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Prebiotics and synbiotics: concepts and nutritional properties

Published online by Cambridge University Press:  11 January 2019

M. B. Roberfroid
M. B. Roberfroid*
Affiliation:
Université Catholique de Louvain, Department of Pharmaceutical Sciences, Avenue E. Mounier 73, B-1200 Brussels, Belgium
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Abstract

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The main role of diet is to provide enough nutrients to meet the requirements of a balanced diet, while giving the consumer a feeling of satisfaction and well-being. The most recent knowledge in bioscience supports the hypothesis that diet also controls and modulates various functions in the body, and, in doing so, contributes to the state of good health necessary to reduce the risk of some diseases. It is such an hypothesis which is at the origin both of the concept of ‘functional food’ and the development of a new scientific discipline of ‘functional food science’. In the context of this paper the potential ‘functional foods’ to be discussed are the prebiotics and the synbiotics. The prebiotics developed so far are the non-digestible oligosaccharides and especially the non-digestible fructans among which chicory fructans play a major role. The chicory fructans are β (2-1) fructo-oligosaccharides classified as natural food ingredients. They positively affect various physiological functions in such a way that they are already or may, in the future, be classified as functional food ingredients for which claims of functional effects or of disease risk reduction might become authorized. They are classified as prebiotic and have been shown to induce an increase in the number of bifidobacteria in human faecal flora. As part of a synbiotic-type product, they are already bifidogenic at a dose of 2·75 g/d and the effect lasts for at least 7 weeks. The other potential functional effects are on the bioavailability of minerals, but also, and more systemically, on the metabolism of lipids. Potential health benefits may concern reduction of the risk of intestinal infectious diseases, cardiovascular disease, non-insulin-dependent diabetes, obesity, osteoporosis and cancer. However, except for the prebiotic effect, and tentatively the improvement of calcium bioavailability, the evidence to support such effects is still missing in humans though hypotheses already exist to justify nutrition studies.

Keywords

Functional foodsPrebioticsSynbioticsGut floraBifidobacteriaChicory fructansFructooligosaccharides
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , supplement S2: Pre- and Probiotics: Where are We Today? , October 1998 , pp. S197 - S202
Copyright
Copyright © The Nutrition Society 1998

