Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-05T11:04:42.809Z Has data issue: false hasContentIssue false

Methionine sulphoxide as a source of sulphur-containing amino acids for the young rat

Published online by Cambridge University Press:  06 August 2007

Anne U. Gjøen
Affiliation:
Government Vitamin Institute, Directorate of Fisheries, 5000 Bergen, Norway
L. R. Njaa
Affiliation:
Government Vitamin Institute, Directorate of Fisheries, 5000 Bergen, Norway
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Young male rats were used in five experiments to study the utilization for growth of methionine sulphoxide, and the relationship between the sulphoxide content in the diet and the level of microbiologically determined methionine activity in blood or blood plasma. In one nitrogen-balance experiment methionine and methionine sulphoxide were compared as supplements to a casein diet and a fish-meal diet.

2. Methionine sulphoxide was poorly utilized for growth when tested as the sole sulphur amino acid in an amino acid diet. Substitution of one-third of the sulphoxide with cystine improved utilization so that it approached that of methionine.

3. Methionine alone and in combination with methionine sulphoxide were added to a soya-bean-meal diet. The sulphoxide showed no adverse effect on growth.

4. Fish meal in which methionine had been oxidized to methionine sulphoxide was tested alone and in combinations with unoxidized fish meal. Only when the oxidized meal was given alone was there an appreciable effect on growth. The fish meals used were low in cystine.

5. Whereas both methionine and methionine sulphoxide improved the N balance when a casein diet was given, there was no effect when a fish-meal diet was given.

6. There was a linear relationship between methionine sulphoxide content in the amino acid diets and the methionine activity in the blood plasma. Methionine sulphoxide added to a soya-bean-meal diet or present in oxidized fish meal gave a curvilinear relationship, and the observed activities were lower than with the amino acid diets. Methionine activity in blood could not be used as an indicator of moderate amounts of methionine sulphoxide in protein-containing diets.

Type
Papers of direct relevance to Clinical and Human Nutrition
Copyright
Copyright © The Nutrition Society 1977

References

REFERENCES

Bennett, M. A. (1939). Biochem. J. 33, 1794.CrossRefGoogle Scholar
Cuq, J. L., Provansal, M., Guilleux, F. & Cheftel, C. (1973). J. Fd Sci. 38, 11.CrossRefGoogle Scholar
Dévényi, T., Báti, J., Hallstrøm, B., Trägårdh, Ch., Kralovánszky, P. U. & Mátrai, T. (1974). Acta biochim. biophys. Acad. Sci. Hung. 9, 395.Google Scholar
Ellinger, G. M. & Palmer, R. (1969). Proc. Nutr. Soc. 28, 42A.Google Scholar
Floyd, N. F., Cammaroti, M. S. & Lavine, T. F. (1963). Archs Biochem. Biophys. 102, 343.CrossRefGoogle Scholar
Greenfield, H., Briggs, G. M., Watson, R. H. J. & Yudkin, J. (1969). Proc. Nutr. Soc. 28, 43 A.Google Scholar
Harker, C. S., Allen, P. E. & Clark, H. E. (1968). J. Nutr. 94, 495.CrossRefGoogle Scholar
Lakhanpal, R. K., Harrill, I. & Bowman, F. (1969). J. Nutr. 99, 497.CrossRefGoogle Scholar
Lea, C. H., Parr, L. J. & Carpenter, K. J. (1958). Br. J. Nutr. 12, 297.CrossRefGoogle Scholar
Lunder, T. L. (1972). Analyt. Biochem. 49, 585.CrossRefGoogle Scholar
McLaughlan, J. M., Noel, F., Morrison, A. B. & Campbell, J. A. (1961). Can. J. Biochem. Physiol. 39, 1669.CrossRefGoogle Scholar
Miller, D. S. (1956). J. Sci. Fd Agric. 7, 337.CrossRefGoogle Scholar
Miller, D. S. & Samuel, P. (1968). Proc. Nutr. Soc. 27, 21 A.Google Scholar
Miller, D. S. & Samuel, P. D. (1970). J. Sci. Fd Agric. 21, 616.CrossRefGoogle Scholar
Miller, S. A., Tannenbaum, S. R. & Seitz, A. W. (1970). J. Nutr. 100, 909.CrossRefGoogle Scholar
Njaa, L. R. (1959). Br. J. Nutr. 13, 137.CrossRefGoogle Scholar
Njaa, L. R. (1961). J. Sci. Fd Agric. 12, 757.CrossRefGoogle Scholar
Njaa, L. R. (1962 a). Acta chem. scand. 16, 1359.CrossRefGoogle Scholar
Njaa, L. R. (1962 b). Br. J. Nutr. 16, 571.CrossRefGoogle Scholar
Njaa, L. R. (1963). Fisk.Dir. Skr. 4, no. 5.Google Scholar
Pieni,ąźek, D., Rakowska, M. & Kunachowicz, H. (1975). Br. J. Nutr. 34, 163.CrossRefGoogle Scholar
Pieniąźek, D., Rakowska, M., Szkillądziowa, W. & Grabarek, Z. (1975). Br. J. Nutr. 34, 175.CrossRefGoogle Scholar
Rasekh, J., Stillings, B. R. & Sidwell, V. (1972). J. Fd Sci. 37, 423.CrossRefGoogle Scholar
Slump, P. & Schreuder, H. A. W. (1969). Analyt. Biochem. 27, 182.CrossRefGoogle Scholar
Slump, P. & Schreuder, H. A. W. (1973). J. Sci. Fd Agric. 24, 657.CrossRefGoogle Scholar
Snedecor, G. W. (1956). Statistical Methods Applied to Experiments in Agriculture and Biology, 5th ed., Chapter 12. Ames, Iowa: Iowa State College Press.Google Scholar
Tannenbaum, S. R., Barth, H. & LeRoux, J. P. (1969). J. agric. Fd Chem. 17, 1353.CrossRefGoogle Scholar
Tsuchiya, Y. (1942 a). Bull. agric. chem. Soc. Jap. 18, 23.Google Scholar
Tsuchiya, Y. (1942 b). J. agric. chem. Soc. Jap. 18, 279.Google Scholar