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Olive oil and rapeseed oil differ in their effect on plasma low-density lipoprotein metabolism in the guinea-pig

Published online by Cambridge University Press:  09 March 2007

Maria Luz Fernandez ,
Anthony E. Soscia ,
Gwo-Shing Sun ,
Mark Tosca ,
Donald J. McNamara  and
Bruce E. McDonald
Maria Luz Fernandez
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Anthony E. Soscia
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Gwo-Shing Sun
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Mark Tosca
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Donald J. McNamara
Affiliation:
Department of Nutritional Sciences and Interdisciplinary Nutritional Sciences Program, University of Arizona. Tucson AZ 85721, USA
Bruce E. McDonald
Affiliation:
Department of Foods and Nutrition, University of Manitoba, Winnipeg, CanadaR3T 2N2
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Abstract

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The effects of olive oil and rapeseed oil, two different high-o1eic-acid oils, on plasma LDL and hepatic cholesterol metabolism were compared in guinea-pigs. Animals were fed on semipurified diet containing 150 g fat/kg as either olive oil (OL), rapeseed oil plus 100 g palm oil/kg (C-P) or olive oil plus 350 g safflowerseed oil/kg (OL-S). Olive oil was enriched with safllowerseed oil (OL-S diet) to increase linoleic acid and to decrease palmitic acid concentrations, in order to evaluate whether differences in plasma LDL concentrations were due to intrinsic effects of the specific oil (rapeseed or olive oil) or to differences in the content of specific fatty acids. No differences due to dietary fat source were found in plasma total and HDL-cholesterol levels or in LDL composition. Plasma LDL-cholesterol levels were lower on the C-P diet than the OL diet (P < 0·05) while plasma LDL-cholesterol levels in animals fed on the OL-S diet were not significantly different from either dietary group (P > 0·05). The number of hepatic apo B/E (LDL) receptors was on average 25% higher in animals fed on the C-P diet compared with those fed on diets containing olive oil. Likewise, cardiac muscle lipoprotein lipase (EC 3.1.1.34) activity was significantly higher in the C-P group than in the OL and OL-S dietary groups. Dietary fat source had no effect on hepatic cholesterol levels or 3-hydroxy-3-methylglutaryl (HMG) CoA reductase (EC 1.1.1.34) activity. The results indicate that olive oil and rapeseed oil, both rich sources of monoumaturated fatty acids, differ in their effect on LDL metabolism in the guinea-pig.