References

Aarsland, A, Chinkes, D & Wolfe, RR (1996) Contributions of de novo synthesis of fatty acids to total VLDV–triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. Journal of Clinical Investigation 98, 2008–2017.Google Scholar
Bouhnik, Y, Flourie, B, Riottot, M, Bisetti, N, Gailing, M, Guibert, A, Bornet, F & Rambaud, J (1996) Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Nutrition and Cancer 26, 21–29.Google Scholar
Canzi, E, Brighenti, F, Casiraghi, MC, Del Puppo, E & Ferrari, A (1995) Prolonged consumption of inulin in ready-to-eat breakfast cereals: effects on intestinal ecosystem, bowel habits and lipid metabolism. Cost 92, Workshop on Dietary Fiber and Fermentation in the Colon. Helsinki, 15–17/04.Google Scholar
Cassidy, MM, Satchithanandam, S, Calvert, RJ, Vahouny, GV & Leeds, AR (1990) Quantitative and qualitative adaptations in gastrointestinal mucin with dietary fiber feeding. In Dietary Fiber: Chemistry, Physiology, and Health Effects, pp. 67–88 [Kritchevsky, D, Binfield, C, Anderson, JW, editors]. Plenum Press, London.Google Scholar
Coudray, C, Bellanger, J, Castiglia-Delavaud, C, Rémésy, C, Vermorel, M & Demigné, C (1997) Effect of soluble and partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. European Journal of Clinical Nutrition 51, 375–380.Google Scholar
Cummings, JH & Roberfroid, MB (1997) A new look at dietary carbohydrate: chemistry, physiology and health. European Journal of Clinical Nutrition 51, 417–423.Google Scholar
Davidson, MH, Synecki, C, Maki, KC & Drenman, KB (1998) Effects of dietary inulin in serum lipids in men and women with hypercholesterolemia. Nutrition Research 3, 503–517.Google Scholar
De Leenheer, L (1996) Production and use of inulin: industrial reality with a promising future. In: Carbohydrates as Organic Raw Materials, vol. III, pp. 67–92 [Van Bekkum, H, Röper, H & Voragen, F, editors]. VCH Publications, New York and Verlagsgesellschaft, Weinheim, Germany.Google Scholar
De Leenheer, L & Hoebregs, H (1994) Progress in the elucidation of the composition of chicory inulin. Starch 46, 193–196.Google Scholar
Delzenne, N, Kok, N, Fiordaliso, M, Deboyser, D, Goethals, F & Roberfroid, M (1993) Dietary fructooligosaccharides and modify lipid metabolism in rats. American Journal of Clinical Nutrition 57, 820S.Google Scholar
Delzenne, N & Roberfroid, MB (1994) Physiological effects of nondigestible oligosaccharides. Lebensmittel Wissenschaft und Technologie 27, 1–6.Google Scholar
Delzenne, N, Aertssens, J, Verplaetse, H, Roccaro, M & Roberfroid, M (1995) Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the rats. Life Sciences 57, 1579–1587.Google Scholar
Ellegärd, L, Andersson, H & Bosaeus, I (1996) Inulin and oligofructose do not influence the absorption of cholesterol, or the excretion of cholesterol, Ca, Mg, Zn, Fe, or bile acids but increases energy excretion in ileostomy subjects. European Journal of Clinical Nutrition 51, 1–5.Google Scholar
Fiordaliso, MF, Kok, N, Desager, JP, Goethals, F, Deboyser, D, Roberfroid, M & Delzenne, N (1995) Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167.10.1007/BF02538270Google Scholar
Fontaine, N, Meslin, JC, Lory, S & Andrieux, C (1996) Intestinal mucin distribution in the germ-free rat and in the heteroxenic rat harbouring a human bacterial flora: effect of inulin in the diet. British Journal of Nutrition 75, 881–892.Google Scholar
Gibson, GR, Beatty, ER, Wang, X & Cummings, JH (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–892.10.1016/0016-5085(95)90192-2Google Scholar
Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125, 1401–1412.10.1093/jn/125.6.1401Google Scholar
Gibson, GR & Wang, X (1994) Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture. FEMS Microbiology Letters 118, 121–128.Google Scholar
Kleessen, B, Sykura, B, Zunft, HJ & Blaut, M (1997) Effects of inulin and lactose on faecal microflora, microbial activity, and bowel habit in elderly constipated persons. American Journal of Clinical Nutrition 65, 1397–1402.Google Scholar
Kok, N, Roberfroid, M & Delzenne, N (1996 a) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats. British Journal of Nutrition 76, 881–890.Google Scholar
Kok, N, Roberfroid, M & Delzenne, N (1996 b) Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism 45, 1547–1550.Google Scholar
Koo, M & Rao, V (1991) Long term effect of bifidobacteria and neosugar on precursor lesions of colonic cancer in mice. Nutrition and Cancer 16, 249–257.Google Scholar
Ohta, A, Motohashi, Y & Sakuma, K (1997) Dietary fructo-oligosaccharides change the intestinal distribution of cal-bindin 9kD in rats. In Non-digestible Oligosaccharides: Healthy Food for the Colon, Proceedings of the International Symposium held at Wageningen, 1997, p. 153 [Hartemink, R, editor]. Heteren, The Netherland, Vermeulen Publications.Google Scholar
Pedersen, A, Sandström, B & VanAmelsvoort, JMM (1997) The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. British Journal of Nutrition 78, 215–222.Google Scholar
Pierre, F, Perrin, P, Champ, M, Bornet, F, Meflah, K & Menanteau, J (1997) Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Research 57, 225–228.Google Scholar
Reddy, BS, Hamid, R & Rao, CV (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 1371–1374.Google Scholar
Roberfroid, MB (1995) A functional food: chicory fructooligosaccharides, a colonic food with prebiotic activity. World of Ingredients March–April, 42–44.Google Scholar
Roberfroid, MB, Bornet, F, Bouley, C & Cummings, JH (1995) Colonic microflora: nutrition and health. Nutrition Review 53, 127–130.Google Scholar
Roberfroid, MB (1996) Functional effects of food components and the gastrointestinal system: chicory fructooligosaccharides. Nutrition Review 54, S38–S42.Google Scholar
Roberfroid, MB, Van Loo, JAE & Gibson, GR (1997) A review of the bifidogenic nature of chicory inulin and its hydrolysis products. Journal of Nutrition 128, 11–19.Google Scholar
Roberfroid, MB & Delzenne, N (1998) Dietary fructans. Annual Review of Nutrition 18, 117–143.Google Scholar
Rowlands, IR, Rumney, CJ, Coutts, JT & Lievense, LC (1998) Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced crypt foci in rats. Carcinogenesis 19, 281–285.Google Scholar
Satchithanandam, S, Vargofcak-Apker, M, Calvert, RJ, Leeds, AR & Cassidy, MM (1990) Alteration of gastrointestinal mucin by fiber feeding in the rat. Journal of Nutrition 120, 1179–1184.Google Scholar
Taper, H, Delzenne, N & Roberfroid, MB (1997) Growth inhibition of transplantable mouse tumors by non digestible carbohydrates. International Journal of Cancer 71, 1109–1112.Google Scholar
van den Heuvel, EGHM & Schaafsma, G (1997) A double blind cross-over trial on the effect of fructo-oligosaccharides on calcium absorption in 15–18 year old males. American Journal of Clinical Nutrition (submitted).Google Scholar
Van Loo, J, Coussement, P, De Leenheer, L, Hoebregs, H & Smits, G (1995) On the presence of inulin and oligofructose as natural ingredients in the western diet. CRC Critical Review in Food Sciences Nutrition 35, 525–552.Google Scholar
Wang, X & Gibson, GR (1993) Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. Journal of Applied Bacteriology 75, 373–380.10.1111/j.1365-2672.1993.tb02790.xGoogle Scholar
Younes, H, Demigné, C & Rémésy, C (1996) Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat. British Journal of Nutrition 75, 301–314.Google Scholar