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Redistribution of vitamin A in tissues of rats with imposed chronic confinement stress

Published online by Cambridge University Press:  09 March 2007

Kiwao Nakano  and
Akihito Morita
Kiwao Nakano
Affiliation:
Department of Nutritional Regulation, The Research Institute for Biochemical Regulation, Nagoya University, Chikusa, Nagoya 464, Japan
Akihito Morita
Affiliation:
Department of Nutritional Regulation, The Research Institute for Biochemical Regulation, Nagoya University, Chikusa, Nagoya 464, Japan
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Abstract

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1. The effect of confinement stress on the metabolism of vitamin A was studied in ratsby following changes in tissue distribution of the vitamin for 29 d. In order to minimizepredicted errors which might result from fluctuation of vitamin A intake, the effect of the stress was investigated in rats fed on a vitamin A-free diet.

2. Daily stress for 6 h induced an enlargement of the adrenals with a concomitant involution of the thymus and spleen, values returning to normal within 11–15 d.

3. The stress caused an immediate decrease in the content of vitamin A in serum.

4. Feeding rats a vitamin A-free diet resulted in a significant increase in the vitamin Acontent of the kidney. Imposing stress on these rats inhibited markedly the increase in kidney vitamin A content.

5. The stress produced no appreciable change in levels of the vitamin in the liver andtestes.

6. There was a preferential accumulation of the vitamin in the adrenals of the stress-imposed rats even though they were fed on a vitamin A-free diet.

7. In conclusion, the results of the present study demonstrated that chronic immobilization stress produced marked tissue-dependent changes in their vitamin A content.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 47 , Issue 3 , May 1982 , pp. 645 - 652
Copyright
Copyright © The Nutrition Society 1982

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