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Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status

Published online by Cambridge University Press:  09 March 2007

Monique D. M. Al ,
Adriana C. Van Houwelingen ,
Arnold D.M. Kester ,
Tom H.M. Hasaart ,
AndrÉ E. P. De Jong  and
Gerard Hornstra
Monique D. M. Al
Affiliation:
Department of Human Biology, University of Limburg, Maastricht, The Netherlands
Adriana C. Van Houwelingen
Affiliation:
Department of Human Biology, University of Limburg, Maastricht, The Netherlands
Arnold D.M. Kester
Affiliation:
Department of Methodology and Statistics, University of Limburg, Maastricht, The Netherlands
Tom H.M. Hasaart
Affiliation:
Department of Obstetrics and Gynecology, University of Limburg, Maastricht, The Netherlands
AndrÉ E. P. De Jong
Affiliation:
Analytical Biochemical Laboratory, Assen, The Netherlands
Gerard Hornstra
Affiliation:
Department of Human Biology, University of Limburg, Maastricht, The Netherlands
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Abstract

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Although essential fatty acids (EFA) and their longer chain, more unsaturated derivatives play a major role during pregnancy, hardly any information is available with respect to the course of the maternal EFA status during an uncomplicated pregnancy and its relationship to the neonatal EFA status. Therefore, a longitudinal study was started in which 110 pregnant women gave repeated blood samples from the 10th week of gestation until delivery. After birth a blood sample from the umbilical vein and a maternal venous blood sample were collected as well, and 6 months after delivery a final blood sample from the mother was taken. The absolute (mg/l) and relative (% total fatty acids) amounts of the fatty acids in plasma phospholipids were determined. The total amounts of fatty acids increased significantly during pregnancy. This pattern was similar for the individual fatty acids and fatty acid families. The relative amount of linoleic acid (18:2n−6) did not change during pregnancy, whereas the relative amount of arachidonic acid (20:4n−6) decreased. Despite maternal mobilization of docosahexaenoic acid (22:6n−3, DHA), suggested by a temporary increase in the DHA status until 18 weeks gestation, the DHA status steadily declined thereafter. This pattern was associated with a progressive increase in the DHA deficiency index in maternal blood throughout pregnancy and resulted in a sub-optimal neonatal DHA status. The overall maternal EFA status also declined steadily during pregnancy. Therefore, the question arises whether the mother, under the prevailing dietary conditions, is able to meet the high fetal requirement for EFA.

Keywords

Essential fatty acidsDocosahexaenoic acidPregnancyHuman
Type
EFA status in pregnancy
Information
British Journal of Nutrition , Volume 74 , Issue 1 , July 1995 , pp. 55 - 68
Copyright
Copyright © The Nutrition Society 1995

