Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T04:51:22.890Z Has data issue: false hasContentIssue false
  • English
  • Français

Nutritional anaemia in pregnant Beninese women: consequences on the haematological profile of the newborn

Published online by Cambridge University Press:  09 March 2007

Serge Hercberg ,
Pilar GalÁn ,
Michel Chauliac ,
Anne-Marie Masse-Raimbault ,
Michel Devanlay ,
Semiou Bileoma ,
Eusebe Alihonou ,
Isidore Zohoun ,
Jean-Philippe Christides  and
Geneviève Potier De Courcy
Serge Hercberg
Affiliation:
Centre de Recherche sur les Anémies Nutritionnelles, ISTA, CNAM, 292 rue St Martin, Paris F-75003, France
Pilar GalÁn
Affiliation:
Centre de Recherche sur les Anémies Nutritionnelles, ISTA, CNAM, 292 rue St Martin, Paris F-75003, France
Michel Chauliac
Affiliation:
Centre International de I'Enfance, Paris, France
Anne-Marie Masse-Raimbault
Affiliation:
Centre International de I'Enfance, Paris, France
Michel Devanlay
Affiliation:
Hopital Albert Chenevier, Créteil, France
Semiou Bileoma
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Eusebe Alihonou
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Isidore Zohoun
Affiliation:
CNHU et Maternité de la Lagune, Cotonou, Benin
Jean-Philippe Christides
Affiliation:
CNRS, Meudon-Bellevue, France
Geneviève Potier De Courcy
Affiliation:
CNRS, Meudon-Bellevue, France
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. An assessment of iron and folic acid status, blood thick film and haemoglobin (Hb) electrophoresis was performed on 126 pregnant women (and their newborn infants) and in ninety-five menstruating women in Cotonou (Benin).

2. Anaemia (according to the World Health Organization (1972)) was observed in 55% of pregnant women and in 39% of menstruating women.

3. Fe-deficiency was defined as a low serum ferritin concentration (12μg/l or less), combined with a low transferrin saturation (less than 16%) or a high erythrocyte protoporphyrin level (more than 3 μg/g Hb), or both. A moderate elevation in the serum ferritin concentration (between 13 and 50 μg/l), associated with a low transferrin saturation or a high erythrocyte protoporphyrin level, or both, indicated Fe-deficiency in an inflammatory context. Fe-deficiency was present in 73% of pregnant women and in 41% of menstruating women.

4. Folate deficiency (defined as erythrocyte folate below 160 μg/l) was observed in 45% of pregnant women.

5. In pregnant women, anaemia was associated with Fe-deficiency in 83% of cases and with folate deficiency in 48% of cases.

6. Haemoglobinopathies were mainly heterozygous and did not seem to contribute significantly to anaemia. Intensity of malaria was not related to Hb level, but Plasmodium falcipurum was found in 99% of subjects.

