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Maternal intake of dairy products is inversely associated with birth weight in women with gestational diabetes mellitus: a prospective cohort study
Published online by Cambridge University Press: 19 February 2025
Abstract
This study aimed to investigate the intake of dairy products during pregnancy in women with gestational diabetes mellitus (GDM) and its impacts on neonatal birth weight and pregnancy outcomes. A total of 386 women with GDM during the second trimester pregnancy participated in this prospective cohort study. We evaluated dairy products intake through the FFQ. Pregnancy outcomes were obtained from the delivery data. Participants were divided into insufficient and sufficient intake of milk and dairy products groups (< 300 g/d and ≥ 300 g/d, respectively). The average intake of dairy products during the second trimester pregnancy in women with GDM was 317·8 ± 179·5 g/d, and the total energy intake was 1635·4 ± 708·7 kcal/d. However, 76·68 % of them did not meet the recommended total energy intake of women with GDM. After adjusting for confounding factors, women with GDM who consumed ≥ 300 g/d of dairy products had an average reduction in birth weight of 93·1 g compared with women who consumed < 300 g/d of dairy products (95 % CI −171·343, −14·927). Women with GDM in sufficient intake group was also associated with lower risk of macrosomia (95 % CI 0·043, 0·695) and caesarean section (95 % CI 0·387, 0·933) and not related to low birth weight infant (95 % CI 0·617, 14·502) and preterm birth (95 % CI 0·186, 1·510) when compared with participants in insufficient intake group. Under the premise of insufficient total energy intake, the intake of dairy products during the second trimester pregnancy in women with GDM might be related to the decrease of neonatal birth weight.
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- Research Article
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- © The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society
Footnotes
Cuiling Xie and QingXiang Zheng contributed equally to this work.
References
Buchanan, TA, Xiang, AH & Page, KA (2012) Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8, 639–649.Google Scholar
Alejandro, EU, Mamerto, TP, Chung, G, et al. (2020) Gestational diabetes mellitus: a harbinger of the vicious cycle of diabetes. Int J Mol Sci 21, 5003.Google Scholar
Billionnet, C, Mitanchez, D, Weill, A, et al. (2017) Gestational diabetes and adverse perinatal outcomes from 716 152 births in France in 2012. Diabetologia 60, 636–644.Google Scholar
Choudhury, AA & Devi Rajeswari, V (2021) Gestational diabetes mellitus - a metabolic and reproductive disorder. Biomed Pharmacother 143, 112183.Google Scholar
Kramer, CK, Campbell, S & Retnakaran, R (2019) Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis. Diabetologia 62, 905–914.Google Scholar
Vounzoulaki, E, Khunti, K, Abner, SC, et al. (2020) Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ 369, m1361.Google Scholar
Hillier, TA, Pedula, KL, Schmidt, MM, et al. (2007) Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia. Diabetes Care 30, 2287–2292.Google Scholar
Lawlor, DA, Lichtenstein, P & Långström, N (2011) Association of maternal diabetes mellitus in pregnancy with offspring adiposity into early adulthood: sibling study in a prospective cohort of 280 866 men from 248 293 families. Circulation 123, 258–265.Google Scholar
Yu, ZB, Han, SP, Zhu, GZ, et al. (2011) Birth weight and subsequent risk of obesity: a systematic review and meta-analysis. Obes Rev 12, 525–542.Google Scholar
Mosing, MA, Lundholm, C, Cnattingius, S, et al. (2018) Associations between birth characteristics and age-related cognitive impairment and dementia: a registry-based cohort study. PLoS Med 15, e1002609.Google Scholar
Mathewson, KJ, Chow, CH, Dobson, KG, et al. (2017) Mental health of extremely low birth weight survivors: a systematic review and meta-analysis. Psychol Bull 143, 347–383.Google Scholar
Risnes, KR, Vatten, LJ, Baker, JL, et al. (2011) Birthweight and mortality in adulthood: a systematic review and meta-analysis. Int J Epidemiol 40, 647–661.Google Scholar
