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Quantitative significance of measuring trimethylselenonium in urine for assessing chronically high intakes of selenium in human subjects†

Published online by Cambridge University Press:  09 March 2007

M. Janghorbani ,
Y. Xia ,
P. Ha ,
P. D. Whanger ,
J. A. Butler ,
J. W. Olesik  and
L. Daniels
M. Janghorbani
Affiliation:
BioChemAnalysis Corp. and the Center for Stable Isotope Research Inc., 2201 West Campbell Park Drive, Chicago, IL, USA
Y. Xia
Affiliation:
Chinese Academy of Preventive Medicine, Institute of Nutrition and Food Hygiene, Beijing, People's Republic of China
P. Ha
Affiliation:
Chinese Academy of Preventive Medicine, Institute of Nutrition and Food Hygiene, Beijing, People's Republic of China
P. D. Whanger*
Affiliation:
Department of Agricultural Chemistry, Oregon State University, Corvallis, OR 97331, USA
J. A. Butler
Affiliation:
Department of Agricultural Chemistry, Oregon State University, Corvallis, OR 97331, USA
J. W. Olesik
Affiliation:
Microscopic and Chemical Analysis Research Center, Ohio State University, Columbus, OH, USA
L. Daniels
Affiliation:
Microscopic and Chemical Analysis Research Center, Ohio State University, Columbus, OH, USA
*
*Corresponding author: Professor P. D. Whanger, fax +1 541 737 0497, email [email protected]
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Abstract

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The purpose of the present study was to investigate the effects of Se restriction on the excretion of Se in men who had consumed high levels of this element during their entire lives. With the use of stable isotopes of Se as selenite, the excretion of methylated Se in urine was investigated in Chinese men (n 10) who had habitual chronic high intakes of this element. The relationship between either urine Se or trimethylselenonium (TMSe) to the estimated long-term Se intake was not linear over the entire range of intake, which was also true for the infusion of labelled selenite. A non-linear relationship was also found between urine TMSe and urine Se both for TMSe arising from catabolism of endogenous body Se and that from infused selenite. The data suggest a close precursor–product relationship of urine Se and its TMSe component based on the nearly identical specific activities for these two selenocompounds. Although dimethylselenide in breath was not measured in the present study, combining urinary TMSe with this breath test may be more useful in the assessment of long-term Se status.

Keywords

SeleniumChinese menUrineStable isotopes
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 4 , October 1999 , pp. 291 - 297
Copyright
Copyright © The Nutrition Society 1999

Footnotes

†

Presented at the annual meetings of Experimental Biology 97 and 98 in New Orleans, LA, USA and in San Francisco, CA, USA and published in abstract forms: FASEB Journal (1997) 11, A359 and FASEB Journal (1998) 12, A524. Published with the approval of the Oregon State University Agricultural Experiment Station as Technical paper no. 11, 385.

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