7. Hb concentration and mean corpuscular volume were significantly lower in babies born of Fe-deficient mothers than in babies born of Fe-sufficient mothers. Hb concentration in newborn infants was positively correlated with maternal serum ferritin.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 2 , March 1987 , pp. 185 - 193
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Addison, G. M., Beamish, M. R., Hales, C. N., Hodkins, M., Jacobs, A. & Lewellen, P. (1972). Journal of Clinical Pathology 25, 326–329.CrossRefGoogle Scholar
Avery, B. & Ledger, W. J. (1970). Obstetrics and Gynecology 35, 616–624.Google Scholar
Baker, S. J. & DeMaeyer, E. M. (1979). American Journal of Clinical Nutrition 32, 368–417.CrossRefGoogle Scholar
Bezwoda, W. R., Bothwell, T. H., Torrance, J. D., MacPhail, A. P., Charlton, R. W., Kay, G. & Levin, J. (1979). Scandinavian Journal of Haematology 22, 113–120.CrossRefGoogle Scholar
Blake, D. R., Waterworth, R. F. & Bacon, P. A. (1981). British Medical Journal 283. 1147–1148.CrossRefGoogle Scholar
Cook, J. D. (1982). Seminars in Hematology 19, 6–18.Google Scholar
Cook, J. D. & Finch, C. A. (1979). American Journal of Nutrition 32, 2115–2119.Google Scholar
Cook, J. D., Finch, C. A. & Smith, N. J. (1976). Blood 48, 449–455.CrossRefGoogle Scholar
Dallman, P. R., Siimes, M. A. & Stekel, A. (1979). Americun Journal of Clinical Nutrition 33, 86–118.CrossRefGoogle Scholar
DeMaeyer, E. M. & Adiels-Tegman, M. (1985). World Health Statistics Quarterly 38, 302–316.Google Scholar
Elin, R. J., Wolff, S. M. & Finch, C. A. (1977). Blood 49, 147–153.CrossRefGoogle Scholar
Fenton, V., Cavill, I. & Fisher, J. (1977). British Journal of Haematology 37, 145–149.CrossRefGoogle Scholar
Fleming, A. F. (1982). Clinics in Haematology 1, 365–388.CrossRefGoogle Scholar
Gebre-Medhin, M. & Birgegard, G. (1981). Scandinavian Journal of Haematology 27, 247–252.CrossRefGoogle Scholar
Giovanello, T. J., Di Benedetto, G., Palmer, D. W. & Peters, T. Jr. (1968). Journal of Laboratory and Clinical Medicine 71, 874–83.Google Scholar
Hercberg, S. & Galán, P. (1985). Revue Epiéimiologie et Santé Publique 33, 228–239.Google Scholar
Hillmans, R. S. & Finch, C. A. (1985). Red Cell Manual. Philadelphia: F. A. Davis.Google Scholar
Hoffbrand, A. V., Newcombe, F. A. & Mollin, D. L. (1966). Journal of Clinical Pathology 19, 17–23.CrossRefGoogle Scholar
Hussain, M. A. M., Gaafar, T. H., Laulicht, M. & Hoffbrand, A. V. (1977). Archives of Disease in Childhood 46, 801–804Google Scholar
Kelly, A. M., MacDonald, D. J. & MacDougall, A. N. (1978). British Journal of Obstetrics and Gynecology 85, 338–343.CrossRefGoogle Scholar
Kojnin, A. M. & Hershko, C. (1977). British Journal of Haematology 37, 7–16.Google Scholar
Lipschitz, D. A., Cook, J. D. & Finch, C. A. (1974). New England Journal of Medicine 290, 1213–1216.CrossRefGoogle Scholar
Lipschitz, D. A, Simon, M. O., Lynch, S. R., Dugard, J., Bothwell, L. H. & Charlton, R. W. (1971). British Journal of Haematology 21, 289–303.CrossRefGoogle Scholar
Murray, M. J., Murray, A. B., Murray, N. J. & Murray, M. B. (1978). British Journal of Nutrition 39, 627–630.CrossRefGoogle Scholar
Ojo, O. A. (1965). Journal of Tropical Medicine and Hygiene 68, 32–38.Google Scholar
Puolakka, J., Janne, O. & Vihlo, J. R. (1980). Acta Obstetrica et Gynecologica Scandinavica 95, 53–56.CrossRefGoogle Scholar
Rios, E., Lipschitz, D. A., Cook, J. D. & Smith, N. J. (1975). Pediatrics 55, 694–699.CrossRefGoogle Scholar
Sauberlich, H. E., Skala, J. H. & Dowdy, R. P. (1974). In Laboratory Tests for the Assessment of Nutritional Status, pp. 49–60 [Kingand, J. W. and Faulkner, W. R., editors]. Cleveland: C.R.C. Press.Google Scholar
Simic, B. (1973). Food and Nutrition in Africa 10, 19–25.Google Scholar
Van Eyjk, H. G., Kross, M. J., Hoogendoorn, G. A. & Wallenburg, H. C. S. (1978). Clinica Chimica Acta 83, 81–91.CrossRefGoogle Scholar
Vernet-Nyssen, M., Stephan, M., Peron, C., Volle, P. J. & Ciret, P. (1983). In Colloque International de Biologie Prospective, pp. 227–230 [Siest, G., editor]. Paris: Masson.Google Scholar
Voller, A. & de Savigny, D. (1981). In Techniques in Clinical Immunology, 2nd ed., pp. 157–168 [Thomson, R. A., editor]. London: Blackwell.Google Scholar
Walters, G. O., Miller, F. M. & Worvood, M. (1973). Journal of Clinical Pathology 26, 770–772.CrossRefGoogle Scholar
World Health Organization (1972). Nutritional Anaemias. Technical Report Series, no. 53. Geneva: WHO.Google Scholar