Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-07-06T19:06:28.278Z Has data issue: false hasContentIssue false
  • English
  • Français

Protective effect of zinc supplementation against copper toxicosis in sheep

Published online by Cambridge University Press:  09 March 2007

I. Bremner ,
B. W. Young  and
C. F. Mills
I. Bremner
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
B. W. Young
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
C. F. Mills
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A study has been made of the effects of dietary zinc supplementation on the development of copper toxicosis in three groups each of eight 12-week-old lambs.

2. None of the lambs receiving 420 mg Zn/kg diet developed Cu toxicosis in the 24-week experimental period, compared with three in the control group receiving 43 mg Zn/kg and possibly one in the group receiving 220 mg Zn/kg.

3. Liver Cu concentrations were reduced by up to 40% in the Zn-supplemented animals, with concomitant reductions, especially in the early stages of the experiment, in the extent of liver damage, as assessed by measurement of plasma aspartate aminotransferase (EC 2.6.1.1) and arginase (EC 3.5.3.1) activities.

4. Plasma and liver Zn concentrations were increased only slightly in the lambs receiving the Zn-supplemented diets, and the only indication of possible toxic effects of the Zn supplements was the development of a slight anaemia in those animals receiving 420 mg Zn/kg diet.

5. The results suggest that the incidence of Cu toxicosis in sheep may be controlled by increasing their dietary Zn intake.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 36 , Issue 3 , November 1976 , pp. 551 - 561
Copyright
Copyright © The Nutrition Society 1976

References

Bremner, I. (1974). Q. Rev. Biophys. 7, 75.CrossRefGoogle Scholar
Bremner, I. (1976). Br. J. Nutr. 35, 245.CrossRefGoogle Scholar
Bremner, I. & Marshall, R. B. (1974 a). Br. J. Nutr. 32, 283.CrossRefGoogle Scholar
Bremner, I. & Marshall, R. B. (1974 b). Br. J. Nutr. 32, 293.CrossRefGoogle Scholar
Bremner, I. & Young, B. W. (1976). Biochem. J. 155, 631.CrossRefGoogle Scholar
Chvapil, M., Ryan, J. N. & Zukoski, C. F. (1972). Proc. Soc. exp. Biol. Med. 140, 642.CrossRefGoogle Scholar
Coleman, C. B. & Matrone, G. (1969). Biochim. biophys. Acta 177, 106.CrossRefGoogle Scholar
Cornelius, C. E., Douglas, G. M., Gronwald, R. R. & Freedland, R. A. (1963). Cornell Vet. 53, 181.Google Scholar
Dickie, A. C., Gibson, P. F. & Albert-Recht, F. (1970). Ann. clin. Biochem. 7, 158.CrossRefGoogle Scholar
Goldfischer, S. & Sternlieb, I. (1968). Am. J. Path. 53, 883.Google Scholar
Hogan, K. G., Money, D. F. L. & Blayney, A. (1968). N.Z. Jl Agric. Res. 11, 435.CrossRefGoogle Scholar
Ishmael, J., Gopinath, C. & Howell, J. McC. (1971). Res. vet. Sci. 12, 358.CrossRefGoogle Scholar
Ishmael, J., Gopinath, C. & Howell, J. McC. (1972). Res. vet. Sci. 13, 22.CrossRefGoogle Scholar
Lindquist, R. R. (1967). Am. J. Path. 51, 471.Google Scholar
Lindquist, R. R. (1968). Am. J. Path. 53, 903.Google Scholar
McCosker, P. J. (1968). Res. vet. Sci. 9, 103.CrossRefGoogle Scholar
Mills, C. F. (1974). In Trace Element Metabolism in Animals, Vol. 2, p. 79 [Hoekstra, W. G., Suttie, J. W., Ganther, H. E. and Mertz, W., editors]. Baltimore, Maryland: University Park Press.Google Scholar
Ott, E. A., Smith, W. H., Harrington, R. B. & Beeson, W. M. (1966). J. Anim. Sci. 25, 414.CrossRefGoogle Scholar
Ott, E. A., Smith, W. H., Harrington, R. B., Parker, H. E. & Beeson, W. M. (1966). J. Anim. Sci. 25, 432.CrossRefGoogle Scholar
Ross, D. B. (1966). Br. vet. J. 122, 279.CrossRefGoogle Scholar
Settlemire, C. T. & Matrone, G. (1967). J. Nutr. 92, 159.CrossRefGoogle Scholar
Smith, B. S. W. & Wright, H. (1975). J. comp. Path. Ther. 85, 299.CrossRefGoogle Scholar
Stake, P. E., Miller, W. J., Gentry, R. P. & Neathery, M. W. (1975). J. Anim. Sci. 40, 132.CrossRefGoogle Scholar
Suttle, N. F. & Mills, C. F. (1966). Br. J. Nutr. 20, 135.CrossRefGoogle Scholar
Todd, J. R. (1969). Proc. Nutr. Soc. 28, 189.CrossRefGoogle Scholar
Todd, J. R. & Thompson, R. H. (1963). Br. vet. J. 119, 161.CrossRefGoogle Scholar
Van Campen, D. R. & Scaife, P. U. (1967). J. Nutr. 91, 473.CrossRefGoogle Scholar
Varley, H. (1962). In Practical Clinical Biochemistry, p. 313. London: W. Heinemann Ltd.Google Scholar
Wallace, L. R. (1948). J. agric. Sci., Camb. 38, 243.CrossRefGoogle Scholar