Hostname: page-component-745bb68f8f-f46jp Total loading time: 0 Render date: 2025-01-09T15:49:44.155Z Has data issue: false hasContentIssue false
  • English
  • Français

Parenteral nutrition with n-3 lipids in sepsis

Published online by Cambridge University Press:  09 March 2007

K. Mayer ,
H. Grimm ,
F. Grimminger  and
W. Seeger
K. Mayer*
Affiliation:
Medizinische Klinik II der Justus-Liebig-Universität Giessen, Klinikstrasse 36, D – 35392 Gießen, Germany
H. Grimm
Affiliation:
Klinik für Allgemein- und Thoraxchirurgie der Justus-Liebig Universität Giessen, Rudolf-Buchheim-Strasse 7, D - 35392 Giessen, Germany
F. Grimminger
Affiliation:
Medizinische Klinik II der Justus-Liebig-Universität Giessen, Klinikstrasse 36, D – 35392 Gießen, Germany
W. Seeger
Affiliation:
Medizinische Klinik II der Justus-Liebig-Universität Giessen, Klinikstrasse 36, D – 35392 Gießen, Germany
*
*Corresponding author: Dr K. Mayer, fax +49 (641) 99 4 2359, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S1 , January 2002 , pp. S69 - S75
Copyright
Copyright © The Nutrition Society 2001

References

Andrew, DP, Spellberg, JP, Takimoto, H, Schmits, R, Mak, TW & Zukowski, MM (1998) Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice. European Journal of Immunology 28, 1959–1969.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Atkinson, S, Sieffert, E, Bihari, D & The Guy’s Hospital Intensive Care Group (1998) A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill. Critical Care Medicine 26, 1164–1172.CrossRefGoogle ScholarPubMed
Blok, WL, Debruijn, MFTR, Leenen, PJM, Eling, WMC, Vanrooijen, N, Stanley, ER, Buurman, WA & Vandermeer, JWM (1996) Dietary n-3 fatty acids increase spleen size and postendotoxin circulating TNF in mice: role of macrophages, macrophage precursors, and colony stimulating factor 1. Journal of Immunology 157, 5569–5573.CrossRefGoogle ScholarPubMed
Bone, RC (1996) Sepsis SIRS and CARS. Critical Care Medicine 24, 1125–1128.CrossRefGoogle ScholarPubMed
Bone, RC, Balk, RA, Cerra, FB, Dellinger, RP, Fein, AM, Knaus, WA, Schein, RM & Sibbald, WJ (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference committee. American college of chest physicians/society of critical care medicine. Chest 101, 1644–1655.CrossRefGoogle ScholarPubMed
Bone, RC, Grodzin, CJ & Balk, RA (1997) Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 112, 235–243.CrossRefGoogle ScholarPubMed
Bower, RH, Cerra, FB, Bershadsky, B, Licari, JJ, Hoyt, DB, Jensen, GL, Van Buren, CT, Rothkopf, MM, Daly, JM & Adelsberg, BR (1995) Early enteral administration of a formula (Impact®) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Critical Care Medicine 23, 436–449.CrossRefGoogle ScholarPubMed
Bursten, SL, Federighi, DA, Parsons, P, Harris, WE, Abraham, E, Moore, EE Jr, Moore, FA, Bianco, JA, Singer, JW & Repine, JE (1996) An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. Critical Care Medicine 24, 1129–1136.CrossRefGoogle ScholarPubMed
Calder, PC (1998) Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. Brazilian Journal of Medical and Biological Research 31, 467–490.CrossRefGoogle ScholarPubMed
Caughey, GE, Mantzioris, E, Gibson, RA, Cleland, LG & James, MJ (1996) The effect on human tumor necrosis factor-α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 63, 116–122.CrossRefGoogle ScholarPubMed
Chabot, F, Mitchell, JA, Gutteridge, JM & Evans, TW (1998) Reactive oxygen species in acute lung injury. European Respiratory Journal 11, 745–757.CrossRefGoogle ScholarPubMed
Chao, CY, Yeh, SL, Lin, MT & Chen, WJ (2000) Effects of parenteral infusion with fish-oil or safflower oil on hepatic lipids, plasma amino acids, and inflammatory mediators in septic rats. Nutrition 16, 284–288.CrossRefGoogle ScholarPubMed
Chyi, A & Yeh, S (2000) Effects of dietary fish oil on survival rate, plasma amino acid pattern, and inflammatory-related mediators in diabetic rats with sepsis. Clinical Nutrition 19, 313–318.CrossRefGoogle ScholarPubMed
