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Modulation of postprandial glycaemia and insulinaemia by cellulose in mixed nutrient combinations

Published online by Cambridge University Press:  09 March 2007

Anupa Siddhu ,
Sudha Sud ,
R. L. Bijlani ,
M. G. Karmarkar  and
Usha Nayar
Anupa Siddhu
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
Sudha Sud
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
R. L. Bijlani
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
M. G. Karmarkar
Affiliation:
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi 110 029, India
Usha Nayar
Affiliation:
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India
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Abstract

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The present study was designed to examine the effect of cellulose (CL) on postprandial glycaemia and insulinaemia when ingested with glucose (G), casein (CS) and maize oil (CO) in various combinations. The study was conducted on five healthy male volunteers, on each of whom five meal tolerance tests were performed. The meals were isoenergetic and consisted of G; G and CL; G, CS and CL; G, CO and CL; G, CS, CO and CL. The meals were administered after an overnight fast. In addition to a fasting venous blood sample, blood was collected 0.5, 1.0, 1.5 and 2.0 h after ingestion for measurement of serum glucose and insulin levels. The glycaemic response to G+CS+CL and G+CS+CO+CL was significantly lower, while the insulinaemic response to G+CL was significantly higher than that to G. Addition of CL to G did not alter the glycaemic response, but accentuated the insulinaemic response. Further addition of CS in isoenergetic meals attenuated the glycaemic response, which may be because of a reduction in the amount of G in the meals. Like CS, CL also seemed to have an insulinotropic effect. The mechanism of the insulinotropic effect of CL cannot be deduced from the present study, but it is possible that like G, CL also stimulates gastric inhibitory peptide (GIP) secretion from the duodenum, which in turn stimulates insulin secretion.

Keywords

CelluloseGlucose tolerance testGlycaemic index
Type
Research Article
Information
British Journal of Nutrition , Volume 62 , Issue 1 , July 1989 , pp. 131 - 137
Copyright
Copyright © The Nutrition Society 1989

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