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Maximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouth

Published online by Cambridge University Press:  09 March 2007

Mayumi Yoshioka*
Affiliation:
Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL) and Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, Ste-Foy, Quebec G1V 4G2, Canada Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
Makoto Imanaga
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
Hiromi Ueyama
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
Miya Yamane
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
Yoshiko Kubo
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
André Boivin
Affiliation:
Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL) and Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, Ste-Foy, Quebec G1V 4G2, Canada
Jonny St-Amand
Affiliation:
Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL) and Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, Ste-Foy, Quebec G1V 4G2, Canada
Hiroaki Tanaka
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
Akira Kiyonaga
Affiliation:
Faculty of Sport and Health Science, Fukuoka University, Fukuoka 814-0184, Japan
*
*Corresponding author: Dr Mayumi Yoshioka, fax +1 418 654 2761, email [email protected]
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Abstract

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Dietary red pepper suppresses energy intake and modifies macronutrient intake. We have investigated whether a stimulus in the mouth and the sensation of spiciness are necessary for red pepper-induced changes in energy and macronutrient intake in human volunteers. In a preliminary test, sixteen Japanese male volunteers tasted samples of a soup with graded doses of red pepper in order to define a moderate and a maximum tolerable (strong) dose of red pepper. On the day of the experiment, a standardised breakfast was given to the volunteers. At lunchtime, the subjects ingested one of four experimental soups containing either a placebo, a moderate or a strong dose of red pepper plus placebo capsules, or a placebo soup plus capsules delivering a strong dose of red pepper. The rest of the meal was given ad libitum to all subjects. The amount of food, protein and carbohydrate ingested was similar for all conditions. Energy and fat intake were similar after the ingestion of the moderate soup compared with placebo. However, the strong soup significantly lowered fat intake compared with placebo (P=0·043), and ingestion of strong capsules also tended to suppress it (P=0·080). Moreover, energy intake after strong soup and capsules tended to be lower than placebo (P=0·089 and 0·076, respectively). The present results indicate that the maximum tolerable dose is necessary to have a suppressive effect of red pepper on fat intake. The main site of the action of red pepper is not in the mouth.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2004