Goldstein, RF, Abell, SK, Ranasinha, S, et al. (2017) Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis. JAMA 317, 2207–2225.Google Scholar
Li, N, Liu, E, Guo, J, et al. (2013) Maternal prepregnancy body mass index and gestational weight gain on pregnancy outcomes. PLoS One 8, e82310.Google Scholar
Koletzko, B, Brands, B, Chourdakis, M, et al. (2014) The Power of Programming and the EarlyNutrition project: opportunities for health promotion by nutrition during the first thousand days of life and beyond. Ann Nutr Metab 64, 187–196.Google Scholar
Hernandez, TL, Mande, A & Barbour, LA (2018) Nutrition therapy within and beyond gestational diabetes. Diabetes Res Clin Pract 145, 39–50.Google Scholar
Kgosidialwa, O, Egan, AM, Carmody, L, et al. (2015) Treatment with diet and exercise for women with gestational diabetes mellitus diagnosed using IADPSG criteria. J Clin Endocrinol Metab 100, 4629–4636.Google Scholar
Haug, A, Høstmark, AT & Harstad, OM (2007) Bovine milk in human nutrition--a review. Lipids Health Dis 6, 25.Google Scholar
Walther, B, Guggisberg, D, Badertscher, R, et al. (2022) Comparison of nutritional composition between plant-based drinks and cow’s milk. Front Nutr 9, 988707.Google Scholar
Achón, M, Úbeda, N, García-González, Á, et al. (2019) Effects of milk and dairy product consumption on pregnancy and lactation outcomes: a systematic review. Adv Nutr 10, S74–S87.Google Scholar
Godfrey, K, Robinson, S, Barker, DJ, et al. (1996) Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ 312, 410–414.Google Scholar
Heppe, DH, van Dam, RM, Willemsen, SP, et al. (2011) Maternal milk consumption, fetal growth, and the risks of neonatal complications: the Generation R Study. Am J Clin Nutr 94, 501–509.Google Scholar
Hjertholm, KG, Iversen, PO, Holmboe-Ottesen, G, et al. (2018) Maternal dietary intake during pregnancy and its association to birth size in rural Malawi: a cross-sectional study. Matern Child Nutr 14, e12433.Google Scholar
Hrolfsdottir, L, Rytter, D, Hammer Bech, B, et al. (2013) Maternal milk consumption, birth size and adult height of offspring: a prospective cohort study with 20 years of follow-up. Eur J Clin Nutr 67, 1036–1041.Google Scholar
Xue, F, Willett, WC, Rosner, BA, et al. (2008) Parental characteristics as predictors of birthweight. Hum Reprod 23, 168–177.Google Scholar
Mannion, CA, Gray-Donald, K & Koski, KG (2006) Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ 174, 1273–1277.Google Scholar
Yang, W, Han, N, Jiao, M, et al. (2022) Maternal diet quality during pregnancy and its influence on low birth weight and small for gestational age: a birth cohort in Beijing, China. Br J Nutr 1–10.Google Scholar
Olsen, SF, Halldorsson, TI, Willett, WC, et al. (2007) Milk consumption during pregnancy is associated with increased infant size at birth: prospective cohort study. Am J Clin Nutr 86, 1104–1110.Google Scholar
Sartorelli, DS, Carvalho, MR, da Silva Santos, I, et al. (2021) Dietary total antioxidant capacity during pregnancy and birth outcomes. Eur J Nutr 60, 357–367.Google Scholar
Ludvigsson, JF & Ludvigsson, J (2004) Milk consumption during pregnancy and infant birthweight. Acta Paediatr 93, 1474–1478.Google Scholar
Miyake, Y, Tanaka, K, Okubo, H, et al. (2016) Milk intake during pregnancy is inversely associated with the risk of postpartum depressive symptoms in Japan: the Kyushu Okinawa Maternal and Child Health Study. Nutr Res 36, 907–913.Google Scholar
American Diabetes Association Professional Practice Committee (2022) 2. Classification and Diagnosis of Diabetes: standards of Medical Care in Diabetes-2022. Diabetes Care 45, S17–S38.Google Scholar
Chen, XQ, Zheng, Q, Liao, YP, et al. (2023) Association between plant-based or animal-based dietary pattern and plasma glucose during oral glucose tolerance test among Chinese women with gestational diabetes mellitus: a prospective cohort study. BMJ Open 13, e075484.Google Scholar
Zhang, H, Qiu, X, Zhong, C, et al. (2015) Reproducibility and relative validity of a semi-quantitative food frequency questionnaire for Chinese pregnant women. Nutr J 14, 56.Google Scholar
Yang, YX (2019) China Food Composition Tables Standard Edition (Book 2). Beijing: Peking University Medical Press.Google Scholar
Blencowe, H, Krasevec, J, de Onis, M, et al. (2019) National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health 7, e849–e860.Google Scholar
