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Plasma lipid concentrations in children with cystic fibrosis: the value of a high-fat diet and pancreatic supplementation

Published online by Cambridge University Press:  10 October 2007

Graham C. Burdge ,
Alissa J. Goodale ,
Catherine M. Hill ,
Penny J. Halford ,
Elizabeth J. Lambert ,
Anthony D. Postle  and
Christopher J. Rolles
Graham C. Burdge
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
Alissa J. Goodale
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
Catherine M. Hill
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
Penny J. Halford
Affiliation:
University of Southampton, Bassett Crescent East, Southampton SO9 3TU
Elizabeth J. Lambert
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
Anthony D. Postle
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
Christopher J. Rolles
Affiliation:
Departments of Child Health. Southampton General Hospital, Tremona Road, Southampton SO9 4XY and Human Nutrition
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Abstract

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Impaired digestion of dietary fat is an almost universal feature of cystic fibrosis (CF) which results in low concentrations of essential fatty acids in plasma lipids. We have evaluated the effect of a high-lipid diet and pancreatic enzyme supplementation, using enteric-coated microsphere preparations, on plasma lipid concentrations in paediatric CF patients. Absorption of dietary lipid was comparable between control and CF subjects. This resulted in plasma cholesterol, triacylglycerol, total phosphatidylcholine and individual phosphatidylcholine molecular species concentrations in CF patients which were in the same range as those in controls. Normal values for these variables were also found in patients with clinically detectable liver disease. These results show that present dietary management of CF patients supports normal plasma lipid concentrations.

Keywords

Cystic fibrosisPlasma lipidsPlasma phospholipidsChildhood
Type
High Diets in Cystic Fibrosis
Information
British Journal of Nutrition , Volume 71 , Issue 6 , June 1994 , pp. 959 - 964
Copyright
Copyright © The Nutrition Society 1994

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