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A model of magnesium metabolism in young sheep. Magnesium absorption and excretion

Published online by Cambridge University Press:  09 March 2007

A. B. Robson ,
A. C. Field ,
A. R. Sykes  and
A. E. McKinnon
A. B. Robson
Affiliation:
Centre for Computing & Biometrics, Lincoln University, Canterbury, New Zealand
A. C. Field
Affiliation:
Animal & Veterinary Sciences Group, Lincoln University, Canterbury, New Zealand
A. R. Sykes
Affiliation:
Animal & Veterinary Sciences Group, Lincoln University, Canterbury, New Zealand
A. E. McKinnon
Affiliation:
Centre for Computing & Biometrics, Lincoln University, Canterbury, New Zealand
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Abstract

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A model of Mg metabolism in sheep is proposed. It is based on standard Michaelis-Menten enzyme kinetics to describe the transport of Mg across the rumen wall and passive diffusion to describe the absorption of Mg in the hindgut. Factors known to have an effect on Mg metabolism in farm animals, namely the concentrations of K and Mg in the diet, and the physico-chemical conditions within the rumen as determined by the type of diet, are incorporated into the model. Consideration of the rumen as the only site of Mg absorption provided an inadequate mechanistic description of Mg metabolism in sheep. To ensure compatibility between predicted Mg absorption and recent independent data sets for Mg balances, it was necessary to include in the model aspects of Mg absorption that operate in the hindgut. The results from this model suggest that there is a need for a series of experiments to determine the important aspects of Mg transport in the hindgut of sheep. Mechanisms of homeostasis are discussed.