References

Al, M. D. M. (1994) Essential fatty acids, pregnancy, and pregnancy outcome: relationship between mother and child. PhD Thesis, University of Limburg, The Netherlands.Google Scholar
Al, M. D. M., Hornstra, G., van der Schouw, Y. T., Bulstra-Ramakers, M. T. E. W. & Huisjes, H. J. (1990) Biochemical essential fatty acid status of mothers and their neonates after normal pregnancy. Early Human Development 24, 239–248.CrossRefGoogle ScholarPubMed
Andersen, H. J., Andersen, L. F. & Fuchs, A. R. (1989) Diet, pre-eclampsia and intra-uterine growth retardation. Lancet i, 1146.CrossRefGoogle Scholar
Baker, P. & Broughton-Ppkin, F. (1991) Fish-oil and pre-eclampsia (letter). British Journal of Obstetrics and Gynaecology 98, 499–500.CrossRefGoogle Scholar
Chambaz, J., Ravel, D., Manier, M.-C., Pepin, D., Mulliez, N. & Bereziat, G. (1985) Essential fatty acids interconversion in the human fetal liver. Biology of the Neonate 47, 136–140.CrossRefGoogle ScholarPubMed
Clandinin, M. T., Chappell, J. E., Leong, S., Heim, T., Swyer, P. R. & Chance, G. W. (1980) Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Human Development 4, 121–129.CrossRefGoogle ScholarPubMed
Coleman, R. A. (1989) The role of the placenta in lipid metabolism and transport. Seminars in Perinatology 13, 180–191.Google ScholarPubMed
de Jong, A. E. P., van den Berg, T. S., Nijmeijer-Couprie, A, Goedhart, J. P. & Oosting, E. (1993) Long-term aspects of phospholipidic analysis of fatty acid methylesters by use of nonpolar capillary gas chromatography. American Journal of Clinical Nutrition 57, Suppl., 813S.CrossRefGoogle Scholar
Desoye, G., Schweditsch, M. O., Pfeiffer, K. P., Zecher, R. & Kostner, G. M. (1987) Correlation of hormones with lipid and lipoprotein levels during normal pregnancy and post-partum. Journal of Clinical Endocrinology and Metabolism 64, 704–712.CrossRefGoogle Scholar
Dixon, W. J. (1990) BMDP Statistical Software Manual, Vol. 2. Berkeley: University of California Press.Google Scholar
Dobbing, J. (1972) Vulnerable periods of brain development. In Lipids, Malnutrition and the Developing Brain, pp. 9–29 [Elliott, K. and Knight, J., editors]. Amsterdam: Elsevier.Google Scholar
Dyerberg, J. & Bang, H. O. (1985) Pre-eclampsia and prostaglandins (letter). Lancet i, 1267.CrossRefGoogle Scholar
Fliesler, S. J. & Anderson, R. E. (1983) Chemistry and metabolism of lipids in the vertebrate retina. Progress in Lipid Research 22, 79–131.CrossRefGoogle ScholarPubMed
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Holman, R. T. (1960) The ratio of trienoic:tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. Journal of Nutrition 70, 405–410.CrossRefGoogle ScholarPubMed
Holman, R. T. (1986) Control of poly-unsaturated fatty acids in tissue lipids. Journal of the American College of Nutrition 5, 183–211.CrossRefGoogle Scholar
Hornstra, G. (1992) Essential fatty acids, pregnancy and pregnancy complications: a round table discussion. In Essential Fatty Acids and Eicosanoids. Invited Papers from the Third International Congress, pp. 177–182 [Sinclair, A. and Gibson, R., editors]. Champaign, IL: American Oil Chemists Society.Google Scholar
Hornstra, G., Al, M. D. M., Gerrard, J. M. & Simonis, M. M. G. (1992) Essential fatty acid status of neonates born to Inuit mothers: comparison with Caucasian neonates and effect of diet. Prostaglandins, Leukotrienes and Essential Fatty Acids 45, 125–130.CrossRefGoogle ScholarPubMed
Hoving, E. B., Jansen, G., Volmer, M., Van Doormaal, J. J. & Muskiet, F. A. J. (1988) Profiling of plasma cholesterol ester and triglyceride fatty acids as their methyl esters by capillary gas chromatography, preceded by a rapid aminopropyl-silica column chromatographic separation of lipid classes. Journal of Chromatography 434, 395–409.CrossRefGoogle ScholarPubMed
Innis, S. M. (1991) Essential fatty acids in growth and development. Progress in Lipid Research 30, 39–103.CrossRefGoogle ScholarPubMed
Jennrich, R. I. & Schluchter, M. D. (1986) Unbalanced repeated-measures models with structured covariance matrices. Biometries 42, 805–820.CrossRefGoogle ScholarPubMed
Kaluzny, M. A., Duncan, L. A., Merritt, M. V. & Epps, D. E. (1985) Rapid separation of lipid classes in high yield and purity using bonded phase columns. Journal of Lipid Research 26, 135–140.CrossRefGoogle ScholarPubMed
