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Metabolic responses to low doses of cyanocobalamin in patients with megaloblastic anaemia

Published online by Cambridge University Press:  09 March 2007

J. F. Adams ,
R. Hume ,
Elizabeth H. Kennedy ,
T. G. Pirrie ,
J. W. Whitelaw  and
A. M. White
J. F. Adams
Affiliation:
Southern General Hospital, Glasgow
R. Hume
Affiliation:
Southern General Hospital, Glasgow
Elizabeth H. Kennedy
Affiliation:
Southern General Hospital, Glasgow
T. G. Pirrie
Affiliation:
Southern General Hospital, Glasgow
J. W. Whitelaw
Affiliation:
Southern General Hospital, Glasgow
A. M. White
Affiliation:
CIBA Research Laboratories, Horsham, Sussex
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Abstract

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1. The metabolic responses to daily treatment with 1 μg cyanocobalamin were studied in sixteen patients with megaloblastic anaemia due to cobalamin deficiency.

2. The fall in serum iron was sluggish in most patients. The pattern of reticulocyte responses varied widely, the most common being a plateau with suboptimal maximal value.

3. Urinary propionic acid excretion before treatment was normal in two out of six patients. A transient rise during treatment was observed in two patients, possibly owing to demands on coenzyme stores. The fall in urinary propionic acid excretion during treatment was slow.

4. Serum vitamin B12 levels rose during treatment. In two patients an abrupt rise was found, possibly owing to release of stored cobalamin into the circulation.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 4 , December 1968 , pp. 575 - 582
Copyright
Copyright © The Nutrition Society 1968

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