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Molecular mechanism of transcriptional control by nuclear vitamin receptors

Published online by Cambridge University Press:  09 March 2007

Shigeaki Kato
Shigeaki Kato*
Affiliation:
The Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–0032, Japan, CREST, Japan Science and Technology, 4–1–8 Honcho, Kawaguchishi, Saitama 332–0012, Japan
*
*Corresponding author: Shigeaki Kato, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, 1-1-1, Bunkyo-ku, Tokyo 113-0032, Japan, tel +81 3 5841 8478, fax +81 3 5841 8477, email [email protected]
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Abstract

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Nuclear receptors for vitamins A and D belong to the nuclear hormone receptor superfamily and act as ligand-inducible transcription factors. Therefore, most of the biological actions of vitamins A and D are now considered to be exerted through nuclear vitamin receptor-mediated gene expression. The vitamin A nuclear receptors compromise six members, three all-trans retinoic acid receptors (RARα, RARβ, RARγ) and three 9-cis retinoic acid receptors (RXRα, RXRβ, RXRγ) (Mangelsdorf et al. 1995). Unlike vitamin A receptors, only one member is identified for vitamin D. The present study investigating the vitamin D receptor function in gene expression in both cell culture and intact animals was undertaken to better understand the actions of the fat-soluble vitamin A and vitamin D at a molecular level.

Keywords

Vitamin DVitamin ANuclear receptorTranscription
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue S2 , December 2000 , pp. S229 - S233
Copyright
Copyright © The Nutrition Society 2000

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