Kloosterman, G. J. (1970) On intrauterine growth. International Journal of Gynaecology and Obstetrics 8, 895–912.CrossRefGoogle Scholar
Kuhn, D. C. & Crawford, M. (1986) Placental essential fatty acid transport and prostaglandin synthesis. Progress in Lipid Research 25, 345–353.CrossRefGoogle ScholarPubMed
Leaf, A. A., Leighfield, M. J., Costeloe, K. L. & Crawford, M. A. (1992) Long chain polyunsaturated fatty acids and fetal growth. Early Human Development 30, 183–191.CrossRefGoogle ScholarPubMed
Makrides, M., Simmer, K., Goggin, M. & Gibson, R. A. (1993) Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. Pediatric Research 34, 425–427.Google Scholar
Martinez, M. (1989) Dietary poly-unsaturated fatty acids in relation to neural development in humans. Progress in Lipid Research 28, 123–133.Google Scholar
Martinez, M. (1991) Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and Pseudo-Zellweger's syndromes. World Review of Nutrition and Dietetics 66, 87–102.CrossRefGoogle ScholarPubMed
Martinez, M., Ballabriga, A. & Gil-Gibernau, J. J. (1988) Lipids of the developing human retina. I. Total fatty acids, plasmalogens, and fatty acid composition of ethanolamine and choline phosphoglycerides. Journal of Neuroscience Research 20, 484–490.CrossRefGoogle ScholarPubMed
Morrisson, W. R. & Smith, L. M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. Journal of Lipid Research 5, 600–608.CrossRefGoogle Scholar
Neuringer, M., Connor, W. E., Lin, D. S., Barstad, L. & Luck, S. (1986) Biochemical and functional effects of prenatal and postnatal ω-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proceedings of the National Academy of Sciences USA 83, 4021–4025.CrossRefGoogle ScholarPubMed
Olsen, S. F., Dalby-SØrensen, J. D., Secher, N. J., Hedegaard, M., Hendriksen, T. B., Hansen, H. S. & Grant, A. (1992) Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 339, 1003–1007.CrossRefGoogle ScholarPubMed
Popeski, D., Ebbeling, L. R., Brown, P. B., Hornstra, G. & Gerrard, J. M. (1991) Blood pressure during pregnancy in Canadian Inuit: community differences related to diet. Canadian Medical Association Journal 145, 44–54.Google ScholarPubMed
Sastry, P. S. (1985) Lipids of nervous tissue: composition and metabolism. Progress in Lipid Research 24, 69–176.CrossRefGoogle Scholar
Secher, N. J. & Olsen, S. F. (1990) Fish-oil and pre-eclampsia (commentaries). British Journal of Obstetrics and Gynaecology 97, 1077–1079.CrossRefGoogle Scholar
Subbiah, M. T. R. (1991) Newly recognized lipid carrier proteins in fetal life. Proceedings of the Society for Experimental Biology and Medicine 198, 459–499.Google ScholarPubMed
Svennerholm, L. (1968) Distribution and fatty acid composition of phosphoglycerides in normal human brain. Journal of Lipid Research 9, 570–579.CrossRefGoogle ScholarPubMed
Uauy, R., Birch, E., Birch, D. & Peirano, P. (1992) Visual and brain function measurements in studies of n−3 fatty acid requirements of infants. Journal of Pediatrics 120, S168–S180.CrossRefGoogle ScholarPubMed
van der Schouw, Y. T., Al, M. D. M., Hornstra, G., Bulstra-Ramakers, M. T. E. W. & Huisjes, H. J. (1991) Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. Prostaglandins, Leukotrienes and Essential Fatty Acids 44, 247–252.CrossRefGoogle ScholarPubMed
van Houwelingen, A. C., Puls, J. & Hornstra, G. (1992) Essential fatty acid status during early human development. Early Human Development 31, 97–111.CrossRefGoogle ScholarPubMed
Vilbergsson, G., Samsioe, G., Wennergren, M. & Karlsson, K. (1991) Essential fatty acids in pregnancies complicated by intrauterine growth retardation. International Journal of Gynaecology and Obstetrics 36, 277–286.CrossRefGoogle ScholarPubMed
Voss, A., Reinhart, M. & Sprecher, H. (1992) Differences in the interconversion between 20- and 22-carbon (n-3) and (n-6) polyunsaturated fatty acids in rat liver. Biochimica et Biophysica Acta 1127, 33–40.CrossRefGoogle ScholarPubMed
Wang, Y., Kay, H. H. & Killam, A. P. (1991) Decreased levels of polyunsaturated fatty acids in pre-eclampsia. American Journal of Obstetrics and Gynecology 164, 812–818.CrossRefGoogle Scholar