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Plasma zinc as an indicator of zinc status in rats

Published online by Cambridge University Press:  24 July 2007

P. J. Wilkins ,
P. C. Grey  and
I. E. Dreosti
P. J. Wilkins
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
P. C. Grey
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
I. E. Dreosti
Affiliation:
Department of Biochemistry, University of Natal, Pietermaritxburg, Republic of South Africa
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Abstract

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1. Standard zinc solutions for the atomic absorption analysis of rat plasma were prepared to contain 14% (w/v) of sucrose. In this way the problems of sample nebulization were overcome with a minimum of manipulation before assay.

2. Plasma Zn concentrations in rats were found to fall by approximately 40% (from 1.2 to 0.7 μg/ml) after 1 d on a Zn-deficient (< 0.25 ppm) diet. Thereafter, the fall became less marked and after 5 d the concentrations usually varied between 0.4 and 0.6 μg/ml.

3. A single oral dose (20–200 μg) of Zn was reflected in high plasma Zn concentrations in the depleted rats 1.75 h after dosing, but to a much lesser extent in animals receiving 10–60 ppm Zn in their diet before dosing.

4. It is suggested that the plasma Zn response to a single oral dose of zinc sulphate may provide a useful method for the detection of a subnormal Zn status in individual farm animals without the necessity of determining breed norms.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 27 , Issue 1 , January 1972 , pp. 113 - 120
Copyright
Copyright © The Nutrition Society 1972

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