Connelly, KG & Repine, JE (1997) Markers for predicting the development of acute respiratory distress syndrome. Annual Review in Medicine 48, 429–445.CrossRefGoogle ScholarPubMed
DeCaterina, R, Cybulsky, MI, Clinton, SK, Gimbrone, MA Jr. & Libby, P (1994) The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 14, 1829–1836.CrossRefGoogle Scholar
Dinarello, CA (1997) Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112, 321S–329S.CrossRefGoogle ScholarPubMed
Docke, WD, Randow, F, Syrbe, U, Krausch, D, Asadullah, K, Reinke, P, Volk, HD & Kox, W (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nature Medicine 3, 678.CrossRefGoogle ScholarPubMed
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonnemann, G, van der Meer, JWM, Cannon, JG, Rogers, TS, Klempner, MS, Weber, PC, Schaefer, EJ, Wolff, SM & Dinarello, CA (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.CrossRefGoogle ScholarPubMed
Friedman, G, Silva, E & Vincent, JL (1998) Has the mortality of septic shock changed with time? Critical Care Medicine 26, 2078–2086.CrossRefGoogle ScholarPubMed
Fritsche, KL, Shahbazian, LM, Feng, C & Berg, JN (1997) Dietary fish oil reduces survival and impairs bacterial clearance in C3H/HEN mice challenged with Listeria monocytogenes. Clinical Science 92, 95–101.CrossRefGoogle ScholarPubMed
Gadek, JE, DeMichele, SJ, Karlstad, MD, Pacht, ER, Donahoe, M, Albertson, TE, Van Hoozen, C, Wennberg, AK, Nelson, JL & Noursalehi Mand the Enteral Nutrition in ARDS Study Group (1999) Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Critical Care Medicine 27, 1409–1420.CrossRefGoogle ScholarPubMed
Galban, C, Montejo, JC, Mesejo, A, Marco, P, Celaya, S, Sanchez-Segura, JM, Farre, M & Bryg, DJ (2000) An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Critical Care Medicine 28, 643–648.CrossRefGoogle ScholarPubMed
Gavino, VC & Gavino, GR (1992) Adipose hormone-sensitive lipase preferentially releases polyunsaturated fatty acids from triglyerides. Lipids 27, 950–954.CrossRefGoogle Scholar
Grimminger, F, Dürr, U & Seeger, U (1992) Ligand-operated synthesis of 4-series and 5-series leukotrienes in human neutrophils: critical dependence on exogenous free fatty acid supply. Molecular Pharmacology 41, 757.Google ScholarPubMed
Grimminger, F, Mayer, K, Kiss, L, Wahn, H, Walmrath, D, Bakhdi, S & Seeger, W (1997a) Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: Critical dependence on exogenous free fatty acid supply. American Journal of Respiratory Cell Molecular Biology 16, 317–324.CrossRefGoogle ScholarPubMed
Grimminger, F, Mayer, K, Kiss, L, Walmrath, D & Seeger, W (2000) PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in a model of pulmonary microvascular leukostasis. American Journal of Physiology (Lung Cellular and Molecular Physiology) 278, L268–L275.CrossRefGoogle Scholar
Grimminger, F, Mayer, K, Krämer, H-J, Stevens, J, Walmrath, D & Seeger, W (1993) Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2- versus 3-series prostanoid generation. Journal of Pharmacology and Experimental Therapeutics 267, 259–265.Google ScholarPubMed
Grimminger, F, Wahn, H, Krämer, H-J, Stevens, J, Mayer, K, Walmrath, D & Seeger, W (1995) Differential influence of arachidonic versus eicosapentaenoic acid on experimental pulmonary hypertension - relation to TxA2- versus TxA3- generation. American Journal of Physiology 268, H2252–H2259(Heart Circ. Physiol.).Google Scholar
Grimminger, F, Wahn, H, Mayer, K, Kiss, L, Walmrath, D, Bahkdi, S & Seeger, W (1997b) Arachidonic acid increases, but eicosapentaenoic acid decreases exotoxin induced lung vascular leakage — relation to 4-series versus 5-series leukotriene generation. American Journal of Respiratory Critical Care Medicine 155, 513–519.CrossRefGoogle Scholar
Guidet, B, Plot, O, Masliah, J, Barakett, V, Maury, E, Bereziat, G & Offenstadt, G (1996) Secretory non-pancreatic phospholipase A2 in severe sepsis: relation to endotoxin, cytokines and thromboxane B2. Infection 24, 103–108.CrossRefGoogle ScholarPubMed