Keywords

MagnesiumMathematical modellingHypomagnesaemiaGrass tetany
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 78 , Issue 6 , December 1997 , pp. 975 - 992
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Agricultural Research Council (1980) The Nutrient Requirements of Ruminant Livestock. Slough: Commonwealth Agricultural Bureaux.Google Scholar
Baldwin, R. L. & Black, J. L. (1979) Simulation of the Effects of Nutritional and Physiological Status on the Growth of Mammalian Tissues: Description and Evaluation of a Computer Program. Animal Research Laboratories Technical Paper no. 6. Melbourne: Commonwealth Scientific and Industrial Research Organization.Google Scholar
Ben-Ghedalia, D., Tagari, H., Zamwel, S. & Bondi, A. (1975) Solubility and net exchange of calcium, magnesium and phosphorus in digesta flowing along the gut of the sheep. British Journal of Nutrition 33, 87–94.CrossRefGoogle ScholarPubMed
Blincoe, C. & Woodin, T. S. (1984) Chemical state of magnesium in plasma. Journal of Inorganic Biochemistry 21, 209–214.CrossRefGoogle ScholarPubMed
British Veterinary Association (1960) Conference on Hypomagnesaemia. London: British Veterinary Association.Google Scholar
Dalley, D. E., Isherwood, P., Sykes, A. R. & Robson, A. B. (1997) Effect of intraruminal infusion of potassium on the site of magnesium absorption within the digestive tract in sheep. Journal of Agricultural Science, Cambridge 129, 99–105.CrossRefGoogle Scholar
Dalley, D. E. & Sykes, A. R. (1989) Magnesium absorption from the large intestine in sheep. Proceedings of the New Zealand Society of Animal Production 49, 229–232.Google Scholar
Dixon, R. & Nolan, J. (1982) Studies on the large intestine of sheep. 1. Fermentation and absorption in sections of the large intestine. British Journal of Nutrition 47, 289–300.CrossRefGoogle ScholarPubMed
Faichney, G. J. (1986). The kinetics of particulate matter in the rumen. In Control of Digestion and Metabolism in Ruminants pp. 173–195 ]Milligan, L. P., Grovum, W. L., Dobson, A., editors[. Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
Ferreira, H. G., Harrison, F. A., Keynes, R. D. & Nauss, A. H. (1966) Observations on the potential across the rumen of sheep. Journal of Physiology 187, 615–630.CrossRefGoogle Scholar
Field, A. C. & Munro, C. S. (1977) The effect of site and quantity on the extent of absorption of Mg infused into the gastro-intestinal tract of sheep. Journal of Agricultural Science, Cambridge 89, 365–371.CrossRefGoogle Scholar
Finco, D. R. (1989). Kidney function. In Clinical Biochemistry of Domestic Animals 4th ed., pp. 496–542 ]Kaneko, J. J., editor[. San Diego, CA: Academic Press, Inc.Google Scholar
Fontenot, J. P., Bunce, G. E., Webb, K. E. & Allen, V. G. (editors) (1983) Proceedings of the John Lee Pratt International Symposium on the Role of Magnesium in Animal Nutrition. Blacksburg, VA: Virginia Polytechnic Institute and State University.Google Scholar
France, J., Gill, M., Thornley, J. H. M. & England, P. (1987) A model of nutrient utilization and body composition in beef cattle. Animal Production 44, 371–385.Google Scholar
Gill, M., Thornley, J. H. M., Black, J. L., Oldham, J. D. & Beever, D. E. (1984) Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep. British Journal of Nutrition 52, 621–649.CrossRefGoogle Scholar
Godfrey, K. (1983) Compartmental Models and their Application. London: Academic Press.Google Scholar
Grace, N. D. (1983). The site of absorption of magnesium in ruminants. In Proceedings of John Lee Pratt International Symposium on the Role of Magnesium in Animal Nutrition pp. 107–120 ]Fontenot, J. P., Bunce, G. E., Webb, K. E., Allen, V. G., editors[. Blacksburg, VA: Virginia Polytechnic Institute and State University.Google Scholar
Grace, N. D., Caple, I. W. & Care, A. D. (1988) Studies in sheep on the absorption of magnesium from a low molecular weight fraction of the reticulo-rumen contents. British Journal of Nutrition 59, 93–108.CrossRefGoogle ScholarPubMed
Grace, N. D. & MacRae, J. C. (1972) Influence of feeding regimen and protein supplementation on the sites of net absorption of magnesium in sheep. British Journal of Nutrition 27, 51–55.CrossRefGoogle ScholarPubMed
Grace, N. D., Ulyatt, M. J. & MacRae, J. C. (1974) Quantitative digestion of fresh herbage by sheep. Journal of Agricultural Science, Cambridge 82, 321–330.CrossRefGoogle Scholar
Johnson, C. L., Helliwell, S. H. & Aubrey Jones, D. A. (1987) Magnesium metabolism in the rumens of lactating dairy cows fed on spring grass. Quarterly Journal of Experimental Physiology 73, 23–31.CrossRefGoogle Scholar
Kemp, A., Deijs, W. B., Hemkes, O. J. & van Es, A. J. H. (1960). Basic source of magnesium metabolism III. Intake and utilization of magnesium from herbage by lactating cows. In Conference on Hypomagnesaemia pp. 23–32. London: British Veterinary Association.Google Scholar
