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Physical state of meal affects gastric emptying, cholecystokinin release and satiety

Published online by Cambridge University Press:  09 March 2007

A. Santangelo ,
M. Peracchi ,
D. Conte ,
M. Fraquelli  and
M. Porrini
A. Santangelo*
Affiliation:
Department of Food Science and Technology, Nutrition Section, University of Milan, via Celoria 2, 20133 Milan, Italy
M. Peracchi
Affiliation:
Department of Gastroenterology, Institute of Medical Science, University of Milan, IRCCS Hospital, via F. Sforza 35, 20122 Milan, Italy
D. Conte
Affiliation:
Department of Gastroenterology, Institute of Medical Science, University of Milan, IRCCS Hospital, via F. Sforza 35, 20122 Milan, Italy
M. Fraquelli
Affiliation:
Department of Gastroenterology, Institute of Medical Science, University of Milan, IRCCS Hospital, via F. Sforza 35, 20122 Milan, Italy
M. Porrini
Affiliation:
Department of Food Science and Technology, Nutrition Section, University of Milan, via Celoria 2, 20133 Milan, Italy
*
*Alessandra Santangelo, fax +39 2 70 63 86 25, email [email protected]
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Abstract

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To verify the influence of food consistency on satiety mechanisms we evaluated the effects of the same meal in solid–liquid (SM) and homogenized (HM) form on satiety sensation, gastric emptying rate and plasma cholecystokinin (CCK) concentration. Eight healthy men, aged 21-28 (mean 24·5) years were given two meals (cooked vegetables 250 g, cheese 35 g, croutons 50 g and olive oil 25 g, total energy 2573 kJ, with water 300 ml) differing only in physical state: SM and HM. The subjects consumed the meals in randomized order on non-consecutive days. The sensations of fullness, satiety and desire to eat were evaluated by means of a questionnaire, gastric emptying was assessed by ultrasonographic measurement of antral area, and plasma CCK concentration was measured by radioimmunoassay. The vegetable-rich meal was significantly more satiating (P < 0·05) when in the HM form than when eaten in a SM state. Furthermore, the overall gastric emptying time was significantly slowed (255 (sem 11) min after HM v. 214 (sem 12) min after SM; P < 0·05) and CCK peak occurred later (94 (sem 12) min after HM v. 62 (sem 11) min after SM; NS) when the food was consumed in the HM form. Independently of the type of meal, antral area was significantly related to fullness sensations (r2 0·46, P = 0·004). These results demonstrate that meal consistency is an important physical food characteristic which influences both gastric emptying rate and satiety sensation. Moreover, the relationship observed between antral area and fullness sensation confirms that antral distension plays a part in the regulation of eating behaviour.

Keywords

Food consistencyGastric emptyingCholecystokininSatiety
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 6 , December 1998 , pp. 521 - 527
Copyright
Copyright © The Nutrition Society 1998