Hammarström, S, Hamberg, M, Samuelsson, B, Duell, E, Stawski, M & Voorhees, JJ (1975) Increased concentrations of non-esterified arachidonic acid, 12L-hydroxyeicosatetraenoic acid, prostaglandin E22alpha in the epidermis of psoriasis. Proceedings of the National Academy of Sciences USA 72, 5130.CrossRefGoogle Scholar
Heller, A, Koch, T, Schmeck, J & van Ackern, K (1998) Lipid mediators in inflammatory disorders. Drugs 55, 487–496.CrossRefGoogle ScholarPubMed
Jaume, JC, Mendel, CM, Frost, PH, Greenspan, FS & Laufhton, CW (1996) Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis. Thyroid 6, 79–83.CrossRefGoogle ScholarPubMed
Kox, WJ, Bone, RC, Krausch, D, Docke, WD, Kox, SN, Wauer, H, Egerer, K, Querner, S, Asadullah, K, von Baehr, R & Volk, HD (1997) Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle. Archives of Internal Medicine 157, 389–393.CrossRefGoogle ScholarPubMed
Kragballe, K, Voorhees, JJ & Goetzl, EJ (1987) Inhibition by leukotriene B54-induced activation of human keratinocytes and neutrophils. Journal of Investigative Dermatology 88, 555.CrossRefGoogle ScholarPubMed
Lovegrove, JA, Brooks, CN, Murphy, MC, Gould, BJ & Williams, CM (1997) Use of manufactured foods enriched with fish oil as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. British Journal of Nutrition 78, 223–236.CrossRefGoogle ScholarPubMed
Mancuso, P, Whelan, J, DeMichele, SJ, Snider, CC, Guszcza, JA, Claycombe, KJ, Smith, GT, Gregory, TJ & Karlstad, MD (1997a) Effects of eicosapentaenoic and γ-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. Critical Care Medicine 25, 523–532.CrossRefGoogle ScholarPubMed
Mancuso, P, Whelan, J, DeMichele, SJ, Snider, CC, Guszcza, JA & Karlstad, MD (1997b) Dietary fish oil and fish oil and borage oil suppress intrapulmonary pro-inflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats. Critical Care Medicine 25, 1198–1206.CrossRefGoogle Scholar
May, CL, Southworth, AJ & Calder, PC (1993) Inhibition of lymphocyte protein kinase C by unsaturated fatty acids. Biochemical and Biophysical Research Communications 195, 823–828.CrossRefGoogle ScholarPubMed
Mayer, K, Fegbeutel, C, Sibelius, U, Krämer, HJ, Hattar, K, Seeger, W & Grimminger, F (1998a) Parenteral nutrition with nn-3-fatty acid-based lipid emulsions in septic patients - effects on plasma free fatty acids and lipid mediator generation. American Journal of Respiratory and Critical Care Medicine 157, A99(abstr).Google Scholar
Mayer, K, Seeger, W & Grimminger, F (1998b) Clinical use of lipids to control inflammatory disease. Current Opinion in Clinical Nutrition and Metabolic Care 1, 179–184.CrossRefGoogle ScholarPubMed
Meerschaert, J & Furie, MB (1994) Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro. Journal of Immunology 152, 1915–1926.CrossRefGoogle ScholarPubMed
Muller, WA, Weigl, SA, Deng, X & Phillips, DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. Journal of Experimental Medicine 178, 449–460.CrossRefGoogle ScholarPubMed
Murray, MJ, Kumar, M, Gregory, TJ, Banks, PL, Tazelaar, HD & DeMichele, SJ (1995) Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs. American Journal of Physiology 269, H2090–H2099.Google ScholarPubMed
Murray, MJ, Svingen, BA, Holman, RT & Yaksh, TL (1991) Effects of a fish oil diet on pig’s cardiopulmonary response to bacteremia. Journal of Parenteral and Enteral Nutrition 15, 152–158.CrossRefGoogle Scholar
Murray, MJ, Svingen, BA, Yaksh, TL & Holman, RT (1993) Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acids-enriched diets. American Journal of Physiology 265, E920–E927.Google Scholar
Peterson, J, Bihain, BE, Bengtsson-Olivecrona, G, Deckelbaum, RJ, Carpentier, YA & Olivecrona, T (1990) Fatty acid control of lipoprotein lipase: A link between energy metabolism and lipid transport. Proceedings of the National Academy of Sciences USA 87, 909.CrossRefGoogle ScholarPubMed