References

Arai, Y, Saul, P, Albrecht, P, Hartley, LH, Lilly, LS, Cohen, RJ & Colucci, WS (1989) Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol 256, H132H141.Google ScholarPubMed
Bennett, C, Reed, GW, Peters, JC, Abumrad, NN, Sun, M & Hill, JO (1992) Short-term effects of dietary-fat ingestion on energy expenditure and nutrient balance. Am J Clin Nutr 55, 10711077.CrossRefGoogle ScholarPubMed
Craft, RM & Porreca, F (1992) Treatment parameters of desensitization to capsaicin. Life Sci 51, 17671775.CrossRefGoogle ScholarPubMed
Diamond, P, Brondel, L & LeBlanc, J (1985) Palatability and postprandial thermogenesis in dogs. Am J Physiol 248, E75E79.Google ScholarPubMed
Doucet, E & Tremblay, A (1997) Food intake, energy balance and body weight control. Eur J Clin Nutr 51, 846855.CrossRefGoogle ScholarPubMed
Dulloo, AG (1998) Spicing fat for combustion. Br J Nutr 80, 493494.CrossRefGoogle ScholarPubMed
Flatt, JP, Ravussin, E, Acheson, KJ & Jéquier, E (1985) Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. J Clin Invest 76, 10191024.CrossRefGoogle ScholarPubMed
Himaya, A & Louis-Sylvestre, J (1998) The effect of soup on satiation. Appetite 30, 199210.CrossRefGoogle ScholarPubMed
Hirayanagi, K, Iwasaki, K, Sasaki, T, Kinugasa, H, Miyamoto, A & Yajima, K (1999) Sensitivity analyses of heart rate variability variables by an incremental, passive head-up tilt. Uchu Koku Kankyo Igaku 36, 6774.Google ScholarPubMed
Iwai, K & Watanabe, A (2000) Red Peppers: Science of Pungency. Tokyo: Saiwai Syobo.Google Scholar
Kendall, A, Levitsky, DA, Strupp, BJ & Lissner, L (1991) Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans. Am J Clin Nutr 53, 11241129.CrossRefGoogle ScholarPubMed
Kissileff, HR (1985) Effects of physical state (liquid-solid) of foods on food intake: procedural and substantive contributions. Am J Clin Nutr 42, 956965.CrossRefGoogle ScholarPubMed
Kobata, K, Sutoh, K, Todo, T, Yazawa, S, Iwai, K & Watanabe, T (1999) Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, capsicum annuum. J Nat Prod 62, 335336.CrossRefGoogle ScholarPubMed
Lim, K, Yoshioka, M, Kikuzato, S, Kiyonaga, A, Tanaka, H, Shindo, M & Suzuki, M (1997) Dietary red pepper ingestion increased carbohydrate oxidation at rest and during exercise in runners. Med Sci Sports Exerc 29, 355361.CrossRefGoogle ScholarPubMed
Lissner, L, Levitsky, DA, Strupp, BJ, Kalkwarf, HJ & Roe, DA (1987) Dietary fat and the regulation of energy intake in human subjects. Am J Clin Nutr 46, 886892.CrossRefGoogle ScholarPubMed
Matsumoto, T, Miyawaki, C, Ue, H, Yuasa, T, Miyatsuji, A & Moritani, T (2000) Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. J Nutr Sci Vitaminol (Tokyo) 46, 309315.CrossRefGoogle ScholarPubMed
Ohnuki, K, Niwa, S, Maeda, S, Inoue, N, Yazawa, S & Fushiki, T (2001 a) CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 65, 20332036.CrossRefGoogle Scholar
Ohnuki, K, Haramizu, S, Oki, K, Watanabe, T, Yazawa, S & Fushiki, T (2001 b) Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 65, 27352740.CrossRefGoogle ScholarPubMed
Ohnuki, K, Haramizu, S, Watanabe, T, Yazawa, S & Fushiki, T (2001 c) CH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate. J Nutr Sci Vitaminol (Tokyo) 47, 295298.CrossRefGoogle Scholar
Paolisso, G, Manzella, D & Ferrara, N (1997) Glucose ingestion affects cardiac ANS in healthy subjects with different amounts of body fat. Am J Physiol 273, E471E478.Google ScholarPubMed
Pomeranz, B, Macaulay, RJ, Caudill, MA, Kutz, I, Adam, D, Gordon, D, Kilborn, KM, Barger, AC, Shannon, DC, Cohen, RJ & Benson, H (1985) Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 248, H151H153.Google ScholarPubMed
Rothwell, NJ & Stock, MJ (1978) A paradox in the control of energy intake in the rat. Nature 273, 146147.CrossRefGoogle ScholarPubMed
Schutz, Y, Flatt, JP & Jéquier, E (1989) Failure of dietary fat intake to promote fat oxidation: a factor favoring the development of obesity. Am J Clin Nutr 50, 307314.CrossRefGoogle ScholarPubMed
Taubes, G (1998) As obesity rates rise, experts struggle to explain why. Science 280, 13671368.CrossRefGoogle ScholarPubMed
Thomas, CD, Peters, JC, Reed, GW, Abumrad, NN, Sun, M & Hill, JO (1992) Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am J Clin Nutr 55, 934942.CrossRefGoogle ScholarPubMed
Warwick, ZS & Schiffman, SS (1992) Role of dietary fat in calorie intake and weight gain. Neurosci Biobehav Rev 16, 585596.CrossRefGoogle ScholarPubMed
Watanabe, A, Kawada, T, Kurosawa, M, Sato, A & Iwai, K (1991) Thermogenic action of capsaicin and its analogs. In Obesity: Dietary Factors and Control, pp. 6777 [Suzuki, M, editor]. Tokyo and Basel: Japan Scientific Societies Press and S Karger AG.Google Scholar
Wickelgren, I (1998) Obesity: how big a problem? Science 280, 13641367.CrossRefGoogle ScholarPubMed
Yoshioka, M, Doucet, E, Drapeau, V, Dionne, I & Tremblay, A (2001) Combined effects of red pepper and caffeine consumption on 24-h energy balance in subjects given free access to foods. Br J Nutr 85, 203211.CrossRefGoogle ScholarPubMed
Yoshioka, M, Lim, K, Kikuzato, S, Kiyonaga, A, Tanaka, H, Shindo, M & Suzuki, M (1995) Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo) 41, 647656.CrossRefGoogle ScholarPubMed
Yoshioka, M, St-Pierre, S, Drapeau, V, Dionne, I, Doucet, E, Suzuki, M & Tremblay, A (1999) Effect of red pepper on appetite and energy intake. Br J Nutr 82, 115123.CrossRefGoogle ScholarPubMed
Yoshioka, M, St-Pierre, S, Suzuki, M & Tremblay, A (1998) Effect of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 80, 503510.CrossRefGoogle ScholarPubMed
Ziegler, D, Piolot, R, Strassburger, K, Lambeck, H & Dannehl, K (1999) Normal ranges and reproducibility of statistical, geometric, frequency domain, and non-linear measures of 24-hour heart rate variability. Horm Metab Res 31, 672679.CrossRefGoogle ScholarPubMed