Larvor, P. (1976) 28Mg kinetics in ewes fed normal or tetany prone grass. Cornell Veterinarian 66, 413–429.Google ScholarPubMed
McLean, A. F., Buchan, W. & Scott, D. (1984) Magnesium absorption in mature ewes infused intraruminally with magnesium chloride. British Journal of Nutrition 52, 523–527.CrossRefGoogle Scholar
Martens, H. (1983) Saturation kinetics of magnesium efflux across the rumen wall in heifers. British Journal of Nutrition 49, 153–158.CrossRefGoogle ScholarPubMed
Martens, H. & Blume, I. (1986) Effect of intraruminal sodium and potassium concentrations and of the transmural potential difference on magnesium absorption from the temporarily isolated rumen of sheep. Quarterly Journal of Experimental Physiology 71, 409–415.CrossRefGoogle ScholarPubMed
Martens, H., Gabel, G. & Strozyk, H. (1987) The effect of potassium and the transmural potential difference on magnesium transport across an isolated preparation of sheep rumen epithelium. Quarterly Journal of Experimental Physiology 72, 181–188.CrossRefGoogle ScholarPubMed
Martens, H., Harmeyer, J. & Michael, H. (1978) Magnesium transport by isolated rumen epithelium of sheep. Research in Veterinary Science 24, 161–168.CrossRefGoogle ScholarPubMed
Martens, H. & Rayssiguier, Y. (1980). Magnesium metabolism and hypomagnesaemia. In Proceedings of the 5th International Symposium on Ruminant Physiology pp. 447–466 ]Ruckebush, Y. and Thivend, P., editors[. Lancaster: MTP Press Ltd.Google Scholar
Mitchell, E. E. L. & Gauthier, J. (1987) Advanced Continuous Simulation Language (ACSL). Concord, MA: Mitchell & Gauthier Associates.Google Scholar
Pethick, D. W., Lindsay, D. B., Barker, P. J. & Northrop, A. J. (1981) Acetate supply and utilization by the tissues of sheep in vivo. British Journal of Nutrition 46, 97–110.CrossRefGoogle ScholarPubMed
Quamme, G. A. & Dirks, J. H. (1983). Renal magnesium transport. In Review of Physiology, Biochemistry and Pharmacology Vol. 97, pp. 69–110 ]Ullrich, K., editor[. Berlin: Springer-Verlag.Google Scholar
Reynolds, C. K., Bell, M. C. & Sims, M. H. (1984) Changes in plasma, red blood cell and cerebrospinal fluid mineral concentrations in calves during magnesium depletion followed by repletion with rectally infused magnesium chloride. Journal of Nutrition 114, 1334–1341.CrossRefGoogle ScholarPubMed
Ross, G. J. S. (1980) MLP Maximum Likelihood Program. Lawes Agricultural Trust, Rothamstead Experimental Station.Google Scholar
Scott, D. (1966) The effects of sodium depletion and potassium supplementation upon electrical potentials in the rumen of the sheep. Quarterly Journal of Experimental Physiology 51, 60–69.CrossRefGoogle Scholar
Smith, R. H. & Horn, J. P. (1976). Absorption of magnesium, labelled with magnesium-28, from the stomach of the young steer. In International Symposium on Nuclear Techniques in Animal Production and Health as Related to the Soil/Plant System pp. 253–260. Vienna: International Atomic Energy Agency.Google Scholar
Thornley, J. H. M. (1976) Mathematical Methods in Plant Physiology. London: Academic Press.Google Scholar
Tomas, F. M. & Potter, B. J. (1976 a) The site of magnesium absorption from the ruminant stomach. British Journal of Nutrition 36, 37–45.CrossRefGoogle ScholarPubMed
Tomas, F. M. & Potter, B. J. (1976 b) Interaction between sites of magnesium absorption in the digestive tract of sheep. Australian Journal of Agricultural Research 27, 437–446.CrossRefGoogle Scholar
Tomas, F. M. & Potter, B. J. (1976 c) The effect and site of action of potassium upon magnesium absorption in sheep. Australian Journal of Agricultural Research 27, 873–880.CrossRefGoogle Scholar
van't Klooster, A. Th. (1967) De toestand van calcium, magnesium en enkele andere mineralen in darminhoud en mest van herkauwers in verband met hun resorptie (The status of calcium, magnesium and some other minerals in intestinal contents and manure of ruminants in relation to their resorption). Mededelingen Landbouwhogeschool Wageningen 67, 1–135.Google Scholar
Wilcox, G. E. & Hoff, J. E. (1974) Grass tetany: an hypothesis concerning its relationship with ammonium nutrition of spring grasses. Journal of Dairy Science 57, 1085–1089.CrossRefGoogle ScholarPubMed
Wilson, G. F., Reid, C. S. W., Molloy, L. F., Metson, A. J. & Butler, G. W. (1969) Grass tetany. I. Influence of starch and peanut oil supplements on the plasma magnesium, calcium and phosphorus levels in grazing dairy cows. New Zealand Journal of Agricultural Research 12, 467–488.CrossRefGoogle Scholar
Woodin, T. S. & Blincoe, C. (1985) Distribution of plasma magnesium in various vertebrates. Comparative Biochemistry and Physiology 81A, 507–509.CrossRefGoogle Scholar