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Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?

Published online by Cambridge University Press:  08 March 2007

Cristovao F. Lima ,
Marisa F. Azevedo ,
Rita Araujo ,
Manuel Fernandes-Ferreira  and
Cristina Pereira-Wilson
Cristovao F. Lima
Affiliation:
Department of Biology, Centre of Biology, School of Sciences, University of Minho, Portugal
Marisa F. Azevedo
Affiliation:
Department of Biology, Centre of Biology, School of Sciences, University of Minho, Portugal
Rita Araujo
Affiliation:
Department of Biology, Centre of Biology, School of Sciences, University of Minho, Portugal
Manuel Fernandes-Ferreira
Affiliation:
Department of Biology, Centre of Biology, School of Sciences, University of Minho, Portugal
Cristina Pereira-Wilson*
Affiliation:
Department of Biology, Centre of Biology, School of Sciences, University of Minho, Portugal
*
*Corresponding author: Dr Cristina Pereira-Wilson, fax +351 253678980, email [email protected]
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Abstract

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Common sage (Salvia officinalis L.) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In the present study, we aimed to verify the antidiabetic effects of an infusion (tea) of common sage, which is the most common form of this plant consumed. Replacing water with sage tea for 14d lowered the fasting plasma glucose level in normal mice but had no effect on glucose clearance in response to an intraperitoneal glucose tolerance test. This indicated effects on gluconeogenesis at the level of the liver. Primary cultures of hepatocytes from healthy, sage-tea-drinking rats showed, after stimulation, a high glucose uptake capacity and decreased gluconeogenesis in response to glucagon. Essential oil from sage further increased hepatocyte sensitivity to insulin and inhibited gluconeogenesis. Overall, these effects resemble those of the pharmaceutical drug metformin, a known inhibitor of gluconeogenesis used in the treatment and prevention of type 2 diabetes mellitus. In primary cultures of rat hepatocytes isolated from streptozotocin (STZ)-induced diabetic rats, none of these activities was observed. The present results seem to indicate that sage tea does not possess antidiabetic effects at this level. However, its effects on fasting glucose levels in normal animals and its metformin-like effects on rat hepatocytes suggest that sage may be useful as a food supplement in the prevention of type 2 diabetes mellitus by lowering the plasma glucose of individuals at risk.

Keywords

Salvia officinalis L.DiabetesMetforminRat hepatocyteHypoglycaemic effects
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 2 , August 2006 , pp. 326 - 333
Copyright
Copyright © The Nutrition Society 2006