Pscheidl, E, Reisch, S & Rugheimer, E (1994) Chemically defined structured lipids with w-3 fatty acids maintain splanchic blood flow in a low-dose continuous endotoxin model. Infusionstherapie und Transfusionsmedizin 21, 380–387.Google Scholar
Quinlan, GJ, Lamb, N, Tilley, R, Evans, TM & Gutteridge, JMC (1997) Plasma hypoxantine levels in ARDS: implications for morbidity and mortality. American Journal of Respiratory Critical Care Medicine 155, 479–484.CrossRefGoogle Scholar
Robin, AP, Askanazi, J, Greenwood, MRC, Carpentier, YA, Gump, FE & Kinney, JM (1981) Lipoprotein lipase activity in surgical patients. Influence of trauma and sepsis. Surgery 90, 401–408.Google Scholar
Rustan, AC, Hustvedt, BE & Drevon, CA (1998) Postprandial decrease in plasma unesterified fatty acids during n-3 fatty acid feeding is not caused by accumulation of fatty acids in adipose tissue. Biochimica et Biophysica Acta 1390, 245–257.CrossRefGoogle Scholar
Samra, JS, Simpson, EJ, Clark, LM, Forster, CD, Humphreys, SM, MacDonald, LA & Frayn, KN (1996) Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. American Journal of Physiology 34, E834–E839.Google Scholar
Sane, S, Baba, M, Kusano, C, Shirao, K, Andoh, T, Kamada, T & Aikou, T (2000) Eicosapentaenoic acid reduces pulmonary edema in endotoxemic rats. Journal of Surgical Research 93, 21–27.CrossRefGoogle ScholarPubMed
Solomkin, JS, Cotta, LA, Brodt, JK, Hurst, JW & Ogle, CK (1984) Neutrophil dysfunction in sepsis III. Degranulation as a mechanism for nonspecific deactivation. Journal of Surgical Research 36, 407–412.CrossRefGoogle ScholarPubMed
Solomkin, JS, Jenkins, MK, Nelson, RD, Chenoweth, D & Simmons, RL (1981) Neutrophil dysfunction in sepsis II. Evidence for the role of complement activation products in cellular deactivation. Surgery 90, 319–327.Google ScholarPubMed
Sperling, RI, Benincaso, AI, Knoell, CT, Larkin, JK, Austen, KF & Robinson, DR (1993) Dietary omega-3 polyunsaturated fatty acids inhibit phophoinositide formation and chemotaxis in neutrophils. Journal of Clinical Investigation 91, 651–660.CrossRefGoogle Scholar
Spertini, O, Luscinskas, FW, Gimbrone, MA Jr. & Tedder, TF (1992) Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. Journal of Experimental Medicine 175, 1789–1792.CrossRefGoogle ScholarPubMed
Suter, PM & Ricou, B (1998) Cytokines and lung injury. Update in Intensive Care and Emergency Medicine 30, 41–53.CrossRefGoogle Scholar
Terano, T, Shiina, T & Tamura, Y (1996) Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals. Lipids 31, S301–S304.CrossRefGoogle ScholarPubMed
Unterberg, A, Wahl, M, Hammersen, F & Baethmann, A (1987) Permeability and vasomotor response of celebral vessels during exposure to arachidonic acid. Acta Neuropathology 73, 209.CrossRefGoogle Scholar
Volk, HD, Reinke, P & Döcke, WD (2000) Clinical aspects: from systemic inflammation to immunoparalysis. Chemical Immunology 74, 162–177.Google ScholarPubMed
Wallace, FA, Miles, EA & Calder, PC (2000) Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages. Cytokine 12, 1374–1379.CrossRefGoogle ScholarPubMed
Weber, C, Erl, W, Pietsch, A, Danesch, U & Weber, PC (1995) Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-α Arteriosclerosis. Thrombosis, and Vascular Biology 15, 622–628.CrossRefGoogle Scholar
Weber, C & Springer, TA (1998) Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration. Journal of Immunology 161, 6825–6834.CrossRefGoogle ScholarPubMed
Weissman, C (1990) The metabolic response to stress: an overview and update. Anesthesiology 73, 308–327.CrossRefGoogle ScholarPubMed
Wheeler, AP & Bernard, GR (1999) Treating patients with severe sepsis. New England Journal of Medicine 340, 207–214.CrossRefGoogle ScholarPubMed
Yao, YM, Redl, H, Bahrami, S & Schlag, G (1998) The inflammatory basis of trauma/shock-associated multiple organ failure. Inflammation Research 47, 201–210.CrossRefGoogle ScholarPubMed