Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-29T01:44:05.811Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma zinc as an indicator of zinc status in rats

Published online by Cambridge University Press:  24 July 2007

P. J. Wilkins ,
P. C. Grey  and
I. E. Dreosti
P. J. Wilkins
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
P. C. Grey
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
I. E. Dreosti
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Standard zinc solutions for the atomic absorption analysis of rat plasma were prepared to contain 14% (w/v) of sucrose. In this way the problems of sample nebulization were overcome with a minimum of manipulation before assay.

2. Plasma Zn concentrations in rats were found to fall by approximately 40% (from 1.2 to 0.7 μg/ml) after 1 d on a Zn-deficient (< 0.25 ppm) diet. Thereafter, the fall became less marked and after 5 d the concentrations usually varied between 0.4 and 0.6 μg/ml.

3. A single oral dose (20–200 μg) of Zn was reflected in high plasma Zn concentrations in the depleted rats 1.75 h after dosing, but to a much lesser extent in animals receiving 10–60 ppm Zn in their diet before dosing.

4. It is suggested that the plasma Zn response to a single oral dose of zinc sulphate may provide a useful method for the detection of a subnormal Zn status in individual farm animals without the necessity of determining breed norms.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 27 , Issue 1 , January 1972 , pp. 113 - 120
Copyright
Copyright © The Nutrition Society 1972

References

Davis, P. N., Norris, L. C. & Kratzer, F. H. (1962). J. Nutr. 78, 445.CrossRefGoogle Scholar
Dawson, J. B. & Walker, B. E. (1969). Clinica chim. Acta 26, 465.CrossRefGoogle Scholar
Dreosti, I. E. & Quicke, G. V. (1968). Br. J. Nutr. 22, I.CrossRefGoogle Scholar
Dreosti, I. E., Tao, S. & Hurley, L. S. (1968). Proc. Soc. exp. Biol. Med. 128, 169.CrossRefGoogle Scholar
Girard, M. L. (1968). Clinica chim. Acta 20, 243.CrossRefGoogle Scholar
Hackley, M. B., Smith, J. C. & Halsted, J. A. (1968). Clin. Chem. 14, I.CrossRefGoogle Scholar
Hurley, L. S. (1969). Am. J. clin. Nutr. 22, 1332.CrossRefGoogle Scholar
Hurley, L. S. & Swenerton, H. (1966). Proc. Soc. exp. Biol. Med. 123, 692.CrossRefGoogle Scholar
Mills, C. F., Dalgarno, A. C., Williams, R. B. & Quarterman, J. (1967). Br. J. Nutr. 21, 751.CrossRefGoogle Scholar
Mills, C. F., Quarterman, J., Chesters, J. K., Williams, R. B. & Dalgarno, A. C. (1969). Am. J. clin. Nutr. 22, 1240.CrossRefGoogle Scholar
Parisi, A. F. & Vallee, B. L. (1970). Biochemistry Easton. 9, 2421.CrossRefGoogle Scholar
Pate, F. M., Miller, W. J., Blackmon, D. M. & Gentry, R. P. (1970). J. Nutr. 100, 1259.CrossRefGoogle Scholar
Prasad, A. S., Oberleas, D. & Halsted, J. A. (1965). J. Lab. din. Med. 66, 508.Google Scholar
Sandstead, H. H. (1968). Nutrition Today 3, 12.CrossRefGoogle Scholar
Swenerton, H. & Hurley, L. S. (1968). J. Nutr. 95, 8.CrossRefGoogle Scholar
Underwood, E. J. (1962). Truce Elements in Human and Animal Nutrition 2nd ed. New York: Academic Press Inc.Google Scholar