References

Alarcon-Aguilar, FJ, Roman-Ramos, R, Flores-Saenz, JL & Aguirre-Garcia, FInvestigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. Phytother Res (2002) 16, 383–386.CrossRefGoogle ScholarPubMed
Amatruda, JM, Salhanick, AI & Chang, CLHepatic insulin resistance in non-insulin-dependent diabetes mellitus and the effects of a sulfonylurea in potentiating insulin action. Diabetes Care 7, (1984Suppl. 1, 4753Google Scholar
Baricevic, D & Bartol, TThe biological/pharmacological activity of the Salvia genus InSage – the Genus Salvia, pp. 143–184 [Kintzios, SE, editor]. Amsterdam: Harwood Academic Publishers. (2000)Google Scholar
Cheng, JT, Liu, IM, Chi, TC, Su, HC & Chang, CGMetforminlike effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat. Horm Metab Res (2001) 33, 727–732.CrossRefGoogle Scholar
Chiasson, JL, Josse, RG, Gomis, R, Hanefeld, M, Karasik, A& Laakso, MAcarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet (2002) 359, 2072–2077.CrossRefGoogle ScholarPubMed
Costacou, T & Mayer-Davis, EJNutrition and prevention of type 2 diabetes. Annu Rev Nutr (2003) 23, 147–170.CrossRefGoogle ScholarPubMed
Day, CTraditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr (1998) 80, 5–6.CrossRefGoogle ScholarPubMed
Dunbar, JC, Schultz, S, Houser, F & Walker, JRegulation of the hepatic response to glucagon – role of insulin, growth-hormone and cortisol. Horm Res (1989) 31, 244–249.CrossRefGoogle ScholarPubMed
Eidi, M, Eidi, A & Zamanizadeh, HEffect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocininduced diabetic rats. J Ethnopharmacol (2005) 100, 310–313.CrossRefGoogle Scholar
Giannouli, AL, Kintzios, SEEssential oils of Salvia spp: examples of intraspecific and seasonal variation. InSage – the Genus Salvia, pp.69–80 [Kintzios, SE, editor]. Amsterdam: Harwood Academic Publishers. (2000)Google Scholar
Guarino, MP, Afonso, RA, Raimundo, N, Raposo, JF & Macedo, MPHepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action. Am J Physiol Gastrointest Liver Physiol (2003) 284, G588–G594.CrossRefGoogle ScholarPubMed
Han, YM, Oh, H, Na, M, Kim, BS, Oh, WK, Kim, BY, Jeong, DG, Ryu, SE, Sok, DE & Ahn, JSPTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull (2005) 28, 1795–1797.CrossRefGoogle ScholarPubMed
HussinAH, & Skett, PLack of effect of insulin in hepatocytes isolated from streptozotocin-diabetic male-rats. Biochem Pharmacol (1988) 37, 1683–1686.CrossRefGoogle Scholar
Jermendy, GCan type 2 diabetes mellitus be considered preventable?. Diabetes Res Clin Pract 68, Suppl. 1, (2005) S73–S81.CrossRefGoogle ScholarPubMed
Klover, PJ & Mooney, RAHepatocytes: critical for glucose hom36eostasis. Int J Biochem Cell Biol (2004) 36, 753–758.CrossRefGoogle Scholar
Lai, LCPrevention of type 2 diabetes. Malays J Pathol (2002) 24,71–76.Google ScholarPubMed
Large, V & Beylot, MModifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin. Diabetes (1999) 48, 1251–1257.CrossRefGoogle ScholarPubMed
Li, WL, Zheng, HC, Bukuru, J & De Kimpe, NNatural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol (2004) 92, 1–21.CrossRefGoogle Scholar
Lima, CF, Andrade, PB, Seabra, RM, Fernandes-Ferreira, M & Pereira-Wilson, CThe drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol (2005) 97, 383–389.CrossRefGoogle ScholarPubMed
Lima, CF, Carvalho, F, Fernandes, E, Bastos, ML, Santos-Gomes, PC, Fernandes-Ferreira, M & Pereira-Wilson, CEvaluation of toxic/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes. Toxicol in Vitro (2004) 18, 457–465.CrossRefGoogle ScholarPubMed
Moldeus, P, Hogberg, J & Orrenius, SIsolation and use of liver cells. Methods Enzymol (1978) 52, 60–71.CrossRefGoogle ScholarPubMed
National Institutes of Health Principles of Laboratory Animal Care. Bethesda, MD: National Institutes of Health. (1985)Google Scholar
Qin, B, Nagasaki, M, Ren, M, Bajotto, G, Oshida, Y & Sato, YGosha-jinki-gan (a herbal complex) corrects abnormal insulin signaling. Evid Based ComplementAlternat Med (2004) 1, 269–276.CrossRefGoogle ScholarPubMed
Roden, M & Bernroider, EHepatic glucose metabolism in humans – its role in health and disease. Best Pract Res Clin Endocrinol Metab (2003) 17, 365–383.CrossRefGoogle ScholarPubMed
Salhanick, AI, Konowitz, P & Amatruda, JMPotentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats. Diabetes (1983) 32, 206–212.CrossRefGoogle ScholarPubMed
Saxena, A & Vikram, NKRole of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 2004) 10, 369–378.CrossRefGoogle ScholarPubMed
Schernthaner, GProgress in the prevention of type 2 diabetes. Wien Klin Wochenschr (2003) 115, 745–757.CrossRefGoogle ScholarPubMed
Simpson, RW, Shaw, JE & Zimmet, PZThe prevention of type 2 diabetes – lifestyle change or pharmacotherapy? A challenge for the 21st century. Diabetes Res Clin Pract (2003) 59, 165–180.CrossRefGoogle ScholarPubMed
Sreenan, S, Sturis, J, Pugh, W, Burant, CF & Polonsky, KSPrevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin and troglitazone. Am J Physiol (1996) 271, E742–E747.Google ScholarPubMed
Stoeckli, R & Keller, UNutritional fats and the risk of type 2 diabetes and cancer. Physiol Behav (2004) 83, 611–615.CrossRefGoogle ScholarPubMed
Williams, G & Pickup, JCHandbook of Diabetes,3rd ed. Malden: Blackwell Publishing. (2004)Google Scholar
Yeh, GY, Eisenberg, DM, Kaptchuk, TJ & Phillips, RSSystematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care (2003) 26, 1277–1294.CrossRefGoogle ScholarPubMed
Yuan, L, Ziegler, R, Hamann, AInhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes. Chin Med J (Engl) (2002) 115, 1843–1848.Google ScholarPubMed