
Juliet E. Compston
Affiliation:
Gastrointestinal Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The plasma disappearance of 3H-labelled 25-hydroxyvitamin D3 (25(OH)D3) was studied in healthy volunteers on normal and high-fibre diets, using 3H-labelled tracer doses given intravenously.

2. The mean (±SEM) plasma half-life in the high-fibre-diet group was 19·2±1·7d, which was significantly shorter than in the group on normal diets (27·5±2·1 d, P < 0·02).

3. This finding suggests that a high-fibre diet leads to enhanced elimination of 25(OH)D3 by an action within the intestinal lumen. This may involve interference with an enterohepatic circulation of the metabolite, perhaps by binding of 25(OH)D3 to dietary fibre.

4. The reduced plasma half-life of 3H-labelled 25(OH)D3 associated with a high-fibre diet may explain the development of vitamin D deficiency in Asian immigrants with normal exposure to u.v. light.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 2 , March 1983 , pp. 213 - 216
Copyright
Copyright © The Nutrition Society 1983

References

REFERENCES

Arnaud, S. B., Goldsmith, R. S., Lambert, P. W. & Go, V. L. W. (1975). Proc. Soc. expl. Biol. Med. 46, 570.CrossRefGoogle Scholar
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J. & DeLuca, H. F. (1967). J. clin. Invest. 46, 983.CrossRefGoogle Scholar
Bec, P. H., Bayard, F. & Louvet, J. P. (1972). Rev. Eur. Etudes Clin. Biol. 17, 793.Google Scholar
Bell, P. A. & Kodicek, E. (1969). Biochem. J. 115, 663.CrossRefGoogle Scholar
Dunnigan, M. G., Childs, W. C., Smith, C. M., McIntosh, W. B. & Ford, J. A. (1975). Scott. Med. J. 20, 217.CrossRefGoogle Scholar
Dunnigan, M. G. & Smith, C. M. (1965). Scott. Med. J. 10, 1.CrossRefGoogle Scholar
Edelstein, S., Charman, M., Lawson, D. E. M. & Kodicek, E. (1974). Clin. Sci. Mol. Med. 46, 231.Google Scholar
Ford, J. A., Colhoun, E. M., McIntosh, W. B. & Dunnigan, M. G. (1972). Br. med. J. iii, 446.CrossRefGoogle Scholar
Ford, J. A., McIntosh, W. B. & Dunnigan, M. G. (1976). Adv. expl. Med. Biol. 81, 353.CrossRefGoogle Scholar
Gray, R. W., Weber, H. P., Dominguez, J. H. & Lemann, J. (1974). J. clin. Endocr. Metab. 39, 1045.CrossRefGoogle Scholar
Haddad, J. G. & Hahn, T. J. (1973). Nature, Lond. 244, 515.CrossRefGoogle Scholar
Haddad, J. G. & Rojanasathit, S. (1976). J. clin. Endocr. Metab. 42, 284.CrossRefGoogle Scholar
Hunt, S. P., O'Riordan, J. L. H., Windo, J. & Truswell, A. S. (1976). Br. med. J. ii, 1351.CrossRefGoogle Scholar
Mawer, E. B. (1979). Vitamin D, Basic Research and its Clinical Application, p. 553. Berlin and New York: Walter de Gruyter.CrossRefGoogle Scholar
Mawer, E. B., Backhouse, J., Holman, C. A., Lumb, G. A. & Stanbury, S. W. (1972). Clin. Sci. 43, 413.CrossRefGoogle Scholar
Mawer, E. B., Lumb, G. A., Schaefer, K. & Stanbury, S. W. (1971). Clin. Sci. 40, 39.CrossRefGoogle Scholar
Reinhold, J. G. (1976). Lancet ii, 1132.CrossRefGoogle Scholar
Robertson, I., Kelman, A. & Dunnigan, M. G. (1977). Br. med. J. i, 229.CrossRefGoogle Scholar
Smith, J. E. & Goodman, D. S. (1971). J. clin. Invest. 50, 2159.CrossRefGoogle Scholar
Wills, M. R., Day, R. C., Phillips, J. B. & Bateman, E. C. (1972). Lancet i, 771.CrossRefGoogle Scholar