Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-22T19:41:06.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Obesity and the metabolic syndrome: the San Antonio Heart Study

Published online by Cambridge University Press:  09 March 2007

Steven M. Haffner
Steven M. Haffner*
Affiliation:
Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78229–3900, USA
*
Corresponding author: S. M. Haffner, fax +1 210 567 6955, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Obesity, especially visceral adiposity, is a major determinant of the development of type 2 diabetes. Both visceral adiposity and insulin resistance are strongly related to cardiovascular risk factors in diabetic and non-diabetic subjects. One of the areas where the correlation between visceral fat (upper body adiposity) and cardiovascular risk is most apparent is the prediabetic state. We have recently shown that only prediabetic subjects (those who later develop type 2 diabetes) who are insulin resistant and with upper body adiposity have increased triglycerides, decreased HDL cholesterol and high blood pressure.

Keywords

ObesityMetabolic syndromeType 2 diabetesPrediabetic
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue S1 , June 2000 , pp. S67 - S70
Copyright
Copyright © The Nutrition Society 2000

References

Despres, JP, Prud'homme, D, Pouliot, MC, Tremblay, A & Bouchard, C (1991) Estimation of deep abdominal adipose tissue accumulation from simple anthropometric measurements in men. American Journal of Clinical Nutrition 54, 471–477.CrossRefGoogle ScholarPubMed
Haffner, SM & Miettinen, H (1997) Insulin resistance implications for type II diabetes mellitus and coronary heart disease. American Journal of Medicine 103, 152–162.CrossRefGoogle ScholarPubMed
Haffner, SM, Miettenen, H, Gaskill, SP & Stern, MP (1990) Metabolic predictors of hypertension: the San Antonio Heart Study. Archives of Internal Medicine 156, 1994–2000.CrossRefGoogle Scholar
Haffner, SM, Valdez, RA, Hazuda, HP, Mitchell, BD, Morales, PA & Stern, MP (1992) Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 41, 715–722.CrossRefGoogle ScholarPubMed
Liese, AD, Mayer-Davis, EJ & Haffner, SM (1998) Development of the multiple metabolic syndrome: an epidemiologic perspective. Epidemiologic Reviews 2, 157–172.CrossRefGoogle Scholar
Meigs, JB, D'Agostino, RB, Wilson, PWF, Cupples, LA, Nathan, DM & Singer, DE (1997) Risk variable clustering in the insulin resistance syndrome: the Framingham Offspring Study. Diabetes 46, 1594–1600.CrossRefGoogle ScholarPubMed
Pouliot, M, Despres, J & Lemieux, S et al. (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric index of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. American Journal of Cardiology 73, 460–468.CrossRefGoogle ScholarPubMed
Reaven, GM, Chen, Y-DI, Jeppesen, J, Maheux, P & Krauss, RM (1993) Insulin resistance and hyperinsulinemia in individuals with small, dense, low density lipoprotein particles. Journal of Clinical Investigations 92, 141–146.CrossRefGoogle ScholarPubMed
Wei, M, Gaskill, SP, Haffner, SM & Stern, MP (1999) Waist circumference as the best predictor of non-insulin dependent diabetes mellitus (NIDDM) compared to body mass index, waist/hip ratio and other anthropometric measurements in Mexican Americans. A 7-year predictive study. Obesity Research 5, 16–23.CrossRefGoogle Scholar