References

Acalovschi, M, Dumitrascu, DL & Csakany, I (1997) Gastric and gall bladder emptying of a mixed meal are not co-ordinated in liver cirrhosis–a simultaneous sonographic study. Gut 40, 412–417.Google Scholar
Association of Official Analytical Chemists (1984) Official Methods of Analysis, 14th ed. Washington, DC: Association of Official Analytical Chemists.Google Scholar
Bergmann, JF, Chassany, O, Petit, A, Triki, R, Caulin, C & Segrestaa, JM (1992) Correlation between echographic gastric emptying and appetite: influence of psyllium. Gut 33, 1042–1043.Google Scholar
Bolondi, L, Bortolotti, M, Santi, M, Calletti, T, Gaiani, S & Labò, G (1985) Measurement of gastric emptying time by real-time ultrasonography. Gastroenterology 89, 752–759.CrossRefGoogle ScholarPubMed
Bolton, RP, Heaton, KW & Burroughs, LF (1981) The role of dietary fibre in satiety, glucose, and insulin: studies with fruit and fruit juice. American Journal of Clinical Nutrition 34, 211–217.CrossRefGoogle ScholarPubMed
Duan, LP, Zheng, ZT & Li, YN (1993) A study of gastric emptying in non-ulcer dyspepsia using a new ultrasonographic method. Scandinavian Journal of Gastroenterology 28, 355–360.Google Scholar
Holt, SHA, Brand, J, Soveny, C & Hansky, J (1992) Relationship of satiety to postprandial glycaemic, insulin and cholecystokinin responses. Appetite 18, 129–141.Google Scholar
Hulshof, T, de Graaf, C & Weststrate, JA (1993) The effects of preloads varying in physical state and fat content on satiety and energy intake. Appetite 21, 273–286.CrossRefGoogle ScholarPubMed
Jones, KL, Doran, SM, Hveem, K, Bartholomeusz, FDL, Morley, JE, Ming Sun, W, Chatterton, BE & Horowitz, M (1997) Relation between postprandial satiation and antral area in normal subjects. American Journal of Clinical Nutrition 66, 127–132.CrossRefGoogle ScholarPubMed
Kissileff, HR (1984) Satiating efficiency and a strategy for conducting food loading experiments. Neuroscience and Bio-behavioral Reviews 8, 129–135.CrossRefGoogle Scholar
Kissileff, HR (1985) Effects of physical state (liquid-solid) of foods on food intake: procedural and substantive contributions. American Journal of Clinical Nutrition 42, 956–965.Google Scholar
Kissileff, HR, Gruss, LP, Thornton, J & Jordan, HA (1984) The satiating efficiency of foods. Physiology and Behavior 32, 319–332.CrossRefGoogle ScholarPubMed
Kissileff, HR, Pi-Sunyer, FX, Thorton, J & Smith, GP (1981) C-terminal octapeptide of cholecystokinin decreases food intake in man. American Journal of Clinical Nutrition 34, 154–160.Google Scholar
Malagelada, JR (1977) Quantification of gastric solid-liquid discrimination during digestion of ordinary meals. Gastroenterology 72, 1264–1267.CrossRefGoogle Scholar
Malagelada, JR, Go, VLW & Summerskill, WHL (1979) Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals. Digestive Diseases and Sciences 24, 101–110.Google Scholar
Moran, TH & McHugh, PR (1988) Gastric and non-gastric mechanisms for satiety action of cholecystokinin. American Journal of Physiology 254, R628–R632.Google Scholar
Pi-Sunyer, FX, Kissileff, HR, Thorton, J & Smith, GP (1982) C-terminal octapeptide of cholecystokinin decreases food intake in obese men. Physiology and Behavior 29, 627–630.Google Scholar
Porrini, M, Crovetti, R, Riso, P, Santangelo, A & Testolin, G (1995a) Effects of physical and chemical characteristics of food on specific and general satiety. Physiology and Behavior 57, 461–468.CrossRefGoogle ScholarPubMed
Porrini, M, Crovetti, R, Silva, S & Testolin, G (1995b) Evaluation of satiety sensations and food intake after different preloads. Appetite 25, 17–30.Google Scholar
Porrini, M, Santangelo, A, Crovetti, R, Riso, P, Testolin, G & Blundell, JE (1997) Weight, protein, fat, and timing of preloads affect food intake. Physiology and Behavior 62, 563–570.CrossRefGoogle ScholarPubMed
Read, NW & Houghton, LA (1989) Physiology of gastric emptying and pathophysiology of gastroparesis. Gastroenterology Clinics of North America 18, 359–373.CrossRefGoogle ScholarPubMed
Rolls, BJ, Fedoroff, IC, Guthrie, JF & Laster, LJ (1990) Foods with different satiating effects in humans. Appetite 15, 115–126.Google Scholar
Shoelson, SE, Polonsky, KS, Nakabayashi, T, Jaspan, JB & Tager, HS (1986) Circulating forms of somatostatin like immunoreactivity in human plasma. American Journal of Physiology 250, E428–E434.Google Scholar
Smith, GP (1992) The development and proof of the CCK hypothesis of satiety. In Multiple Cholecystokinin Receptors in the CNS, pp. 162–182 [Dourish,, CT, Cooper,, SJ, Iverson, SD and LL, Iverson, editors]. Oxford: Oxford University Press.Google Scholar
Smith, GP & Gibbs, J (1987) The effect of gut peptides on hunger, satiety, and food intake in humans. Annals of the New York Academy of Sciences 499, 132–136.Google Scholar
Tournier, A & Louis-Sylvestre, J (1991) Effect of the physical state of a food on subsequent intake in human subjects. Appetite 16, 17–24.CrossRefGoogle ScholarPubMed
Vincent, R, Roberts, A, Perkins, AC, MacDonald, IA & Spiller, RC (1995) Effect of bran particle size on gastric emptying and small bowel transit in human: a scintigraphic study. Gut 37, 216–219.Google Scholar