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Protective effect of zinc supplementation against copper toxicosis in sheep

Published online by Cambridge University Press:  09 March 2007

I. Bremner ,
B. W. Young  and
C. F. Mills
I. Bremner
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
B. W. Young
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
C. F. Mills
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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1. A study has been made of the effects of dietary zinc supplementation on the development of copper toxicosis in three groups each of eight 12-week-old lambs.

2. None of the lambs receiving 420 mg Zn/kg diet developed Cu toxicosis in the 24-week experimental period, compared with three in the control group receiving 43 mg Zn/kg and possibly one in the group receiving 220 mg Zn/kg.

3. Liver Cu concentrations were reduced by up to 40% in the Zn-supplemented animals, with concomitant reductions, especially in the early stages of the experiment, in the extent of liver damage, as assessed by measurement of plasma aspartate aminotransferase (EC 2.6.1.1) and arginase (EC 3.5.3.1) activities.

4. Plasma and liver Zn concentrations were increased only slightly in the lambs receiving the Zn-supplemented diets, and the only indication of possible toxic effects of the Zn supplements was the development of a slight anaemia in those animals receiving 420 mg Zn/kg diet.

5. The results suggest that the incidence of Cu toxicosis in sheep may be controlled by increasing their dietary Zn intake.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 36 , Issue 3 , November 1976 , pp. 551 - 561
Copyright
Copyright © The Nutrition Society 1976

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