Keywords

Low-density lipoproteinRapeseed oilLipoprotein lipase
Type
General Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 6 , December 1996 , pp. 869 - 880
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Allain, C. C., Poon, L. C., Chan, C. G. S., Richmond, W. & Fu, P. C. (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry 20, 470–475.Google Scholar
Beynen, A. C., Versluis, A., Katan, M. B. & Van Zutphen, L. F. M. (1987). Interaction of dietary cholesterl with the type of fat and fiber with regard to plasma cholesterol response in rabbits. Nutrition Reports International 35, 355–360.Google Scholar
Carr, T., Andresen, C. J. & Rudel, L. L. (1993). Enzymatic determination of triglyceride, free cholesterol and total cholesterol in tissue lipid extracts. Clinical Biochemistry 26, 30–42.CrossRefGoogle ScholarPubMed
Chan, J. K., Bruce, V. M. & McDonald, B. E. (1991). Dietary α-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. American Journal of Clinical Nutrition 53, 1230–1240.Google Scholar
Cryer, A., Kirtland, J, Jones, H. M. & Gurr, M. I. (1978). Lipoprotein lipase activity in the tissues of guinea pigs exposed to different dietary fats from conception to three months of age. Biochemical Journal 170, 169–172.Google Scholar
Daumerie, C. M., Woollett, L. A. & Dietschy, J. M. (1992). Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proceedings of the National Academy of Sciences, USA 89, 10797–10801.Google Scholar
Eckel, R. H. (1989). Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. New England Journal of Medicine 320, 1060–1068.Google Scholar
Fernandez, M. L., Conde, K. A., Ruiz, L. R., Montano, C., Ebner, J. & McNamara, D. J. (1995). Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs. Lipids 30, 619–626.Google Scholar
Fernandez, M. L., Lin, L. C. K. & McNamara, D. J. (1992). Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation. Journal of Lipid Research 33, 97–109.CrossRefGoogle ScholarPubMed
Fernandez, M. L. & McNamara, D. J. (1989). Dietary fat-mediated changes in hepatic apoprotein B/E receptor in the guinea pig: effect of polyunsaturated, monounsaturated, and saturated fat. Metabolism 38, 1094–1102.Google Scholar
Fernandez, M. L. & McNamara, D. J. (1991). Regulation of cholesterol and lipoprotein metabolism in guinea pigs mediated by dietary fat quality and quantity. Journal of Nutrition 121, 934–943.Google Scholar
Fernandez, M. L. & McNamara, D. J. (1994). Dietary fat saturation and chain length modulate guinea pig hepatic cholesterol metabolism. Journal of Nutrition 124, 331–339.CrossRefGoogle ScholarPubMed
Fernandez, M. L., Yount, N. Y. & McNamara, D. J. (1990). Whole body cholesterol synthesis in the guinea pig. Effects of dietary fat quality. Biochimica et Biophysica Acta 1044, 340–348.Google Scholar
Goldstein, J. L., Basu, S. K. & Brown, M. S. (1983). Receptor-mediated endocytosis of low density lipoprotein in cultured cells. Methods in Enzymology 98, 241–260.Google Scholar
Hegsted, D. M., Ausman, L. M., Johnson, J. A. & Dallal, G. E. (1983). Dietary fat and serum lipids: an evaluation of the experimental data. Journal of Nutrition 57, 875–883.Google Scholar
Hegsted, D. M., McGandy, R. B., Myers, M. L. & Stare, F. J. (1965). Quantitative effects of dietary fat on serum cholesterol in man. American Journal of Clinical Nutrition 17, 281–295.CrossRefGoogle ScholarPubMed
Jansen, H., Hulsmann, W. C., van Zuylen-van Wiggen, A., Struijk, C. B. & Houtsmuller, U. M. T. (1975). Influence of rapeseed oil feeding on the lipase activities of rat heart. Biochemical and Biophysical Research Communications 64, 747–751.CrossRefGoogle ScholarPubMed
Keightley, D. D., Fisher, R. J. & Cressie, N. A. C. (1983). Properties and interpretation of the Woolf and Scatchard plots in analyzing data from steroid receptor assays. Journal of Steroid Biochemistry 19, 1407–1412.CrossRefGoogle Scholar
Keys, A., Anderson, J. T. & Grande, F. (1965). Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism 14, 776–787.Google Scholar
Kiens, B., Essen-Gustavsson, B., Gad, P. & Lithell, H. (1987). Lipoprotein lipase activity and intramuscular triglyceride stores after long-term high-fat and high-carbohydrate diets in physically trained men. Clinical Physiology 7, 1–9.Google Scholar
Kris-Etherton, P. M., Yo, C. Y. & Fosmire, M. A. (1986). The effect of dietary fat saturation on plasma and hepatic lipoproteins in the rat. Journal of Nutrition 114, 1675–1682.CrossRefGoogle Scholar
Lichtenstein, A. H., Ausman, L. M., Carrasco, W., Jenner, J. L., Gualtieri, L. J., Goldin, B. R., Ordovas, J. M. & Schaefer, E. J. (1993). Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arteriosclerosis and Thrombosis 13, 1533–1542.Google Scholar
McDonald, B. E., Gerrard, J. M., Bruce, V. M. & Corner, E. J. (1989). Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. American Journal of Clinical Nutrition 50, 1382–1388.CrossRefGoogle ScholarPubMed
McNamara, D. J. (1992). Dietary fatty acids, lipoproteins and cardiovascular disease. Advances in Food and Nutrition Research 36, 253–351.Google Scholar
Mata, P., Alvarez-Sala, L. A., Rubio, M. J., Nuno, J. & De Oya, M. (1992). Effects of long-term monounsaturated vs polyunsaturated-enriched diets on lipoproteins in healthy men and women. American Journal of Clinical Nutrition 55, 846–850.Google Scholar
Mattson, F. H. & Grundy, S. M. (1985). Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. Journal of Lipid Research 26, 194–202.Google Scholar
Mensink, R. P. & Katan, M. B. (1989). Effect of a diet enriched with monounsaturated or polyunsaturated fatty acids on level of low-density lipoprotein cholesterol in healthy women and men. New England Journal of Medicine 321, 436–441.Google Scholar
Nicolosi, R. J., Ausman, L. M. & Hegsted, M. A. (1991). Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in non-human primates. Atherosclerosis 88, 133–142.Google Scholar
Nordstrom, J. L., Rodwell, V. W. & Mitschelen, J. J. (1977). Interconversion of active and inactive forms of rat liver hydroxy-methyl-glutaryl Co A reductase. Journal of Biological Chemistry 252, 8924–8934.CrossRefGoogle Scholar
Pawar, S. S. & Tidwell, H. C. (1968). Effect of ingestion of unsaturated fat on lipolytic activity of rat tissues. Journal of Lipid Research 9, 334–336.CrossRefGoogle ScholarPubMed
Rudel, L. L., Bond, M. G. & Bullock, B. C. (1985). LDL heterogeneity and atherosclerosis in nonhuman primates. Annals of the New York Academy of Sciences 454, 248–253.CrossRefGoogle ScholarPubMed
Rudel, L. L., Park, J. S., Johnson, F. L. & Babiak, J. (1986). Low density lipoproteins in atherosclerosis. Journal of Lipid Research 27, 465–474.CrossRefGoogle ScholarPubMed
Seetharamaiah, G. S. & Chandrasekhra, N. (1989). Studies in hypocholesterolemic activity of rice bran oil. Atherosclerosis 78, 219–223.Google Scholar
Sirtori, C. R., Tremoli, E., Gatti, E., Montanari, G., Sirtori, M., Colli, S., Gianfranceschi, G., Maderna, P., Dentone, C. Z., Testolin, G. & Galli, C. (1986). Controlled evaluation of fat intake in the Mediterranean diet: comparative activities of olive oil and corn oil on plasma lipids and platelets in high-risk patients. American Journal of Clinical Nutrition 44, 635–642.Google Scholar
Spady, D. K. & Dietschy, J. M. (1988). Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. Journal of Clinical Investigation 81, 300–309.Google Scholar
Valsta, L. M., Jauhianinen, M., Aro, A., Katan, M. B. & Mutanen, M. (1992). Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans. Arteriosclerosis and Thrombosis 12, 50–57.Google Scholar
Wardlaw, G. M. & Snook, J. T. (1990). The effect of diets high in butter, corn oil, and high-oleic acid sunflower oil on serum lipids and apolipoproteins in men. American Journal of Clinical Nutrition 51, 815–821.Google Scholar
Wardlaw, G. M., Snook, J. T., Lin, M.-C., Puangco, M. A. & Kwon, J. S. (1991). Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil. American Journal of Clinical Nutrition 54, 104–110.Google Scholar
Weisenburg Delorme, C. L. & Harris, K. L. (1975). Effects of diet on lipoprotein lipase activity in the rat. Journal of Nutrition 105, 447–451.CrossRefGoogle Scholar