Willett, WC, Howe, GR & Kushi, LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65, 1220S–1228S; discussion 1229S–1231S.Google Scholar
Chinese Nutrition Society (2022) Dietary Guidelines for Chinese Residents: 2022. Beijing: People’s Medical Publishing House.Google Scholar
Cucó, G, Arija, V, Iranzo, R, et al. (2006) Association of maternal protein intake before conception and throughout pregnancy with birth weight. Acta Obstet Gynecol Scand 85, 413–421.Google Scholar
Lowensohn, RI, Stadler, DD & Naze, C (2016) Current concepts of maternal nutrition. Obstet Gynecol Surv 71, 413–426.Google Scholar
Mousa, A, Naqash, A & Lim, S (2019) Macronutrient and micronutrient intake during pregnancy: an overview of recent evidence. Nutrients 11, 443.Google Scholar
Eshak, ES, Okada, C, Baba, S, et al. (2020) Maternal total energy, macronutrient and vitamin intakes during pregnancy associated with the offspring’s birth size in the Japan Environment and Children’s Study. Br J Nutr 124, 558–566.Google Scholar
Khoushabi, F & Saraswathi, G (2010) Impact of nutritional status on birth weight of neonates in Zahedan City, Iran. Nutr Res Pract 4, 339–344.Google Scholar
Pavlikova, J, Ambroz, A, Honkova, K, et al. (2022) Maternal diet quality and the health status of newborns. Foods 11, 3893.Google Scholar
Reyes-López, MA, González-Leyva, CP, Rodríguez-Cano, AM, et al. (2021) Diet quality is associated with a high newborn size and reduction in the risk of low birth weight and small for gestational age in a group of Mexican pregnant women: an observational study. Nutrients 13, 1853.Google Scholar
Chinese Nutrition Society (2016) Chinese Dietary Guideline. Beijing: People’s Medical Publishing House.Google Scholar
Morisaki, N, Nagata, C, Yasuo, S, et al. (2018) Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction: the Japan Environment and Children’s Study. Br J Nutr 120, 1432–1440.Google Scholar
Sloan, NL, Lederman, SA, Leighton, J, et al. (2001) The effect of prenatal dietary protein intake on birth weight. Nutr Res 21, 129–139.Google Scholar
Weigle, DS, Breen, PA, Matthys, CC, et al. (2005) A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 82, 41–48.Google Scholar
Astrup, A (2005) The satiating power of protein--a key to obesity prevention? Am J Clin Nutr 82, 1–2.Google Scholar
Dove, ER, Hodgson, JM, Puddey, IB, et al. (2009) Skim milk compared with a fruit drink acutely reduces appetite and energy intake in overweight men and women. Am J Clin Nutr 90, 70–75.Google Scholar
Dhillon, J, Craig, BA, Leidy, HJ, et al. (2016) The effects of increased protein intake on fullness: a meta-analysis and its limitations. J Acad Nutr Diet 116, 968–983.Google Scholar
Luhovyy, BL, Akhavan, T & Anderson, GH (2007) Whey proteins in the regulation of food intake and satiety. J Am Coll Nutr 26, 704s–712s.Google Scholar
Boirie, Y, Dangin, M, Gachon, P, et al. (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A 94, 14930–14935.Google Scholar
Bendtsen, LQ, Lorenzen, JK, Bendsen, NT, et al. (2013) Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials. Adv Nutr 4, 418–438.Google Scholar
Chungchunlam, SM, Moughan, PJ, Henare, SJ, et al. (2012) Effect of time of consumption of preloads on measures of satiety in healthy normal weight women. Appetite 59, 281–288.Google Scholar
Chungchunlam, SM, Henare, SJ, Ganesh, S, et al. (2015) Dietary whey protein influences plasma satiety-related hormones and plasma amino acids in normal-weight adult women. Eur J Clin Nutr 69, 179–186.Google Scholar
Jakubowicz, D & Froy, O (2013) Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes. J Nutr Biochem 24, 1–5.Google Scholar
Moore, VM, Davies, MJ, Willson, KJ, et al. (2004) Dietary composition of pregnant women is related to size of the baby at birth. J Nutr 134, 1820–1826.Google Scholar
Pathirathna, ML, Sekijima, K, Sadakata, M, et al. (2017) Impact of second trimester maternal dietary intake on gestational weight gain and neonatal birth weight. Nutrients 9, 627.Google Scholar
Sharma, SS, Greenwood, DC, Simpson, NAB, et al. (2018) Is dietary macronutrient composition during pregnancy associated with offspring birth weight? An observational study. Br J Nutr 119, 330–339.Google Scholar